Selenoproteins: Antioxidant selenoenzymes and beyond.

[1]  D. Townsend,et al.  Oxidative stress, redox regulation and diseases of cellular differentiation. , 2015, Biochimica et biophysica acta.

[2]  Chao Zeng,et al.  The association between dietary selenium intake and diabetes: a cross-sectional study among middle-aged and older adults , 2015, Nutrition Journal.

[3]  J. Quevedo,et al.  Ebselen Attenuates Lung Injury in Experimental Model of Carrageenan-Induced Pleurisy in Rats , 2015, Inflammation.

[4]  M. Qorbani,et al.  A Randomized, Placebo-Controlled Trial of Selenium Supplementation in Patients With Type 2 Diabetes: Effects on Glucose Homeostasis, Oxidative Stress, and Lipid Profile , 2014, American journal of therapeutics.

[5]  V. Winfrey,et al.  Selenoprotein P and apolipoprotein E receptor‐2 interact at the blood‐brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[6]  H. Steinbrenner,et al.  Upregulation of the thioredoxin-dependent redox system during differentiation of 3T3-L1 cells to adipocytes , 2014, Biological chemistry.

[7]  H. Steinbrenner,et al.  Selenium and Selenoproteins in Inflammatory Bowel Diseases and Experimental Colitis , 2014, Inflammatory bowel diseases.

[8]  S. Mao,et al.  Selenium supplementation and the risk of type 2 diabetes mellitus: a meta-analysis of randomized controlled trials , 2014, Endocrine.

[9]  H. Sies Role of Metabolic H2O2 Generation , 2014, The Journal of Biological Chemistry.

[10]  K. Khanna,et al.  Selenoprotein S is a marker but not a regulator of endoplasmic reticulum stress in intestinal epithelial cells. , 2014, Free radical biology & medicine.

[11]  Nicholette D. Palmer,et al.  Genetic variants in selenoprotein P plasma 1 gene (SEPP1) are associated with fasting insulin and first phase insulin response in Hispanics. , 2014, Gene.

[12]  J. Yun,et al.  Glutathione peroxidase mimic ebselen improves glucose-stimulated insulin secretion in murine islets. , 2014, Antioxidants & redox signaling.

[13]  Wei Zhang,et al.  High selenium impairs hepatic insulin sensitivity through opposite regulation of ROS. , 2014, Toxicology letters.

[14]  H. Bidmon,et al.  Intestinal selenoprotein P in epithelial cells and in plasma cells. , 2014, Archives of biochemistry and biophysics.

[15]  S. Stranges,et al.  Epidemiology of selenium and type 2 diabetes: can we make sense of it? , 2013, Free radical biology & medicine.

[16]  H. Steinbrenner Interference of selenium and selenoproteins with the insulin-regulated carbohydrate and lipid metabolism. , 2013, Free radical biology & medicine.

[17]  S. Kaneko,et al.  Metformin Suppresses Expression of the Selenoprotein P Gene via an AMP-activated Kinase (AMPK)/FoxO3a Pathway in H4IIEC3 Hepatocytes* , 2013, The Journal of Biological Chemistry.

[18]  M. Parnham,et al.  The early research and development of ebselen. , 2013, Biochemical pharmacology.

[19]  D. Bernlohr,et al.  Ebselen Treatment Prevents Islet Apoptosis, Maintains Intranuclear Pdx-1 and MafA Levels, and Preserves β-Cell Mass and Function in ZDF Rats , 2013, Diabetes.

[20]  H. Steinbrenner,et al.  Selenium homeostasis and antioxidant selenoproteins in brain: implications for disorders in the central nervous system. , 2013, Archives of biochemistry and biophysics.

[21]  Kee-Hong Kim,et al.  Dexamethasone-induced selenoprotein S degradation is required for adipogenesis , 2013, Journal of Lipid Research.

[22]  Shenika V. Poindexter,et al.  Dietary Selenium Deficiency Exacerbates DSS-Induced Epithelial Injury and AOM/DSS-Induced Tumorigenesis , 2013, PloS one.

[23]  H. Steinbrenner,et al.  Toward understanding success and failures in the use of selenium for cancer prevention. , 2013, Antioxidants & redox signaling.

[24]  H. J. Yoo,et al.  Increased Selenoprotein P Levels in Subjects with Visceral Obesity and Nonalcoholic Fatty Liver Disease , 2013, Diabetes & metabolism journal.

[25]  Nisha Singh,et al.  A safe lithium mimetic for bipolar disorder , 2012, Nature Communications.

[26]  X. Lei,et al.  Selenium and diabetes--evidence from animal studies. , 2012, Free radical biology & medicine.

[27]  H. Ressom,et al.  iTRAQ-based quantitative protein expression profiling and MRM verification of markers in type 2 diabetes. , 2012, Journal of proteome research.

