Regulatory Dendritic Cells and Their Potential for Tolerance Induction

[1]  R. Lechler,et al.  Modified dendritic cells coexpressing self and allogeneic major histocompatability complex molecules: an efficient way to induce indirect pathway regulation. , 2004, Journal of the American Society of Nephrology : JASN.

[2]  J. Fung,et al.  Mechanistic Insights into Impaired Dendritic Cell Function by Rapamycin: Inhibition of Jak2/Stat4 Signaling Pathway1 , 2004, The Journal of Immunology.

[3]  H. Hauser,et al.  Hepatic dendritic cell subsets in the mouse , 2004, European journal of immunology.

[4]  Jun Guo,et al.  Cyclosporin A impairs dendritic cell migration by regulating chemokine receptor expression and inhibiting cyclooxygenase-2 expression. , 2004, Blood.

[5]  R. DeMatteo,et al.  Liver Dendritic Cells Are Less Immunogenic Than Spleen Dendritic Cells because of Differences in Subtype Composition1 , 2004, The Journal of Immunology.

[6]  A. Thomson,et al.  Dendritic cells: regulators of alloimmunity and opportunities for tolerance induction , 2003, Immunological reviews.

[7]  Michel C Nussenzweig,et al.  Tolerogenic dendritic cells. , 2003, Annual review of immunology.

[8]  Chunmei Wang,et al.  Blockade of CD40 pathway enhances the induction of immune tolerance by immature dendritic cells genetically modified to express cytotoxic T lymphocyte antigen 4 immunoglobulin , 2003, Transplantation.

[9]  W. Reith,et al.  The brain as an immune privileged site: dendritic cells of the central nervous system inhibit T cell activation , 2003, European journal of immunology.

[10]  A. Donnenberg,et al.  Dendritic cell subsets in blood and lymphoid tissue of rhesus monkeys and their mobilization with Flt3 ligand. , 2003, Blood.

[11]  M. Čolić,et al.  Mycophenolate mofetil inhibits differentiation, maturation and allostimulatory function of human monocyte‐derived dendritic cells , 2003, Clinical and experimental immunology.

[12]  T. Ichim,et al.  LF15‐0195 generates tolerogenic dendritic cells by suppression of NF‐κB signaling through inhibition of IKK activity , 2003, Journal of leukocyte biology.

[13]  B. Baban,et al.  Cutting Edge: Induced Indoleamine 2,3 Dioxygenase Expression in Dendritic Cell Subsets Suppresses T Cell Clonal Expansion1 , 2003, The Journal of Immunology.

[14]  Zhiliang Wang,et al.  Marked inhibition of transplant vascular sclerosis by in vivo-mobilized donor dendritic cells and anti-CD154 mAb1 , 2003, Transplantation.

[15]  A. Thomson,et al.  Influence of immunosuppressive drugs on dendritic cells. , 2003, Transplant immunology.

[16]  M. Claesson,et al.  Dendritic cells in peripheral tolerance and immunity , 2003, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[17]  A. Thomson,et al.  Rapamycin inhibits IL-4--induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo. , 2003, Blood.

[18]  A. Thomson,et al.  Pharmacologic, biologic, and genetic engineering approaches to potentiation of donorderived dendritic cell tolerogenicity1 , 2003, Transplantation.

[19]  Y. Lebranchu,et al.  Effects of immunosuppressive drugs on dendritic cells and tolerance induction , 2003, Transplantation.

[20]  T. Ichim,et al.  Synergistic tolerance induced by LF15-0195 and anti-CD45RB monoclonal antibody through suppressive dendritic cells1 , 2003, Transplantation.

[21]  A. Norment,et al.  Mucosal CD8α+ DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory properties , 2003, Immunology.

[22]  S. Ikehara,et al.  Heterogeneity of Dendritic Cells in the Mouse Liver: Identification and Characterization of Four Distinct Populations 1 , 2003, The Journal of Immunology.

