Immunoglobulin E oligomers identified in blood components activate mast cells: relevance to anaphylactic transfusion reaction

BACKGROUND: In most cases of anaphylactic transfusion reaction, the mechanisms underlying its development are unclear. We found a donor whose transfused blood components were implicated in two cases of anaphylactic transfusion reaction, and we found that the donor plasma showed mast cell degranulation activity.

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