Tau in Alzheimer disease and related tauopathies.
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Fei Liu | Khadija Iqbal | I. Grundke‐Iqbal | K. Iqbal | C. Gong | F. Liu | K Iqbal | I Grundke-Iqbal | F Liu | C-X Gong | F. Liu | F. Liu | F. Liu
[1] H. Braak,et al. Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques , 1986, Neuroscience Letters.
[2] F. LaFerla,et al. Reduction of Soluble Aβ and Tau, but Not Soluble Aβ Alone, Ameliorates Cognitive Decline in Transgenic Mice with Plaques and Tangles* , 2006, Journal of Biological Chemistry.
[3] E. Mandelkow,et al. Nonsaturable Binding Indicates Clustering of Tau on the Microtubule Surface in a Paired Helical Filament-like Conformation* , 2000, The Journal of Biological Chemistry.
[4] Bradley T. Hyman,et al. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease , 1992, Neurology.
[5] J. Ávila,et al. Polymerization of τ into Filaments in the Presence of Heparin: The Minimal Sequence Required for τ ‐ τ Interaction , 1996 .
[6] I. Grundke‐Iqbal,et al. Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration , 2007, The European journal of neuroscience.
[7] John Hardy,et al. CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation , 2004 .
[8] E. Mandelkow,et al. Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[9] M. Paula-Barbosa,et al. ALZHEIMER'S DISEASE: PAIRED HELICAL FILAMENTS AND CYTOMEMBRANES , 1987, Neuropathology and applied neurobiology.
[10] R. Takahashi,et al. In vivo evidence of CHIP up‐regulation attenuating tau aggregation , 2005, Journal of neurochemistry.
[11] George Perry,et al. Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation. , 2003, The American journal of pathology.
[12] N. Cairns,et al. Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms , 1992, Neuron.
[13] Bin Li,et al. Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau , 2007, Acta Neuropathologica.
[14] B. Winblad,et al. Neurofibrillary degeneration in Alzheimer's disease: from molecular mechanisms to identification of drug targets , 2008, Current opinion in psychiatry.
[15] H. Wiśniewski,et al. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[16] I. Landrieu,et al. Structural impact of heparin binding to full-length Tau as studied by NMR spectroscopy. , 2006, Biochemistry.
[17] G. Jicha,et al. A Conformation‐ and Phosphorylation‐Dependent Antibody Recognizing the Paired Helical Filaments of Alzheimer's Disease , 1997, Journal of neurochemistry.
[18] Stefani N. Thomas,et al. Alzheimer Disease-specific Conformation of Hyperphosphorylated Paired Helical Filament-Tau Is Polyubiquitinated through Lys-48, Lys-11, and Lys-6 Ubiquitin Conjugation* , 2006, Journal of Biological Chemistry.
[19] Khadija Iqbal,et al. Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[20] J. Winderickx,et al. Microtubule Binding and Clustering of Human Tau-4R and Tau-P301L Proteins Isolated from Yeast Deficient in Orthologues of Glycogen Synthase Kinase-3β or cdk5* , 2006, Journal of Biological Chemistry.
[21] D. Dickson,et al. Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau , 2003, Journal of neurocytology.
[22] H. Geerts,et al. Assembly of paired helical filaments from mouse tau: implications for the neurofibrillary pathology in transgenic mouse models for Alzheimer's disease , 1999, FEBS letters.
[23] G. Riedel,et al. O1-06-04: Methylthioninium chloride (MTC) acts as a Tau aggregation inhibitor (TAI) in a cellular model and reverses Tau pathology in transgenic mouse models of Alzheimer's disease , 2008, Alzheimer's & Dementia.
[24] G. Bloom,et al. Cytoskeletal pathologies of Alzheimer disease. , 2009, Cell motility and the cytoskeleton.
[25] K. Titani,et al. Down's Syndrome: Up‐Regulation of β‐Amyloid Protein Precursor and τ mRNAs and Their Defective Coordination , 1994 .
[26] B. Winblad,et al. Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis , 2004, Acta Neuropathologica.
[27] Alejandra del C. Alonso,et al. Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules , 1996, Nature Medicine.
[28] G. Schellenberg,et al. Tau is a candidate gene for chromosome 17 frontotemporal dementia , 1998, Annals of neurology.