[23]  Tomoki Ito,et al.  Immunomodulatory effects of cyclosporin A on human peripheral blood dendritic cell subsets , 2003, Immunology.

[24]  T. Ichim,et al.  Inhibitory Feedback Loop Between Tolerogenic Dendritic Cells and Regulatory T Cells in Transplant Tolerance 1 , 2003, The Journal of Immunology.

[25]  R. Kumar,et al.  Effects of 1α,25(OH)2D3 and its analogs on dendritic cell function , 2003 .

[26]  M. Uskoković,et al.  Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting allograft rejection and autoimmune diseases , 2003 .

[27]  A. Lau,et al.  Dendritic cells and immune regulation in the liver , 2003, Gut.

[28]  P. Allavena,et al.  Rapamycin impairs antigen uptake of human dendritic cells1 , 2003, Transplantation.

[29]  D. Rigal,et al.  Cyclosporin A inhibits dendritic cell maturation promoted by TNF‐α or LPS but not by double‐stranded RNA or CD40L , 2002, Journal of leukocyte biology.

[30]  A. Aruffo,et al.  Anti-CD40 therapy extends renal allograft survival in rhesus macaques1 , 2002, Transplantation.

[31]  Chendong Yang,et al.  Contrasting Impacts of Immunosuppressive Agents (Rapamycin, FK506, Cyclosporin A, and Dexamethasone) on Bidirectional Dendritic Cell-T Cell Interaction During Antigen Presentation1 , 2002, The Journal of Immunology.

[32]  A. Donnenberg,et al.  Strategies for preclinical evaluation of dendritic cell subsets for promotion of transplant tolerance in the nonhuman primate. , 2002, Human immunology.

[33]  P. Robbins,et al.  Marked Prolongation of Cardiac Allograft Survival by Dendritic Cells Genetically Engineered with NF-κB Oligodeoxyribonucleotide Decoys and Adenoviral Vectors Encoding CTLA4-Ig1 , 2002, The Journal of Immunology.

[34]  A. Thomson,et al.  Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells. , 2002, Blood.

[35]  A. Thomson,et al.  Genetic Engineering of Dendritic Cells to Enhance Their Tolerogenic Potential , 2002 .

[36]  P. Morel,et al.  Regulatory Th2 response induced following adoptive transfer of dendritic cells in prediabetic NOD mice , 2002, European journal of immunology.

[37]  C. Usal,et al.  Role for Thymic and Splenic Regulatory CD4+ T Cells Induced by Donor Dendritic Cells in Allograft Tolerance by LF15-0195 Treatment1 , 2002, The Journal of Immunology.

[38]  M. V. von Herrath,et al.  CD40L blockade prevents autoimmune diabetes by induction of bitypic NK/DC regulatory cells. , 2002, Immunity.

[39]  A. Thomson,et al.  MANIPULATION OF DENDRITIC CELLS FOR TOLERANCE INDUCTION IN TRANSPLANTATION AND AUTOIMMUNE DISEASE1 , 2002, Transplantation.

[40]  S. Specht,et al.  Immature and Mature CD8α+ Dendritic Cells Prolong the Survival of Vascularized Heart Allografts1 , 2002, The Journal of Immunology.

[41]  P Björck,et al.  Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice. , 2001, Blood.

[42]  J. Fung,et al.  Costimulation blockade promotes the apoptotic death of graft-infiltrating T cells and prolongs survival of hepatic allografts from FLT3L-treated donors. , 2001, Transplantation.

[43]  A. Thomson,et al.  Potential of tolerogenic dendritic cells for transplantation. , 2001, Seminars in immunology.

[44]  L. Adorini,et al.  Regulatory T Cells Induced by 1α,25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance1 , 2001, The Journal of Immunology.

[45]  A. Thomson,et al.  Designer dendritic cells for tolerance induction: guided not misguided missiles. , 2001, Trends in immunology.

