Practical and Scalable Manufacturing Process for a Novel Dual-Acting Serotonergic Antidepressant Vilazodone

Vilazodone combines the effects of a selective serotonin reuptake inhibitor with the 5-HT1A receptor partial agonist activity. Here, we report the development of a viable and scalable process for m...

[1]  S. Anzali,et al.  Synthesis and Structure−Activity Relationship in a Class of Indolebutylpiperazines as Dual 5-HT1A Receptor Agonists and Serotonin Reuptake Inhibitors , 2004 .

[2]  Jian Zhang,et al.  Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment. , 2018, Bioorganic & medicinal chemistry.

[3]  Prasenjit Das,et al.  Amidation and N-Boc Deprotection Process Improvement for the Preparation of 5-(1-Piperazinyl)benzofuran-2-carboxamide, a Key Intermediate of Vilazodone , 2014 .

[4]  Bang-Chi Chen,et al.  An Efficient Fischer Indole Synthesis of Avitriptan, a Potent 5-HT1D Receptor Agonist , 1997 .

[5]  Bin Hu,et al.  Scale-Up Synthesis of Antidepressant Drug Vilazodone , 2012 .

[6]  C. Obinger,et al.  Structure-based design, synthesis, and pharmacological evaluation of 3-(aminoalkyl)-5-fluoroindoles as myeloperoxidase inhibitors. , 2010, Journal of medicinal chemistry.

[7]  C. Reed,et al.  A 1-Year, Open-Label Study Assessing the Safety and Tolerability of Vilazodone in Patients With Major Depressive Disorder , 2011, Journal of clinical psychopharmacology.

[8]  Sue-Jane Wang,et al.  Vilazodone: clinical basis for the US Food and Drug Administration's approval of a new antidepressant. , 2011, The Journal of clinical psychiatry.

[9]  N. Anitha,et al.  Alternative Approach to Synthesis of 3-(4-chloro butyl)-1H-indole-5-carbonitrile: A Key Intermediate of Vilazodone Hydrochloride, an Antidepressant Drug , 2014 .