[29] B. Ghetti,et al. Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy. , 2008, The American journal of pathology.
[30] M. Kirschner,et al. Tau protein binds to microtubules through a flexible array of distributed weak sites , 1991, The Journal of cell biology.
[31] F. García-Sierra,et al. Regional conformational change involving phosphorylation of tau protein at the Thr231, precedes the structural change detected by Alz-50 antibody in Alzheimer's disease. , 2005, Journal of Alzheimer's disease : JAD.
[32] Khadija Iqbal,et al. Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[33] J. Ávila,et al. Polymerization of tau peptides into fibrillar structures. The effect of FTDP‐17 mutations , 1999, FEBS letters.
[34] Hideyuki Yamamoto,et al. Immunohistochemical examination of phosphorylated tau in granulovacuolar degeneration granules , 1996, Psychiatry and clinical neurosciences.
[35] G. Jicha,et al. Sequence requirements for formation of conformational variants of tau similar to those found in Alzheimer's disease , 1999, Journal of neuroscience research.
[36] M. Kirschner,et al. Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains , 1989, Molecular and cellular biology.
[37] Bin Zhang,et al. Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model , 2007, Neuron.
[38] Ana Martínez,et al. GSK-3 inhibitors: a ray of hope for the treatment of Alzheimer's disease? , 2008, Journal of Alzheimer's disease : JAD.
[39] V. Chau,et al. Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[40] Jian-Zhi Wang,et al. Proteasome inhibition increases tau accumulation independent of phosphorylation , 2009, Neurobiology of Aging.
[41] K. Jellinger,et al. Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease , 1989, Brain Research.
[42] John Calvin Reed,et al. Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities , 2008, Nature Reviews Drug Discovery.
[43] Khadija Iqbal,et al. Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[44] I. Grundke‐Iqbal,et al. Phosphoprotein Phosphatase Activities in Alzheimer Disease Brain , 1993, Journal of neurochemistry.
[45] B. Winblad,et al. P70 S6 kinase mediates tau phosphorylation and synthesis , 2006, FEBS letters.
[46] J. Winderickx,et al. Identification and isolation of a hyperphosphorylated, conformationally changed intermediate of human protein tau expressed in yeast. , 2005, Biochemistry.
[47] A. Takashima. Amyloid-beta, tau, and dementia. , 2009, Journal of Alzheimer's disease : JAD.
[48] Mari Yoshida,et al. Cellular tau pathology and immunohistochemical study of tau isoforms in sporadic tauopathies , 2006, Neuropathology : official journal of the Japanese Society of Neuropathology.
[49] V. Fried,et al. Immunochemical Properties of Ubiquitin Conjugates in the Paired Helical Filaments of Alzheimer Disease , 1989, Journal of neurochemistry.
[50] B. Hyman,et al. Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function , 2005, Science.
[51] Khadija Iqbal,et al. Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein. , 2001, The Journal of biological chemistry.
[52] George Perry,et al. Physiological regulation of tau phosphorylation during hibernation , 2008, Journal of neurochemistry.
[53] B. Winblad,et al. DEFECTIVE BRAIN MICROTUBULE ASSEMBLY IN ALZHEIMER'S DISEASE , 1986, The Lancet.
[54] Kristina D. Micheva,et al. Fragmentation of the Golgi apparatus induced by the overexpression of wild-type and mutant human tau forms in neurons. , 2005, The American journal of pathology.
[55] Yasuo Ihara,et al. Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments , 1993, Neuron.
[56] P. Bentham,et al. O3-04-07: Tau aggregation inhibitor (TAI) therapy with rember™ arrests disease progression in mild and moderate Alzheimer's disease over 50 weeks , 2008, Alzheimer's & Dementia.
[57] Khadija Iqbal,et al. Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease , 1991, Brain Research.
[58] H. Braak,et al. Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease. , 2003, The American journal of pathology.
[59] G. Lindwall,et al. Phosphorylation affects the ability of tau protein to promote microtubule assembly. , 1984, The Journal of biological chemistry.
[60] I. Grundke‐Iqbal,et al. Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1. , 1996, Brain research. Molecular brain research.
[61] H. Wiśniewski,et al. Microtubule-associated polypeptides tau are altered in Alzheimer paired helical filaments. , 1988, Brain research.