[28]  R. Brigelius-Flohé,et al.  The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signalling in the intestinal epithelium. , 2012, Biochimica et biophysica acta.

[29]  H. Steinbrenner,et al.  Supranutritional selenium induces alterations in molecular targets related to energy metabolism in skeletal muscle and visceral adipose tissue of pigs. , 2012, Journal of inorganic biochemistry.

[30]  Tanya M. Teslovich,et al.  Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes , 2012, Nature Genetics.

[31]  X. Lei,et al.  A high-selenium diet induces insulin resistance in gestating rats and their offspring. , 2012, Free radical biology & medicine.

[32]  J. Hesketh,et al.  The influence of selenium and selenoprotein gene variants on colorectal cancer risk. , 2012, Mutagenesis.

[33]  M. Lazar,et al.  Forming functional fat: a growing understanding of adipocyte differentiation , 2011, Nature Reviews Molecular Cell Biology.

[34]  J. Eisenbart,et al.  Mitochondrial complex III ROS regulate adipocyte differentiation. , 2011, Cell metabolism.

[35]  T. Aw,et al.  Redox biology of the intestine , 2011, Free radical research.

[36]  F. Cappuccio,et al.  Associations of selenium status with cardiometabolic risk factors: an 8-year follow-up analysis of the Olivetti Heart study. , 2011, Atherosclerosis.

[37]  H. J. Yoo,et al.  Serum selenoprotein P levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis. , 2011, The Journal of clinical endocrinology and metabolism.

[38]  H. Steinbrenner,et al.  Delaying of insulin signal transduction in skeletal muscle cells by selenium compounds. , 2011, Journal of inorganic biochemistry.

[39]  R. de Cabo,et al.  Oxidative Stress Accumulates in Adipose Tissue during Aging and Inhibits Adipogenesis , 2011, PloS one.

[40]  R. Andriantsitohaina,et al.  Dynamic regulation of mitochondrial network and oxidative functions during 3T3-L1 fat cell differentiation , 2011, Journal of Physiology and Biochemistry.

[41]  H. Bidmon,et al.  Induction of Glutathione Peroxidase 4 Expression during Enterocytic Cell Differentiation* , 2011, The Journal of Biological Chemistry.

[42]  H. Steinbrenner,et al.  High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism , 2010, Journal of clinical biochemistry and nutrition.

[43]  Xiaoli Chen,et al.  Reducing selenoprotein P expression suppresses adipocyte differentiation as a result of increased preadipocyte inflammation. , 2011, American journal of physiology. Endocrinology and metabolism.

[44]  S. Florian,et al.  Loss of GPx2 increases apoptosis, mitosis, and GPx1 expression in the intestine of mice. , 2010, Free radical biology & medicine.

[45]  M. Honda,et al.  A liver-derived secretory protein, selenoprotein P, causes insulin resistance. , 2010, Cell metabolism.

[46]  H. Steinbrenner,et al.  Proinflammatory cytokines down-regulate intestinal selenoprotein P biosynthesis via NOS2 induction. , 2010, Free radical biology & medicine.

[47]  D. Byrne,et al.  Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects. , 2010, The American journal of clinical nutrition.

[48]  V. Gladyshev,et al.  Structure-function relations, physiological roles, and evolution of mammalian ER-resident selenoproteins. , 2010, Antioxidants & redox signaling.

[49]  H. Steinbrenner,et al.  Protection against reactive oxygen species by selenoproteins. , 2009, Biochimica et biophysica acta.

[50]  R. Burk,et al.  Selenoprotein P-expression, functions, and roles in mammals. , 2009, Biochimica et biophysica acta.

[51]  H. Steinbrenner,et al.  Attenuation of hepatic expression and secretion of selenoprotein P by metformin. , 2009, Biochemical and biophysical research communications.

[52]  M. Matsuda,et al.  Dysregulated glutathione metabolism links to impaired insulin action in adipocytes. , 2009, American journal of physiology. Endocrinology and metabolism.

[53]  E. Guallar,et al.  Serum Selenium Concentrations and Diabetes in U.S. Adults: National Health and Nutrition Examination Survey (NHANES) 2003–2004 , 2009, Environmental health perspectives.

[54]  Hyeonjin Choi,et al.  Reactive Oxygen Species Facilitate Adipocyte Differentiation by Accelerating Mitotic Clonal Expansion* , 2009, Journal of Biological Chemistry.

[55]  Jeen-Woo Park,et al.  The use of ebselen for radioprotection in cultured cells and mice. , 2009, Free radical biology & medicine.