[46]  D. Umetsu,et al.  Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen , 2001, Nature Immunology.

[47]  J. D. de Fijter,et al.  Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages. , 2001, Blood.

[48]  A. Gingras,et al.  The target of rapamycin (TOR) proteins , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[49]  J. Mulé,et al.  Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis. , 2001, The Journal of clinical investigation.

[50]  D. Kioussis,et al.  Glucocorticoids Attenuate T Cell Receptor Signaling , 2001, The Journal of experimental medicine.

[51]  S. Ghivizzani,et al.  Effective Treatment of Established Murine Collagen-Induced Arthritis by Systemic Administration of Dendritic Cells Genetically Modified to Express IL-41 , 2001, The Journal of Immunology.

[52]  H. Drexhage,et al.  Opposing effects of dehydroepiandrosterone and dexamethasone on the generation of monocyte-derived dendritic cells. , 2000, European journal of endocrinology.

[53]  T. Luger,et al.  Mycophenolate Mofetil Impairs the Maturation and Function of Murine Dendritic Cells1 , 2000, The Journal of Immunology.

[54]  A. Thomson,et al.  Phenotypic and Functional Characterization of Mouse Hepatic CD8α+ Lymphoid-Related Dendritic Cells1 , 2000, The Journal of Immunology.

[55]  M. Roncarolo,et al.  T-regulatory 1 cells: a novel subset of CD4 T cells with immunoregulatory properties. , 2000, The Journal of allergy and clinical immunology.

[56]  G. Schuler,et al.  Immature dendritic cells generated with low doses of GM‐CSF in the absence of IL‐4 are maturation resistant and prolong allograft survival in vivo , 2000, European journal of immunology.

[57]  J. Gauldie,et al.  Synergy in induction of increased renal allograft survival after portal vein infusion of dendritic cells transduced to express TGFbeta and IL-10, along with administration of CHO cells expressing the regulatory molecule OX-2. , 2000, Clinical immunology.

[58]  R. Offringa,et al.  Glucocorticoids transform CD40-triggering of dendritic cells into an alternative activation pathway resulting in antigen-presenting cells that secrete IL-10. , 2000, Blood.

[59]  H. Tagami,et al.  Dexamethasone and Cyclosporin A Affect the Maturation of Monocyte-Derived Dendritic Cells Differently , 2000, International Archives of Allergy and Immunology.

[60]  M. Daha,et al.  The effect of calcineurin inhibitors and corticosteroids on the differentiation of human dendritic cells , 2000 .

[61]  P. Ricciardi-Castagnoli,et al.  Differential effects of corticosteroids during different stages of dendritic cell maturation , 2000, European journal of immunology.

[62]  L. Adorini,et al.  1α,25-Dihydroxyvitamin D3 Inhibits Differentiation, Maturation, Activation, and Survival of Dendritic Cells Leading to Impaired Alloreactive T Cell Activation , 2000, The Journal of Immunology.

[63]  F. Huang,et al.  A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes , 2000, The Journal of experimental medicine.

[64]  A. Thomson,et al.  Effects of Liver-Derived Dendritic Cell Progenitors on Th1- and Th2-Like Cytokine Responses In Vitro and In Vivo1 , 2000, The Journal of Immunology.

[65]  A. Thomson,et al.  Transduction of dendritic cell progenitors with a retroviral vector encoding viral interleukin-10 and enhanced green fluorescent protein allows purification of potentially tolerogenic antigen-presenting cells. , 1999, Transplantation.

[66]  R. Pierson,et al.  Prolongation of primate cardiac allograft survival by treatment with ANTI-CD40 ligand (CD154) antibody. , 1999, Transplantation.

[67]  W. Cook,et al.  Peritransplant tolerance induction in macaques: early events reflecting the unique synergy between immunotoxin and deoxyspergualin. , 1999, Transplantation.

