Antimicrobial peptides and the skin immune defense system.

[1]  C. Zouboulis,et al.  Sebocytes express functional cathelicidin antimicrobial peptides and can act to kill propionibacterium acnes. , 2008, The Journal of investigative dermatology.

[2]  D. O'Connor,et al.  The neuroendocrine peptide catestatin is a cutaneous antimicrobial and induced in the skin after injury. , 2008, The Journal of investigative dermatology.

[3]  R. Gallo,et al.  Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3. , 2008, The Journal of investigative dermatology.

[4]  J. Moan,et al.  Addressing the health benefits and risks, involving vitamin D or skin cancer, of increased sun exposure , 2008, Proceedings of the National Academy of Sciences.

[5]  T. Schwarz.  25 years of UV‐induced Immunosuppression Mediated by T Cells—From Disregarded T Suppressor Cells to Highly Respected Regulatory T Cells † , 2007, Photochemistry and photobiology.

[6]  André Reis,et al.  Psoriasis is associated with increased beta-defensin genomic copy number. , 2008, Nature genetics.

[7]  I. Nagaoka,et al.  Cathelicidin LL‐37 induces the generation of reactive oxygen species and release of human α‐defensins from neutrophils , 2007, The British journal of dermatology.

[8]  Robert E. W. Hancock,et al.  Host Defense Peptide LL-37, in Synergy with Inflammatory Mediator IL-1β, Augments Immune Responses by Multiple Pathways1 , 2007, The Journal of Immunology.

[9]  P. Dhawan,et al.  Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D(3). , 2007, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

[10]  T. Ruzicka,et al.  S100A15, an antimicrobial protein of the skin: regulation by E. coli through Toll-like receptor 4. , 2007, The Journal of investigative dermatology.

[11]  I. Mellman,et al.  Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide , 2007, Nature.

[12]  A. Hovnanian,et al.  Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea , 2007, Nature Medicine.

[13]  D. Bikle.  What is new in vitamin D: 2006–2007 , 2007, Current opinion in rheumatology.

[14]  Y. Helfrich,et al.  Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. , 2007, The Journal of clinical investigation.

[15]  R. Gallo,et al.  Expanding the roles of antimicrobial peptides in skin: alarming and arming keratinocytes. , 2007, The Journal of investigative dermatology.

[16]  K. Sayama,et al.  Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. , 2007, The Journal of investigative dermatology.

[17]  A. Di Nardo,et al.  Cathelicidin Antimicrobial Peptides Block Dendritic Cell TLR4 Activation and Allergic Contact Sensitization1 , 2007, The Journal of Immunology.

[18]  G. de la Rosa,et al.  Alarmins initiate host defense. , 2007, Advances in experimental medicine and biology.

[19]  Henry Lin,et al.  The FASEB Journal • Research Communication Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin , 2022 .

[20]  R. Gallo,et al.  Control of the innate epithelial antimicrobial response is cell‐type specific and dependent on relevant microenvironmental stimuli , 2006, Immunology.

[21]  P. Chambon,et al.  Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[22]  T. Hökfelt,et al.  The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection , 2006, Nature Medicine.

[23]  M. Flaig,et al.  Cathelicidin deficiency predisposes to eczema herpeticum. , 2006, The Journal of allergy and clinical immunology.

[24]  J. Adams,et al.  Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response , 2006, Science.

[25]  James F. Jones,et al.  Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus. , 2006, Immunity.

[26]  R. Gallo,et al.  Antimicrobial peptides: an essential component of the skin defensive barrier. , 2006, Current topics in microbiology and immunology.

[27]  A. Yoshimura,et al.  Induction of Keratinocyte Migration via Transactivation of the Epidermal Growth Factor Receptor by the Antimicrobial Peptide LL-371 , 2005, The Journal of Immunology.

[28]  V. Nizet,et al.  Keratinocyte Production of Cathelicidin Provides Direct Activity against Bacterial Skin Pathogens , 2005, Infection and Immunity.

[29]  I. Nagaoka,et al.  The Human β-Defensins (-1, -2, -3, -4) and Cathelicidin LL-37 Induce IL-18 Secretion through p38 and ERK MAPK Activation in Primary Human Keratinocytes1 , 2005, The Journal of Immunology.

[30]  R. Gallo,et al.  Anti-fungal activity of cathelicidins and their potential role in Candida albicans skin infection. , 2005, The Journal of investigative dermatology.

[31]  V. Nizet,et al.  Cutaneous defense mechanisms by antimicrobial peptides. , 2005, The Journal of investigative dermatology.