[56]  R. Brandes,et al.  Nox4 Acts as a Switch Between Differentiation and Proliferation in Preadipocytes , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[57]  H. Steinbrenner,et al.  Selenoprotein P expression is controlled through interaction of the coactivator PGC‐1α with FoxO1a and hepatocyte nuclear factor 4α transcription factors , 2008, Hepatology.

[58]  K. Park,et al.  Dysregulation of adipose glutathione peroxidase 3 in obesity contributes to local and systemic oxidative stress. , 2008, Molecular endocrinology.

[59]  W. Ferris,et al.  Selenium stimulates pancreatic beta‐cell gene expression and enhances islet function , 2008, FEBS letters.

[60]  X. D. Wang,et al.  Molecular mechanisms for hyperinsulinaemia induced by overproduction of selenium-dependent glutathione peroxidase-1 in mice , 2008, Diabetologia.

[61]  V. Winfrey,et al.  Megalin Mediates Selenoprotein P Uptake by Kidney Proximal Tubule Epithelial Cells* , 2008, Journal of Biological Chemistry.

[62]  H. Steinbrenner,et al.  Stimulation of selenoprotein P promoter activity in hepatoma cells by FoxO1a transcription factor. , 2008, Biochemical and biophysical research communications.

[63]  M. Trevisan,et al.  Effects of Long-Term Selenium Supplementation on the Incidence of Type 2 Diabetes , 2007, Annals of Internal Medicine.

[64]  Fukun W. Hoffmann,et al.  The selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply , 2007, Nucleic acids research.

[65]  Kum Kum Khanna,et al.  From selenium to selenoproteins: synthesis, identity, and their role in human health. , 2007, Antioxidants & redox signaling.

[66]  S. Nagdas,et al.  Apolipoprotein E Receptor-2 (ApoER2) Mediates Selenium Uptake from Selenoprotein P by the Mouse Testis* , 2007, Journal of Biological Chemistry.

[67]  W. de Lau,et al.  WNT signaling in the normal intestine and colorectal cancer. , 2007, Frontiers in bioscience : a journal and virtual library.

[68]  O. MacDougald,et al.  Adipocyte differentiation from the inside out , 2006, Nature Reviews Molecular Cell Biology.

[69]  H. Steinbrenner,et al.  Involvement of selenoprotein P in protection of human astrocytes from oxidative damage. , 2006, Free radical biology & medicine.

[70]  C. Davis,et al.  Both selenoproteins and low molecular weight selenocompounds reduce colon cancer risk in mice with genetically impaired selenoprotein expression , 2006, The Journal of nutrition.

[71]  H. Steinbrenner,et al.  Selenoprotein P protects endothelial cells from oxidative damage by stimulation of glutathione peroxidase expression and activity , 2006, Free radical research.

[72]  J. Köhrle,et al.  Selenium, the thyroid, and the endocrine system. , 2005, Endocrine reviews.

[73]  H. Motoshima,et al.  Hyperglycemia potentiates H2O2 production in adipocytes and enhances insulin signal transduction: Potential role for oxidative inhibition of thiol-sensitive protein-tyrosine phosphatases , 2005 .

[74]  T. Emanuelli,et al.  Dimethyl Sulfoxide and Ebselen Prevent Convulsions Induced by 5-Aminolevulinic Acid , 2004, Neurochemical Research.

[75]  N. Holbrook,et al.  Singlet Oxygen-induced Attenuation of Growth Factor Signaling: Possible Role of Ceramides , 2004, Free radical research.

[76]  F. Liu,et al.  Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[77]  H. Steinbrenner,et al.  Selenoprotein P Protects Low-density Lipoprotein Against Oxidation , 2004, Free radical research.

[78]  R. Guigó,et al.  Characterization of Mammalian Selenoproteomes , 2003, Science.

[79]  D. Graham,et al.  Antioxidant ebselen reduces oxidative damage in focal cerebral ischemia. , 2003, Free radical biology & medicine.

[80]  D. Arango,et al.  A gene expression profile that defines colon cell maturation in vitro. , 2002, Cancer research.

[81]  E. Stadtman,et al.  Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity. , 2002, Biochemical and biophysical research communications.

[82]  Guillaume Adelmant,et al.  Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1 , 2001, Nature.

[83]  D. Graham,et al.  Ebselen Protects Both Gray and White Matter in a Rodent Model of Focal Cerebral Ischemia , 2001, Stroke.

[84]  R. Caprioli,et al.  Heparin-binding Histidine and Lysine Residues of Rat Selenoprotein P* , 2001, The Journal of Biological Chemistry.

[85]  I. Rusyn,et al.  Ebselen prevents early alcohol-induced liver injury in rats. , 2001, Free radical biology & medicine.

[86]  S. Florian,et al.  Cellular and subcellular localization of gastrointestinal glutathione peroxidase in normal and malignant human intestinal tissue , 2001, Free radical research.