[62] Y. Ihara,et al. Ubiquitin is a component of paired helical filaments in Alzheimer's disease. , 1987, Science.
[63] G. Jicha,et al. Altered conformation of recombinant frontotemporal dementia-17 mutant tau proteins , 1999, Neuroscience Letters.
[64] I. Grundke‐Iqbal,et al. Brain Levels of Microtubule‐Associated Protein τ Are Elevated in Alzheimer's Disease: A Radioimmuno‐Slot‐Blot Assay for Nanograms of the Protein , 1992, Journal of neurochemistry.
[65] Wolfgang Härtig,et al. Reversible Paired Helical Filament-Like Phosphorylation of Tau Is an Adaptive Process Associated with Neuronal Plasticity in Hibernating Animals , 2003, The Journal of Neuroscience.
[66] I. Grundke‐Iqbal,et al. Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[67] Ronald C. Petersen,et al. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 , 1998, Nature.
[68] P. Davies,et al. Mechanism-based treatments for Alzheimer's disease , 2009, Dialogues in clinical neuroscience.
[69] I. Grundke‐Iqbal,et al. Regulation of Phosphorylation of tau by Protein Kinases in Rat Brain , 2000, Neurobiology of Aging.
[70] G. Higgins,et al. In situ hybridization of calcium/calmodulin dependent protein kinase II and tau mRNAs; species differences and relative preservation in Alzheimer's disease. , 1992, Brain research. Molecular brain research.
[71] I. Grundke‐Iqbal,et al. Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention , 2007, Journal of cellular and molecular medicine.
[72] J. Ávila,et al. GSK-3 inhibitors for Alzheimer’s disease , 2007, Expert review of neurotherapeutics.
[73] Masato Hasegawa,et al. Alzheimer-like Changes in Microtubule-associated Protein Tau Induced by Sulfated Glycosaminoglycans , 1997, The Journal of Biological Chemistry.
[74] P. Filipcik,et al. Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo , 2006, FEBS letters.
[75] E. Elliott,et al. BAG-1 Associates with Hsc70·Tau Complex and Regulates the Proteasomal Degradation of Tau Protein* , 2007, Journal of Biological Chemistry.
[76] R. Berry,et al. Relation of hippocampal phospho-SAPK/JNK granules in Alzheimer’s disease and tauopathies to granulovacuolar degeneration bodies , 2006, Acta Neuropathologica.
[77] S. Maeda,et al. Increased levels of granular tau oligomers: An early sign of brain aging and Alzheimer's disease , 2006, Neuroscience Research.
[78] I. Grundke‐Iqbal,et al. Dephosphorylation of Alzheimer Paired Helical Filaments by Protein Phosphatase-2A and −2B (*) , 1995, The Journal of Biological Chemistry.
[79] H. Wiśniewski,et al. Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. , 1986, The Journal of biological chemistry.
[80] C. Cotman,et al. The Role of Caspase Cleavage of Tau in Alzheimer Disease Neuropathology , 2005, Journal of neuropathology and experimental neurology.
[81] L. Petrucelli,et al. Akt and CHIP coregulate tau degradation through coordinated interactions , 2008, Proceedings of the National Academy of Sciences.
[82] J. Wegiel,et al. Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome. , 2008, Journal of Alzheimer's disease : JAD.
[83] P. Hof,et al. Cell-Cycle Reentry and Cell Death in Transgenic Mice Expressing Nonmutant Human Tau Isoforms , 2005, The Journal of Neuroscience.
[84] E. Mandelkow,et al. RNA stimulates aggregation of microtubule‐associated protein tau into Alzheimer‐like paired helical filaments , 1996, FEBS letters.
[85] C. Milstein,et al. Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[86] S. Yen,et al. Disease-related Modifications in Tau Affect the Interaction between Fyn and Tau* , 2005, Journal of Biological Chemistry.
[87] R. Berry,et al. Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[88] E. Mandelkow,et al. Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments. , 1999, Biochemistry.
[89] K. Davies,et al. Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress. , 2006, The Biochemical journal.
[90] H. Wiśniewski,et al. The microtubule-associated protein tau forms a triple-stranded left-hand helical polymer. , 1991, The Journal of biological chemistry.