[32]  H. Koeffler,et al.  Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up‐regulated in myeloid cells by 1,25‐dihydroxyvitamin D3 , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[33]  H. Törmä,et al.  Vitamin D induces the antimicrobial protein hCAP18 in human skin. , 2005, The Journal of investigative dermatology.

[34]  M. Kagnoff,et al.  Cathelicidin Mediates Innate Intestinal Defense against Colonization with Epithelial Adherent Bacterial Pathogens1 , 2005, The Journal of Immunology.

[35]  A. Di Nardo,et al.  Keratinocytes store the antimicrobial peptide cathelicidin in lamellar bodies. , 2005, The Journal of investigative dermatology.

[36]  J. Schröder,et al.  Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection , 2005, Nature Immunology.

[37]  R. Gallo,et al.  Expression and Secretion of Cathelicidin Antimicrobial Peptides in Murine Mammary Glands and Human Milk , 2005, Pediatric Research.

[38]  Glenville Jones,et al.  Enzymes involved in the activation and inactivation of vitamin D. , 2004, Trends in biochemical sciences.

[39]  John H. White,et al.  Cutting Edge: 1,25-Dihydroxyvitamin D3 Is a Direct Inducer of Antimicrobial Peptide Gene Expression1 , 2004, The Journal of Immunology.

[40]  D. Bikle.  Vitamin D regulated keratinocyte differentiation , 2004, Journal of cellular biochemistry.

[41]  P. Elias,et al.  Mice lacking 25OHD 1α-hydroxylase demonstrate decreased epidermal differentiation and barrier function , 2004, The Journal of Steroid Biochemistry and Molecular Biology.

[42]  A. Burlingame,et al.  Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in VDR transactivation during keratinocyte differentiation , 2004, The Journal of Steroid Biochemistry and Molecular Biology.

[43]  M. Lebwohl,et al.  Combination therapy to treat moderate to severe psoriasis. , 2004, Journal of the American Academy of Dermatology.

[44]  G. Plewig,et al.  BsmI Polymorphism of the Vitamin D Receptor Gene in Patients with the Fulminant Course of Rosacea Conglobata (Rosacea Fulminans) , 2004, The Journal of dermatology.

[45]  R. Gallo,et al.  Antimicrobial Defense Cathelicidins for Enhanced Topical Postsecretory Processing Generates Multiple , 2004 .

[46]  T. Tezuka,et al.  Presence of bactericidal/permeability‐increasing protein in human and rat skin , 2004, Experimental dermatology.

[47]  J. Dhesi,et al.  Hypovitaminosis D in Older Adults , 2003, Gerontology.

[48]  P. C. White,et al.  Supernatants of Pseudomonas aeruginosa induce the Pseudomonas‐specific antibiotic elafin in human keratinocytes , 2003, Experimental dermatology.

[49]  S. Zahler,et al.  An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. , 2003, The Journal of clinical investigation.

[50]  V. Nizet,et al.  Antimicrobial and protease inhibitory functions of the human cathelicidin (hCAP18/LL-37) prosequence. , 2003, The Journal of investigative dermatology.

[51]  D. Aunis,et al.  The N‐ and C‐terminal fragments of ubiquitin are important for the antimicrobial activities , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[52]  A. Vitiello,et al.  Cutting Edge: Mast Cell Antimicrobial Activity Is Mediated by Expression of Cathelicidin Antimicrobial Peptide 1 , 2003, The Journal of Immunology.

[53]  A. Amoroso,et al.  Review: Antimicrobial and immunoregulatory functions of lactoferrin and its potential therapeutic application , 2002, Journal of endotoxin research.

[54]  H. Brismar,et al.  The newborn infant is protected by an innate antimicrobial barrier: peptide antibiotics are present in the skin and vernix caseosa , 2002, The British journal of dermatology.

[55]  M. Selsted,et al.  Antimicrobial Peptides from Human Platelets , 2002, Infection and Immunity.

[56]  J. Schröder,et al.  RNase 7, a Novel Innate Immune Defense Antimicrobial Protein of Healthy Human Skin* , 2002, The Journal of Biological Chemistry.

[57]  C. Garbe,et al.  Cathelicidin anti-microbial peptide expression in sweat, an innate defense system for the skin. , 2002, The Journal of investigative dermatology.

[58]  Tomas Ganz,et al.  Endogenous antimicrobial peptides and skin infections in atopic dermatitis. , 2002, The New England journal of medicine.

[59]  R. Granstein,et al.  Langerhans cell expression of neuropeptide Y and peptide YY , 2002, Neuropeptides.

[60]  H. Hammad,et al.  Presence of chromogranin-derived antimicrobial peptides in plasma during coronary artery bypass surgery and evidence of an immune origin of these peptides. , 2002, Blood.