[68]  Koichiro Nakamura,et al.  Differential effects of cytokines and immunosuppressive drugs on CD40, B7-1, and B7-2 expression on purified epidermal Langerhans cells1. , 1999, The Journal of investigative dermatology.

[69]  L. Lu,et al.  Cyclosporine A inhibits the expression of costimulatory molecules on in vitro-generated dendritic cells: association with reduced nuclear translocation of nuclear factor kappa B. , 1999, Transplantation.

[70]  A. Gambotto,et al.  Genetic engineering of dendritic cells to express immunosuppressive molecules (viral IL‐10, TGF‐β, and CTLA4Ig) , 1999, Journal of leukocyte biology.

[71]  P. Kalinski,et al.  Corticosteroids inhibit the production of inflammatory mediators in immature monocyte‐derived DC and induce the development of tolerogenic DC3 , 1999, Journal of leukocyte biology.

[72]  A. Iwasaki,et al.  Freshly Isolated Peyer's Patch, but Not Spleen, Dendritic Cells Produce Interleukin 10 and Induce the Differentiation of T Helper Type 2 Cells , 1999, The Journal of experimental medicine.

[73]  D. Harlan,et al.  Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[74]  P. Allavena,et al.  Glucocorticoids affect human dendritic cell differentiation and maturation. , 1999, Journal of immunology.

[75]  V. Verhasselt,et al.  Inhibition of human dendritic cell functions by methylprednisolone. , 1999, Transplantation.

[76]  I. Kimber,et al.  Inhibition by dexamethasone of Langerhans cell migration: influence of epidermal cytokine signals. , 1999, Immunopharmacology.

[77]  P. Holt,et al.  Resting Respiratory Tract Dendritic Cells Preferentially Stimulate T Helper Cell Type 2 (Th2) Responses and Require Obligatory Cytokine Signals for Induction of  Th1 Immunity , 1998, The Journal of experimental medicine.

[78]  P. Kalinski,et al.  Glucocorticoids inhibit bioactive IL-12p70 production by in vitro-generated human dendritic cells without affecting their T cell stimulatory potential. , 1998, Journal of immunology.

[79]  K. Wake,et al.  Maturation of rat dendritic cells during intrahepatic translocation evaluated using monoclonal antibodies and electron microscopy , 1998, Cell and Tissue Research.

[80]  R. Thieroff-Ekerdt,et al.  Inhibitory effect of 1α,25-dihydroxyvitamin D3 on allogeneic lymphocyte stimulation and Langerhans cell maturation , 1998, Archives of Dermatological Research.

[81]  L. Lu,et al.  Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival. , 1997, Transplantation.

[82]  M. Sayegh,et al.  CD28-B7 T cell costimulatory blockade by CTLA4Ig in the rat renal allograft model: inhibition of cell-mediated and humoral immune responses in vivo. , 1996, Transplantation.

[83]  Freddie H. Fu,et al.  Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80dim, CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipients. , 1996, Transplantation.

[84]  N. Van Houten,et al.  Direct measurement of anergy of antigen-specific T cells following oral tolerance induction. , 1996, Journal of immunology.

[85]  V. Perry,et al.  The potential role of dendritic cells in immune-mediated inflammatory diseases in the central nervous system , 1996, Neuroscience.

[86]  Mark A. Murcko,et al.  Structure and Mechanism of Inosine Monophosphate Dehydrogenase in Complex with the Immunosuppressant Mycophenolic Acid , 1996, Cell.

[87]  H. Weiner,et al.  Dose‐dependent Activation and Deletion of Antigen‐specific T Cells following Oral Tolerance , 1996, Annals of the New York Academy of Sciences.

[88]  T. Starzl,et al.  Granulocyte/macrophage colony-stimulating factor-stimulated hepatic dendritic cell progenitors prolong pancreatic islet allograft survival. , 1995, Transplantation.

[89]  M. Moser,et al.  Glucocorticoids down‐regulate dendritic cell function in vitro and in vivo , 1995, European journal of immunology.