[91] L. Yang,et al. Calpain-induced proteolysis of normal human tau and tau associated with paired helical filaments. , 1995, European journal of biochemistry.
[92] P. Coleman,et al. Neurons may live for decades with neurofibrillary tangles. , 1999, Journal of neuropathology and experimental neurology.
[93] C. Richter-Landsberg,et al. Proteolytic Stress Causes Heat Shock Protein Induction, Tau Ubiquitination, and the Recruitment of Ubiquitin to Tau-Positive Aggregates in Oligodendrocytes in Culture , 2004, The Journal of Neuroscience.
[94] J. Wegiel,et al. Increased Dosage of Dyrk1A Alters Alternative Splicing Factor (ASF)-regulated Alternative Splicing of Tau in Down Syndrome*♦ , 2008, Journal of Biological Chemistry.
[95] R. Nelson,et al. Anesthesia Leads to Tau Hyperphosphorylation through Inhibition of Phosphatase Activity by Hypothermia , 2007, The Journal of Neuroscience.
[96] I. Grundke‐Iqbal,et al. Glycosylation of microtubule–associated protein tau: An abnormal posttranslational modification in Alzheimer's disease , 1996, Nature Medicine.
[97] A Klug,et al. Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[98] R. Crowther,et al. Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans , 1996, Nature.
[99] I. Grundke‐Iqbal,et al. Promotion of Hyperphosphorylation by Frontotemporal Dementia Tau Mutations* , 2004, Journal of Biological Chemistry.
[100] I. Grundke‐Iqbal,et al. Guanosine Triphosphate Binding to β‐Subunit of Tubulin in Alzheimer's Disease Brain: Role of Microtubule‐Associated Protein τ , 1995 .
[101] I. Grundke‐Iqbal,et al. Phosphatase Activity Toward Abnormally Phosphorylated τ: Decrease in Alzheimer Disease Brain , 1995, Journal of neurochemistry.
[102] E. Hol,et al. Frameshift proteins in Alzheimer's disease and in other conformational disorders: time for the ubiquitin-proteasome system. , 2006, Journal of Alzheimer's disease : JAD.
[103] I. Grundke‐Iqbal,et al. Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[104] Khadija Iqbal,et al. Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease. , 1993, The Journal of biological chemistry.
[105] R. A. Crowther,et al. Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease , 1989, Neuron.
[106] H. Ksiȩżak-Reding,et al. Ubiquitin immunoreactivity of paired helical filaments differs in Alzheimer’s disease and corticobasal degeneration , 1998, Acta Neuropathologica.
[107] I. Gozes,et al. Decrease in levels and rates of synthesis of tubulin and actin in developing rat brain , 1977, Brain Research.
[108] M. Kirschner,et al. A protein factor essential for microtubule assembly. , 1975, Proceedings of the National Academy of Sciences of the United States of America.
[109] Alistair Burns,et al. Observations on the brains of demented old people. B.E. Tomlinson, G. Blessed and M. Roth, Journal of the Neurological Sciences (1970) 11, 205–242; (1968) 7, 331–356 , 1997 .
[110] Joshua M. Shulman,et al. Tauopathy in Drosophila: Neurodegeneration Without Neurofibrillary Tangles , 2001, Science.
[111] J. Götz,et al. Common features between diabetes mellitus and Alzheimer’s disease , 2009, Cellular and Molecular Life Sciences.
[112] I. Grundke‐Iqbal,et al. Mechanisms of tau-induced neurodegeneration , 2009, Acta Neuropathologica.
[113] J. Kuret,et al. A new molecular link between the fibrillar and granulovacuolar lesions of Alzheimer's disease. , 1999, The American journal of pathology.
[114] I. Grundke‐Iqbal,et al. Alzheimer paired helical filaments Restoration of the biological activity by dephosphorylation , 1994, FEBS letters.
[115] J. Trojanowski,et al. A68: a major subunit of paired helical filaments and derivatized forms of normal Tau. , 1991, Science.
[116] I. Grundke‐Iqbal,et al. Anesthesia induces phosphorylation of tau. , 2009, Journal of Alzheimer's disease : JAD.
[117] J. Trojanowski,et al. Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies , 2005, Acta Neuropathologica.