EEG under anesthesia - Feature extraction with TESPAR

We investigated the problem of automatic depth of anesthesia (DOA) estimation from electroencephalogram (EEG) recordings. We employed Time Encoded Signal Processing And Recognition (TESPAR), a time-domain signal processing technique, in combination with multi-layer perceptrons to identify DOA levels. The presented system learns to discriminate between five DOA classes assessed by human experts whose judgements were based on EEG mid-latency auditory evoked potentials (MLAEPs) and clinical observations. We found that our system closely mimicked the behavior of the human expert, thus proving the utility of the method. Further analyses on the features extracted by our technique indicated that information related to DOA is mostly distributed across frequency bands and that the presence of high frequencies (> 80 Hz), which reflect mostly muscle activity, is beneficial for DOA detection.

[1]  J. Jakobsson,et al.  Entropy of EEG during anaesthetic induction: a comparative study with propofol or nitrous oxide as sole agent. , 2004, British journal of anaesthesia.

[2]  F. Weber,et al.  Electroencephalographic Narcotrend Index monitoring during procedural sedation and analgesia in children , 2008, Paediatric anaesthesia.

[3]  Thomas K. Gregory,et al.  An electroencephalographic processing algorithm specifically intended for analysis of cerebral electrical activity , 1986, Journal of clinical monitoring.

[4]  A. Yli-Hankala,et al.  Description of the Entropy™ algorithm as applied in the Datex‐Ohmeda S/5™ Entropy Module , 2004, Acta anaesthesiologica Scandinavica.

[5]  K. W. Cattermole Bipartite communication networks with optimal connectivity , 1972 .

[6]  Joachim Boldt,et al.  Bispectral index in patients with target-controlled or manually-controlled infusion of propofol. , 2002, Anesthesia and analgesia.

[7]  S. Barker,et al.  The Bispectral Index Declines During Neuromuscular Block in Fully Awake Persons , 2003, Anesthesia and analgesia.

[8]  Leo Breiman,et al.  Bagging Predictors , 1996, Machine Learning.

[9]  P Caminal,et al.  Comparison of auditory evoked potentials and the A‐line ARX Index for monitoring the hypnotic level during sevoflurane and propofol induction , 2002, Acta anaesthesiologica Scandinavica.

[10]  N R BURCH,et al.  PERIOD ANALYSIS OF THE ELECTROENCEPHALOGRAM ON A GENERAL‐PURPOSE DIGITAL COMPUTER * , 1964, Annals of the New York Academy of Sciences.

[11]  A. Pérez-Villalba Rhythms of the Brain, G. Buzsáki. Oxford University Press, Madison Avenue, New York (2006), Price: GB £42.00, p. 448, ISBN: 0-19-530106-4 , 2008 .

[12]  J. Sigl,et al.  Anesthesia awareness and the bispectral index. , 2008, The New England journal of medicine.

[13]  Patrick Karasinski,et al.  Monitoring anesthesia using neural networks: A survey , 2002, Journal of Clinical Monitoring and Computing.

[14]  C Thornton,et al.  Evoked responses in anaesthesia. , 1998, British journal of anaesthesia.

[15]  I F Russell,et al.  The Narcotrend 'depth of anaesthesia' monitor cannot reliably detect consciousness during general anaesthesia: an investigation using the isolated forearm technique. , 2006, British journal of anaesthesia.

[16]  Arthur Schultz,et al.  Comparison of Narcotrend Index, Bispectral Index, spectral and entropy parameters during induction of propofol-remifentanil anaesthesia , 2008, Journal of Clinical Monitoring and Computing.

[17]  W. Gosling,et al.  Time-encoded speech , 1978 .

[18]  H. Jasper,et al.  The ten-twenty electrode system of the International Federation. The International Federation of Clinical Neurophysiology. , 1999, Electroencephalography and clinical neurophysiology. Supplement.

[19]  Geoffrey E. Hinton,et al.  Learning representations by back-propagating errors , 1986, Nature.

[20]  Karen B. Domino,et al.  The Incidence of Awareness During Anesthesia: A Multicenter United States Study , 2004, Anesthesia and analgesia.

[21]  Xin Yao,et al.  Diversity creation methods: a survey and categorisation , 2004, Inf. Fusion.

[22]  S. Kreuer,et al.  Narcotrend Monitoring Allows Faster Emergence and a Reduction of Drug Consumption in Propofol–Remifentanil Anesthesia , 2003, Anesthesiology.

[23]  E. Kochs,et al.  Detection of awareness in surgical patients with EEG-based indices--bispectral index and patient state index. , 2003, British journal of anaesthesia.

[24]  Steven W. Smith,et al.  The Scientist and Engineer's Guide to Digital Signal Processing , 1997 .

[25]  Yoji Saito,et al.  Effects of epidural anesthesia with 0.2% and 1% ropivacaine on predicted propofol concentrations and bispectral index values at three clinical end points. , 2006, Journal of clinical anesthesia.

[26]  Susan Pockett,et al.  Anesthesia and the Electrophysiology of Auditory Consciousness , 1999, Consciousness and Cognition.

[27]  J. Drummond,et al.  Monitoring depth of anesthesia: with emphasis on the application of the bispectral index and the middle latency auditory evoked response to the prevention of recall. , 2000, Anesthesiology.

[28]  Kagan Tumer,et al.  Error Correlation and Error Reduction in Ensemble Classifiers , 1996, Connect. Sci..

[29]  P Caminal,et al.  Identification of causal relations between haemodynamic variables, auditory evoked potentials and isoflurane by means of fuzzy logic. , 1999, British journal of anaesthesia.

[30]  I. Rampil A Primer for EEG Signal Processing in Anesthesia , 1998, Anesthesiology.

[31]  Kazuyoshi Hirota,et al.  Special cases: ketamine, nitrous oxide and xenon. , 2006, Best practice & research. Clinical anaesthesiology.

[32]  Enrico Mach,et al.  FOR LOW POWER , 1997 .

[33]  Geoffrey E. Hinton,et al.  Learning representations by back-propagation errors, nature , 1986 .

[34]  Peter Norvig,et al.  Artificial Intelligence: A Modern Approach , 1995 .

[35]  K. Leslie,et al.  For Personal Use. Only Reproduce with Permission from the Lancet , 2022 .

[36]  Fritz F. Klein A Waveform Analyzer Applied to the Human EEG , 1976, IEEE Transactions on Biomedical Engineering.

[37]  A. Schlögl,et al.  Artifact Processing in Computerized Analysis of Sleep EEG – A Review , 1999, Neuropsychobiology.

[38]  E. Facco,et al.  Spectral entropy assessment with auditory evoked potential in neuroanesthesia , 2007, Clinical Neurophysiology.

[39]  D. Chernik,et al.  Validity and Reliability of the Observer's: Assessment of Alertness/Sedation Scale Study with Intravenous Midazolam , 1990, Journal of clinical psychopharmacology.

[40]  R E Anderson,et al.  Use of conventional ECG electrodes for depth of anaesthesia monitoring using the cerebral state index: a clinical study in day surgery. , 2007, British journal of anaesthesia.

[41]  Yoav Freund,et al.  Experiments with a New Boosting Algorithm , 1996, ICML.

[42]  R. A. King,et al.  Shannon, TESPAR and approximation strategies , 1999, Comput. Secur..