Abstract A hydrogen supply chain (HSC) involves multiple echelons (from the choice of energy source, production, storage, transportation, and distribution, that interact along the chain), multiple stakeholders, multiple periods from deployment to maturity, multiple objectives that reflect the economic, environmental, and social pillars of sustainable development, and finally, multiple users. The flexibility of hydrogen systems thus creates many opportunities for system design. These individual component models have then to be integrated to build the framework by which an HSC system design can be formulated and evaluated. The purpose of this chapter is to establish the configurations that should be considered and explored according to the desired goal. The criteria to be taken into account in a sustainable development context are also highlighted.