Aerobic exercises alleviate symptoms of fatigue related to inflammatory cytokines in obese patients with type 2 diabetes.

BACKGROUND Non-insulin dependent diabetic patients frequently suffer from fatigue symptoms that result from chronic systemic inflammation. Aerobic exercise was proved to modulate systemic inflammation. OBJECTIVE This study was an attempt to measure the impact of aerobic exercises on fatigue symptoms related to systemic inflammation in obese patients with type 2 diabetes. METHODS Eighty obese patients with type 2 diabetes participated in the present study, their age ranged from 40-58 years and their BMI ranged from 31-36 kg/m2 and were assigned to two subgroups; group (A) received aerobic exercise training for 12 weeks and group (B) received no exercise training for 3 months. Measurements of fatigue symptoms and markers of systemic inflammation were assessed before and at the end of the study for all participants in both groups. RESULTS The mean values of inflammatory markers (IL-6 and TNF-α) and Multidimensional Fatigue Inventory (MFI) was significantly decreased in group (A), while changes were not significant in group (B). Moreover, there were significant differences between mean levels of the investigated parameters in group (A) and group (B) at the end of the study. CONCLUSION Treadmill walking exercise training is an effective treatment policy to improve symptoms of fatigue related to inflammatory cytokines in obese patients with type 2 diabetes.

[1]  G. Cunnane,et al.  The Effect of Exercise on Sleep and Fatigue in Rheumatoid Arthritis: A Randomized Controlled Study , 2014, The Journal of Rheumatology.

[2]  K. Chinna,et al.  Preliminary study of an exercise programme for reducing fatigue and improving sleep among long-term haemodialysis patients. , 2014, Singapore medical journal.

[3]  Wen-Li Lin,et al.  The Effect of Yoga Exercise on Improving Depression, Anxiety, and Fatigue in Women With Breast Cancer: A Randomized Controlled Trial , 2014, The journal of nursing research : JNR.

[4]  A. McFadyen,et al.  Short-term effect of aerobic exercise on symptoms in multiple sclerosis and chronic fatigue syndrome: a pilot study. , 2014, International journal of MS care.

[5]  B. Sangelaji,et al.  Effect of Combination Exercise Therapy on Walking Distance, Postural Balance, Fatigue and Quality of Life in Multiple Sclerosis Patients: A Clinical Trial Study , 2014, Iranian Red Crescent medical journal.

[6]  M. Bernardi,et al.  Low-grade systemic inflammation and leptin levels were improved by arm cranking exercise in adults with chronic spinal cord injury. , 2014, Archives of physical medicine and rehabilitation.

[7]  H. Gin,et al.  Fatigue symptoms relate to systemic inflammation in patients with type 2 diabetes , 2012, Brain, Behavior, and Immunity.

[8]  E. Hacker,et al.  Fatigue in Women With Type 2 Diabetes , 2012, The Diabetes educator.

[9]  Elliott M. McMillan,et al.  Exercise is an effective treatment modality for reducing cancer-related fatigue and improving physical capacity in cancer patients and survivors: a meta-analysis. , 2011, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[10]  R. Dantzer,et al.  The associations of adiposity, physical activity and inflammation with fatigue in older adults , 2011, Brain, Behavior, and Immunity.

[11]  H. Gast,et al.  Inhibition of IL-1β Improves Fatigue in Type 2 Diabetes , 2011, Diabetes Care.

[12]  B. Pedersen.  Exercise-induced myokines and their role in chronic diseases , 2011, Brain, Behavior, and Immunity.

[13]  Y. Hung,et al.  Circulating pro-inflammatory cytokines and adiponectin in young men with type 2 diabetes , 2011, Acta Diabetologica.

[14]  Andrew H. Miller,et al.  Immune system to brain signaling: neuropsychopharmacological implications. , 2011, Pharmacology & therapeutics.

[15]  H. Kolb,et al.  Pro- and anti-inflammatory cytokines in latent autoimmune diabetes in adults, type 1 and type 2 diabetes patients: Action LADA 4 , 2011, Diabetologia.

[16]  M. Matoulek,et al.  The effect of very-low-calorie diet on mRNA expression of inflammation-related genes in subcutaneous adipose tissue and peripheral monocytes of obese patients with type 2 diabetes mellitus. , 2011, The Journal of clinical endocrinology and metabolism.

[17]  P. O S I T I O N S T A T E M E N T,et al.  Diagnosis and Classification of Diabetes Mellitus , 2011, Diabetes Care.

[18]  Laurie Quinn,et al.  Fatigue in patients with diabetes: a review. , 2010, Journal of psychosomatic research.

[19]  Sheng-Chia Chung,et al.  The effect of obesity on quality of life in patients with diabetes and coronary artery disease. , 2010, American heart journal.

[20]  E. McAuley,et al.  Reduction in trunk fat predicts cardiovascular exercise training-related reductions in C-reactive protein , 2009, Brain, Behavior, and Immunity.

[21]  Alfonso T. Perez,et al.  Relation of Abdominal Fat Depots to Systemic Markers of Inflammation in Type 2 Diabetes , 2009, Diabetes Care.

[22]  Susan T. Stewart,et al.  The Impact of Symptoms and Impairments on Overall Health in US National Health Data , 2008, Medical care.

[23]  Patrick J. O’Connor,et al.  A Randomized Controlled Trial of the Effect of Aerobic Exercise Training on Feelings of Energy and Fatigue in Sedentary Young Adults with Persistent Fatigue , 2008, Psychotherapy and Psychosomatics.

[24]  K. Makrilakis,et al.  Cytokine Secretion in Long-standing Diabetes Mellitus Type 1 and 2: Associations with Low-grade Systemic Inflammation , 2008, Journal of Clinical Immunology.

[25]  B. Pedersen,et al.  The role of IL-6 in mediating the anti-inflammatory effects of exercise. , 2006, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[26]  P. O’Connor,et al.  Chronic physical activity and feelings of energy and fatigue. , 2005, Medicine and science in sports and exercise.

[27]  K. Stewart.  Role of exercise training on cardiovascular disease in persons who have type 2 diabetes and hypertension. , 2004, Cardiology clinics.

[28]  G. Leese,et al.  Barriers to physical activity in patients with diabetes , 2004, Postgraduate Medical Journal.

[29]  J. Pickup.  Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. , 2004, Diabetes care.

[30]  J. Damås,et al.  Exercise reduces plasma levels of the chemokines MCP-1 and IL-8 in subjects with the metabolic syndrome. , 2004, European heart journal.

[31]  P. Hogan,et al.  Economic Costs of Diabetes in the U.S. in 2002 , 2003, Diabetes care.

[32]  Barbara A. Smith,et al.  Aerobic exercise: effects on parameters related to fatigue, dyspnea, weight and body composition in HIV-infected adults , 2001, AIDS.

[33]  E. Smets,et al.  The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. , 1995, Journal of psychosomatic research.

[34]  Roy J. Shephard,et al.  Guidelines for Graded Exercise Testing and Exercise Prescription , 1981 .

[35]  Chia-Chun Li,et al.  Effects of an aerobic exercise programme on fatigue for patients with breast cancer undergoing radiotherapy. , 2015, Journal of clinical nursing.

[36]  Reed Humphrey,et al.  Resource Manual for Guidelines for Graded Exercise Testing and Prescription: American College of Sports Medicine Lea & Febiger , 1994 .