An overview of experimental investigations into the use of the voice pitch mode (F0 m) as a distance tool for the monitoring of emotional stress reactions is given. Seven experiments are summarized describing the relations between voice reaction and psychological and physical load in laboratory and field applications. The reactivity of F0 m to mental load depends on psychological personality traits. F0 m is less related to physical load. The evaluation of F0 m as voice stress indicator requires an individual calibration. This calibration has to include the assessment of the individual Autonomic Outlet Type (AOT) because the physiological relevance of voice reactions depends on the individual AOT. The calibration is based on statistical reference data which have to be improved in the future. The calibration has to be done under comparable environmental circumstances. A 3-yr application of the method on board Mir station documents the applicability of the procedure.