[87]  R. Walther,et al.  Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity. , 2000, The Journal of biological chemistry.

[88]  K. Zilles,et al.  Ebselen lowers plasma interleukin-6 levels and glial heme oxygenase-1 expression after focal photothrombotic brain ischemia. , 2000, Archives of biochemistry and biophysics.

[89]  G. Arteel,et al.  Binding of Selenoprotein P to Heparin: Characterization with Surface Plasmon Resonance , 2000, Biological chemistry.

[90]  A. Rudich,et al.  Oxidative Stress Disrupts Insulin-induced Cellular Redistribution of Insulin Receptor Substrate-1 and Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes , 1999, The Journal of Biological Chemistry.

[91]  Yoshiro Saito,et al.  Selenoprotein P in Human Plasma as an Extracellular Phospholipid Hydroperoxide Glutathione Peroxidase , 1999, The Journal of Biological Chemistry.

[92]  J. Barrett,et al.  Purification from Bovine Serum of a Survival-Promoting Factor for Cultured Central Neurons and Its Identification as Selenoprotein-P , 1998, The Journal of Neuroscience.

[93]  G. Arteel,et al.  Protection by selenoprotein P in human plasma against peroxynitrite-mediated oxidation and nitration. , 1998, Biological chemistry.

[94]  G. Combs,et al.  Cellular glutathione peroxidase is the mediator of body selenium to protect against paraquat lethality in transgenic mice. , 1998, The Journal of nutrition.

[95]  K. Takakura,et al.  Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group. , 1998, Stroke.

[96]  L. Klotz,et al.  Glutathione Peroxidase Protects against Peroxynitrite-mediated Oxidations , 1997, The Journal of Biological Chemistry.

[97]  Bruce W. Turnbull,et al.  Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin: A Randomized Controlled Trial , 1996 .

[98]  H. Sies,et al.  Attenuation of oxidation and nitration reactions of peroxynitrite by selenomethionine, selenocystine and ebselen. , 1996, The Biochemical journal.

[99]  H. Masumoto,et al.  The reaction of ebselen with peroxynitrite. , 1996, Chemical research in toxicology.

[100]  T. Schewe Molecular actions of ebselen--an antiinflammatory antioxidant. , 1995, General pharmacology.

[101]  M. Hamberg,et al.  Human Thioredoxin Reductase Directly Reduces Lipid Hydroperoxides by NADPH and Selenocystine Strongly Stimulates the Reaction via Catalytically Generated Selenols(*) , 1995, The Journal of Biological Chemistry.

[102]  G. Schuch,et al.  Transport of ebselen in plasma and its transfer to binding sites in the hepatocyte. , 1994, Biochemical pharmacology.

[103]  A. Wendel,et al.  Strong inhibition of mammalian lipoxygenases by the antiinflammatory seleno-organic compound ebselen in the absence of glutathione. , 1994, Biochemical pharmacology.

[104]  J. Gordon,et al.  Cell lineage-specific and differentiation-dependent patterns of CCAAT/enhancer binding protein alpha expression in the gut epithelium of normal and transgenic mice. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[105]  H. Sies,et al.  Inhibition of superoxide and nitric oxide release and protection from reoxygenation injury by ebselen in rat kupffer cells , 1992, Hepatology.

[106]  G. Kass,et al.  Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C? , 1989, Biochemical pharmacology.

[107]  H. Fischer,et al.  A novel biologically active selenoorganic compound. VIII. Biotransformation of ebselen. , 1988, Xenobiotica; the fate of foreign compounds in biological systems.

[108]  F. Ursini,et al.  Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51). , 1988, Biochemical pharmacology.

[109]  H. Sies,et al.  A novel biologically active selenooorganic compound--VII. Biotransformation of ebselen in perfused rat liver. , 1988, Biochemical pharmacology.

[110]  A. Wendel,et al.  A novel biologically active seleno-organic compound--II. Activity of PZ 51 in relation to glutathione peroxidase. , 1984, Biochemical pharmacology.

[111]  E. Cadenas,et al.  A novel biologically active seleno-organic compound--I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen). , 1984, Biochemical pharmacology.

[112]  M. Parnham,et al.  A novel biologically active seleno-organic compound--III. Effects of PZ 51 (Ebselen) on glutathione peroxidase and secretory activities of mouse macrophages. , 1984, Biochemical pharmacology.

[113]  H. Sies,et al.  A role of mitochondrial glutathione peroxidase in modulating mitochondrial oxidations in liver. , 1978, European journal of biochemistry.

[114]  L. Flohé,et al.  Glutathione peroxidase: A selenoenzyme , 1973, FEBS letters.

[115]  H. Ganther,et al.  Selenium: Biochemical Role as a Component of Glutathione Peroxidase , 1973, Science.