WEGO: a web tool for plotting GO annotations

Unified, structured vocabularies and classifications freely provided by the Gene Ontology (GO) Consortium are widely accepted in most of the large scale gene annotation projects. Consequently, many tools have been created for use with the GO ontologies. WEGO (Web Gene Ontology Annotation Plot) is a simple but useful tool for visualizing, comparing and plotting GO annotation results. Different from other commercial software for creating chart, WEGO is designed to deal with the directed acyclic graph structure of GO to facilitate histogram creation of GO annotation results. WEGO has been used widely in many important biological research projects, such as the rice genome project and the silkworm genome project. It has become one of the daily tools for downstream gene annotation analysis, especially when performing comparative genomics tasks. WEGO, along with the two other tools, namely External to GO Query and GO Archive Query, are freely available for all users at . There are two available mirror sites at and . Any suggestions are welcome at wego@genomics.org.cn.

[1]  Emily Dimmer,et al.  The Gene Ontology Annotation (GOA) Database: sharing knowledge in Uniprot with Gene Ontology , 2004, Nucleic Acids Res..

[2]  Ravi Sachidanandam,et al.  GObar: A Gene Ontology based analysis and visualization tool for gene sets , 2005, BMC Bioinformatics.

[3]  Andrew Young,et al.  OntologyTraverser: an R package for GO analysis , 2005, Bioinform..

[4]  David Martin,et al.  GOToolBox: functional analysis of gene datasets based on Gene Ontology , 2004, Genome Biology.

[5]  J. Blake,et al.  Creating the Gene Ontology Resource : Design and Implementation The Gene Ontology Consortium 2 , 2001 .

[6]  Hans Lehrach,et al.  Automated Gene Ontology annotation for anonymous sequence data , 2003, Nucleic Acids Res..

[7]  Dawei Li,et al.  The Genomes of Oryza sativa: A History of Duplications , 2005, PLoS biology.

[8]  Günther Zehetner,et al.  OntoBlast function: from sequence similarities directly to potential functional annotations by ontology terms , 2003, Nucleic Acids Res..

[9]  Geoffrey J. Barton,et al.  GOtcha: a new method for prediction of protein function assessed by the annotation of seven genomes , 2004, BMC Bioinformatics.

[10]  Carl J. Schmidt,et al.  GoFigure: Automated Gene OntologyTM annotation , 2003, Bioinform..

[11]  A. Oliphant,et al.  A draft sequence of the rice genome (Oryza sativa L. ssp. japonica). , 2002, Science.

[12]  Hans Lehrach,et al.  GOblet: a platform for Gene Ontology annotation of anonymous sequence data , 2004, Nucleic Acids Res..

[13]  Huanming Yang,et al.  A Draft Sequence of the Rice Genome (Oryza sativa L. ssp. japonica) , 2002, Science.

[14]  Dawei Li,et al.  A Draft Sequence for the Genome of the Domesticated Silkworm ( Bombyx mori ) , 2004 .

[15]  Gene Ontology Consortium The Gene Ontology (GO) database and informatics resource , 2003 .

[16]  Bing Zhang,et al.  GOTree Machine (GOTM): a web-based platform for interpreting sets of interesting genes using Gene Ontology hierarchies , 2004, BMC Bioinformatics.

[17]  David Botstein,et al.  GO: : TermFinder--open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes , 2004, Bioinform..

[18]  D. Barrell,et al.  The Gene Ontology Annotation (GOA) project: implementation of GO in SWISS-PROT, TrEMBL, and InterPro. , 2003, Genome research.

[19]  M. Ashburner,et al.  Gene Ontology: tool for the unification of biology , 2000, Nature Genetics.