[61]  D. Carr,et al.  Direct antimicrobial properties of substance P. , 2002, Life sciences.

[62]  Nikolaus Blin,et al.  Dermcidin: a novel human antibiotic peptide secreted by sweat glands , 2001, Nature Immunology.

[63]  Takaaki Ohtake,et al.  Innate antimicrobial peptide protects the skin from invasive bacterial infection , 2001, Nature.

[64]  M. Meurer,et al.  UVB-Induced Conversion of 7-Dehydrocholesterol to 1α,25-Dihydroxyvitamin D3 in an In Vitro Human Skin Equivalent Model , 2001 .

[65]  M. Burdick,et al.  Cutting Edge: IFN-Inducible ELR− CXC Chemokines Display Defensin-Like Antimicrobial Activity1 , 2001, The Journal of Immunology.

[66]  V. Nizet,et al.  Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A Streptococcus. , 2001, The Journal of investigative dermatology.

[67]  O. Chertov,et al.  Participation of mammalian defensins and cathelicidins in anti‐microbial immunity: receptors and activities of human defensins and cathelicidin (LL‐37) , 2001, Journal of leukocyte biology.

[68]  I. Nagaoka,et al.  Evaluation of the effects of peptide antibiotics human β‐defensins‐1/‐2 and LL‐37 on histamine release and prostaglandin D2 production from mast cells , 2001 .

[69]  I. Nagaoka,et al.  Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells. , 2001, European journal of immunology.

[70]  H. Jörnvall,et al.  The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations. , 2000, Blood.

[71]  O. Conneely,et al.  Regulation of epidermal Langerhans cell migration by lactoferrin , 2000, Immunology.

[72]  J. M. Lipton,et al.  Antimicrobial effects of α‐MSH peptides , 2000 .

[73]  J. M. Lipton,et al.  Antimicrobial effects of alpha-MSH peptides. , 2000, Journal of Leukocyte Biology.

[74]  C. Haslett,et al.  Elafin (elastase‐specific inhibitor) has anti‐microbial activity against Gram‐positive and Gram‐negative respiratory pathogens , 1999, FEBS letters.

[75]  R. Allaker,et al.  An investigation into the antimicrobial effects of adrenomedullin on members of the skin, oral, respiratory tract and gut microflora. , 1999, FEMS immunology and medical microbiology.

[76]  J. Meis,et al.  Induction of SLPI (ALP/HUSI-I) in epidermal keratinocytes. , 1998, The Journal of investigative dermatology.

[77]  H. Heng,et al.  Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation. , 1998, Gene.

[78]  E. Veerman,et al.  Cystatin and cystatin-derived peptides have antibacterial activity against the pathogen Porphyromonas gingivalis. , 1998, Biological chemistry.

[79]  T. Ganz,et al.  An antimicrobial activity of cytolytic T cells mediated by granulysin. , 1998, Science.

[80]  K. Bailey,et al.  Potential Role of Epithelial Cell-Derived Histone H1 Proteins in Innate Antimicrobial Defense in the Human Gastrointestinal Tract , 1998, Infection and Immunity.

[81]  K. Dyer,et al.  Eosinophil cationic protein/RNase 3 is another RNase A-family ribonuclease with direct antiviral activity. , 1998, Nucleic acids research.

[82]  K. Dyer,et al.  Recombinant human eosinophil-derived neurotoxin/RNase 2 functions as an effective antiviral agent against respiratory syncytial virus. , 1998, The Journal of infectious diseases.

[83]  J. Schröder,et al.  A peptide antibiotic from human skin , 1997, Nature.

[84]  H. Wigzell,et al.  The Expression of the Gene Coding for the Antibacterial Peptide LL-37 Is Induced in Human Keratinocytes during Inflammatory Disorders* , 1997, The Journal of Biological Chemistry.

[85]  A. Johnsen,et al.  hCAP‐18, a cathelin/pro‐bactenecin‐like protein of human neutrophil specific granules , 1995, FEBS letters.

[86]  J. Odeberg,et al.  FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[87]  M. Klagsbrun,et al.  Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[88]  R. Lehrer,et al.  Purification of cysteine-rich bioactive peptides from leukocytes by continuous acid-urea-polyacrylamide gel electrophoresis. , 1993, Analytical biochemistry.

[89]  D. Bikle,et al.  Regulation of 1,25-dihydroxyvitamin D production in human keratinocytes by interferon-gamma. , 1989, Endocrinology.

[90]  W. Edmundson.  Chrome ulcers of the skin and nasal septum and their relation to patch testing. , 1951, The Journal of investigative dermatology.