Comparative Assay of HCG, HCT and HCS in Molar Pregnancy

Abstract. The authors studied the secretion patterns of three chorionic polypeptide hormones (HCG, HCT and HCS) and the clinical usefulness of the assay of these hormones in patients with hydatidiform mole, by means of systematic serial estimation, in comparison with the secretion patterns in normal pregnancy. The serum levels of HCG and HCT in molar pregnancy were usually higher than in normal pregnancy but HCS levels were below the lower limit of normal pregnancy of the same gestational age. This dissociation between the chorionic glycoprotein hormones (HCG and HCT) and the simple protein hormone (HCS) is thought to be one of the characteristic findings in molar pregnancy. Although the amounts of HCG and HCT did not change 6 hours after the evacuation of hydatidiform mole, the concentration of HCS decreased rapidly and 60 min later it became undetectable. Thus, these polypeptide hormones disappeared in the order HCS, HCT and HCG after the evacuation of mole.

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