Abstract Bio-based natural insect repellent is an innovative green solution in the present scenario. They are already practiced traditionally and are quite effective, safe as compared to synthetic repellents. However, there are many natural repellents which should be used below a critical concentration above which they may also act as toxic solution. The knowledge of natural insect repellents can be obtained by two ways, that is, bioprospecting and ethano-botanical studies. Bioprospecting is the most popular way to find potential natural repellents. Apart from safe limitation for their usages, other problem associated with natural repellent is their durability as far as textile application point of view. To address the issue, various approaches have been demonstrated. The performance can be improved by microencapsulation technique and the use of nanotechnology, which slow down the release rate of active ingredients of the extracts to obtain insect-repellent efficacy for relatively longer duration. This chapter presents a summery on types of plant-based repellents, their mechanism of action against insects, application on textiles, their integration to textile substrates, safety concerns, evaluation methods, and application fields related to textiles.