[90]  L. Rodella,et al.  Effects of cyclosporin A on some accessory cells of rat thymus. , 1995, International journal of experimental pathology.

[91]  J. Damoiseaux,et al.  The effects of In vivo cyclosporin A administration on rat thymic dendritic cells , 1994, Clinical and experimental immunology.

[92]  P. Linsley,et al.  Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion , 1993, The Journal of experimental medicine.

[93]  Li Wu,et al.  The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells , 1992, The Journal of experimental medicine.

[94]  J. Bos,et al.  Inhibitory effect of cyclosporin A on antigen and alloantigen presenting capacity of human epidermal Langerhans cells , 1991, The British journal of dermatology.

[95]  L. Dubertret,et al.  Cyclosporin A inhibits the antigen-presenting functions of freshly isolated human Langerhans cells in vitro. , 1991, The Journal of investigative dermatology.

[96]  S. Knight,et al.  LOW‐DOSE IMMUNOSUPPRESSION BY CYCLOSPORINE OPERATING VIA ANTIGEN‐PRESENTING DENDRITIC CELLS , 1990, Transplantation.

[97]  A. Pollard,et al.  Characterization of murine lung dendritic cells: similarities to Langerhans cells and thymic dendritic cells , 1990, The Journal of experimental medicine.

[98]  M. Furue,et al.  Direct effects of glucocorticosteroids on epidermal Langerhans cells. , 1989, The Journal of investigative dermatology.

[99]  M. Roberts,et al.  BLOCKING OF ACQUISITION AND PRESENTATION OF ANTIGEN BY DENDRITIC CELLS WITH CYCLOSPORINE , 1988, Transplantation.

[100]  M. Furue,et al.  The effect of cyclosporine on epidermal cells. I. Cyclosporine inhibits accessory cell functions of epidermal Langerhans cells in vitro. , 1988, Journal of immunology.

[101]  S. Breathnach,et al.  Effects of topical corticosteroid therapy on Langerhans cell antigen presenting function in human skin , 1988, The British journal of dermatology.

[102]  H. Umezawa,et al.  Prolongation of rat heart allograft survival by 15-deoxyspergualin. , 1987 .

[103]  F. Abe,et al.  Suppression of tissue graft rejection by spergualin. , 1985, Journal of antibiotics (Tokyo. 1968).

[104]  H. Naganawa,et al.  A new antitumor antibiotic, spergualin: isolation and antitumor activity. , 1981, The Journal of antibiotics.

[105]  A. Thomson,et al.  Dendritic cells: emerging pharmacological targets of immunosuppressive drugs , 2004, Nature Reviews Immunology.

[106]  Simon C Watkins,et al.  Dendritic cells transduced to express interleukin-4 prevent diabetes in nonobese diabetic mice with advanced insulitis. , 2003, Human gene therapy.

[107]  P. Romagnoli,et al.  Inhibited differentiation of Langerhans cells in the rat epidermis upon systemic treatment with cyclosporin A. , 2001, Histology and histopathology.

[108]  M. Metcalfe,et al.  Rapamycin in transplantation: a review of the evidence. , 2001, Kidney international.

[109]  H. Tahara,et al.  Feasibility of CTLA4Ig gene delivery and expression in vivo using retrovirally transduced myeloid dendritic cells that induce alloantigen-specific T cell anergy in vitro , 2000, Gene Therapy.

[110]  P. Holt,et al.  Characterization of dendritic cell populations in the respiratory tract. , 2000, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[111]  T. Koyanagi,et al.  Abortive alloantigen presentation by donor dendritic cells leads to donor-specific tolerance: a study with a preoperative CTLA4Ig inoculation , 2000, Urological Research.

[112]  T. Macdonald Effector and regulatory lymphoid cells and cytokines in mucosal sites. , 1999, Current topics in microbiology and immunology.