Plasticity of cortical activation related to working memory during training.

OBJECTIVE Although it is well established that cerebral activation increases with higher task load, the potential effects of training have been investigated over brief periods only. Training is of potential clinical relevance since training programs are an essential part of psychiatric therapy. METHOD Cerebral activation during a visual spatial working memory task was examined before, during, and after 4 weeks of daily training in nine healthy subjects using functional magnetic resonance imaging. RESULTS All subjects showed a pronounced activation mainly involving the right inferior frontal gyrus and the right intraparietal sulcus. While the respective regions showed activation increases with improved performance after 2 weeks of training, the activation values decreased at the time of consolidation of performance gains after 4 weeks. CONCLUSIONS Our results suggest that training-related cerebral activation changes follow an inverse U-shaped quadratic function and raise the prospect of investigating cerebral mechanisms underlying training effects.

[1]  R. Coppola,et al.  Specific versus Nonspecific Brain Activity in a Parametric N-Back Task , 2000, NeuroImage.

[2]  Lothar R. Schad,et al.  Motor Dysfunction and Sensorimotor Cortex Activation Changes in Schizophrenia: A Study with Functional Magnetic Resonance Imaging , 1999, NeuroImage.

[3]  J C Gore,et al.  Preliminary evidence of improved verbal working memory performance and normalization of task-related frontal lobe activation in schizophrenia following cognitive exercises. , 2000, The American journal of psychiatry.

[4]  C. Chabris,et al.  Neural mechanisms of general fluid intelligence , 2003, Nature Neuroscience.

[5]  R. Desimone,et al.  Neural mechanisms for visual memory and their role in attention. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[6]  Karl J. Friston,et al.  Statistical parametric maps in functional imaging: A general linear approach , 1994 .

[7]  Hugh Garavan,et al.  Practice‐related functional activation changes in a working memory task , 2000, Microscopy research and technique.

[8]  Nick F. Ramsey,et al.  Functional Anatomical Correlates of Controlled and Automatic Processing , 2001, Journal of Cognitive Neuroscience.

[9]  J. Jonides,et al.  Storage and executive processes in the frontal lobes. , 1999, Science.

[10]  J. Duncan,et al.  Encoding Strategies Dissociate Prefrontal Activity from Working Memory Demand , 2003, Neuron.

[11]  M. Brammer,et al.  Effects on the brain of a psychological treatment: cognitive remediation therapy: functional magnetic resonance imaging in schizophrenia. , 2002, The British journal of psychiatry : the journal of mental science.

[12]  K J Friston,et al.  The predictive value of changes in effective connectivity for human learning. , 1999, Science.

[13]  R. Coppola,et al.  Physiological characteristics of capacity constraints in working memory as revealed by functional MRI. , 1999, Cerebral cortex.

[14]  Christoph Stippich,et al.  Impairment in basal limbic function in schizophrenia during affect recognition , 2003, Psychiatry Research: Neuroimaging.