Insulin/IGF signalling and ageing: seeing the bigger picture.

[1]  M. Tatar,et al.  A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function , 2001, Science.

[2]  E. Hafen,et al.  Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein , 2001, Science.

[3]  Michael A. Costa,et al.  Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. , 2001, Genes & development.

[4]  E. Hafen,et al.  An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control , 2001, Current Biology.

[5]  L. Guarente,et al.  Genetic pathways that regulate ageing in model organisms , 2000, Nature.

[6]  Koutarou D. Kimura,et al.  Regulation of C. elegans life-span by insulinlike signaling in the nervous system. , 2000, Science.

[7]  W. Atchley,et al.  Differential longevity in mouse stocks selected for early life growth trajectory. , 2000, The journals of gerontology. Series A, Biological sciences and medical sciences.

[8]  T. Nakazawa,et al.  Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. , 2000, The Biochemical journal.

[9]  M. Ishiguro,et al.  Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans. , 2000, Biochemical and biophysical research communications.

[10]  D. Clemmons,et al.  Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. , 2000, Endocrinology.

[11]  D L Riddle,et al.  daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans. , 2000, Genes & development.

[12]  G. Ruvkun,et al.  Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant , 2000, Nature.

[13]  S. Leevers,et al.  The genetic control of organ growth: insights from Drosophila. , 2000, Current opinion in genetics & development.

[14]  A. Bartke Delayed aging in Ames dwarf mice. Relationships to endocrine function and body size. , 2000, Results and problems in cell differentiation.

[15]  S. Hekimi The Molecular Genetics of Aging , 2000, Results and Problems in Cell Differentiation.

[16]  J. Apfeld,et al.  Regulation of lifespan by sensory perception in Caenorhabditis elegans , 1999, Nature.

[17]  S. Bennett,et al.  Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals. , 1999, The journals of gerontology. Series A, Biological sciences and medical sciences.

[18]  Pier Paolo Pandolfi,et al.  The p66shc adaptor protein controls oxidative stress response and life span in mammals , 1999, Nature.

[19]  J. Vanfleteren,et al.  Mechanisms of life span determination in Caenorhabditis elegans☆ , 1999, Neurobiology of Aging.

[20]  Y Honda,et al.  The daf‐2 gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression in Caenorhabditis elegans , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[21]  Cynthia Kenyon,et al.  Signals from the reproductive system regulate the lifespan of C. elegans , 1999, Nature.

[22]  T. Battelino,et al.  The "Little People" of the Island of Krk - Revisited. Etiology of Hypopituitarism Revealed , 1999 .

[23]  J. Apfeld,et al.  Cell Nonautonomy of C. elegans daf-2 Function in the Regulation of Diapause and Life Span , 1998, Cell.

[24]  D. Riddle,et al.  Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. , 1998, Genetics.

[25]  J. Culotti,et al.  daf-12 regulates developmental age and the dauer alternative in Caenorhabditis elegans. , 1998, Development.

[26]  A Bairoch,et al.  New insulin-like proteins with atypical disulfide bond pattern characterized in Caenorhabditis elegans by comparative sequence analysis and homology modeling. , 1998, Genome research.

[27]  D. Riddle C. Elegans II , 1998 .

[28]  T. Wagner,et al.  A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[29]  C. Kenyon,et al.  daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. , 1997, Science.

[30]  G. Ruvkun,et al.  The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans , 1997, Nature.

[31]  Koutarou D. Kimura,et al.  daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. , 1997, Science.

[32]  R. Raff,et al.  Evidence for a clade of nematodes, arthropods and other moulting animals , 1997, Nature.

[33]  L. Glickman,et al.  Comparative longevity of pet dogs and humans: implications for gerontology research. , 1997, The journals of gerontology. Series A, Biological sciences and medical sciences.

[34]  R. Miskin,et al.  Transgenic mice overexpressing urokinase-type plasminogen activator in the brain exhibit reduced food consumption, body weight and size, and increased longevity. , 1997, The journals of gerontology. Series A, Biological sciences and medical sciences.

[35]  Donald L Riddle,et al.  Genetic and Environmental Regulation of Dauer Larva Development , 1997 .

[36]  Andrzej Bartke,et al.  Dwarf mice and the ageing process , 1996, Nature.

[37]  L. Partridge,et al.  Female fitness in Drosophila melanogaster: an interaction between the effect of nutrition and of encounter rate with males , 1996, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[38]  R. Weindruch,et al.  Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[39]  Mark D. Johnson,et al.  Early neonatal death in mice homozygous for a null allele of the insulin receptor gene , 1996, Nature Genetics.

[40]  N. Wolf,et al.  Caloric restriction: conservation of cellular replicative capacity in vitro accompanies life-span extension in mice. , 1995, Experimental cell research.

[41]  D. Riddle,et al.  Genes that regulate both development and longevity in Caenorhabditis elegans. , 1995, Genetics.

[42]  J. Burnside,et al.  Dysfunctional growth hormone receptor in a strain of sex-linked dwarf chicken: evidence for a mutation in the intracellular domain. , 1994, The Journal of endocrinology.

[43]  C. Kenyon,et al.  A C. elegans mutant that lives twice as long as wild type , 1993, Nature.

[44]  A. Bartke,et al.  Premature ageing in transgenic mice expressing different growth hormone genes. , 1993, Journal of reproduction and fertility. Supplement.

[45]  Simeon I. Taylor,et al.  Homozygous deletion of the human insulin receptor gene results in leprechaunism , 1993, Nature Genetics.

[46]  L. Storms,et al.  Impact of height and weight on life span. , 1992, Bulletin of the World Health Organization.

[47]  C. Breese,et al.  Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins. , 1991, Journal of gerontology.

[48]  T. Wagner,et al.  Fertility of transgenic female mice expressing bovine growth hormone or human growth hormone variant genes. , 1991, Biology of reproduction.

[49]  D. Rudman,et al.  Effects of human growth hormone in men over 60 years old. , 1990, The New England journal of medicine.

[50]  R W Hart,et al.  Effect of chronic caloric restriction on the circadian regulation of physiological and behavioral variables in old male B6C3F1 mice. , 1990, Chronobiology international.

[51]  C M McCay,et al.  The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935. , 1935, Nutrition.

[52]  M. Binoux,et al.  Statural development parallels IGF I levels in subjects of constitutionally variant stature. , 1987, Acta endocrinologica.

[53]  E. Froesch,et al.  Body size parallels insulin-like growth factor I levels but not growth hormone secretory capacity. , 1984, Acta endocrinologica.

[54]  R. Weindruch,et al.  Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. , 1982, Science.

[55]  M. Klass,et al.  Aging in the nematode Caenorhabditis elegans: Major biological and environmental factors influencing life span , 1977, Mechanisms of Ageing and Development.

[56]  L. Martinet,et al.  Preliminary results on plasma progesterone levels during pregnancy and superfetation in the hare, Lepus Europaeus. , 1976, Journal of reproduction and fertility.

[57]  R. C. Roberts The lifetime growth and reproduction of selected strains of mice , 1961, Heredity.