The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines

[1]  M. Braddock,et al.  Interleukin-18: a pro-inflammatory cytokine that plays an important role in acute pancreatitis , 2007, Expert opinion on therapeutic targets.

[2]  H. Möller,et al.  The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine , 2006, Molecular Psychiatry.

[3]  T. Dinan,et al.  Antidepressant therapy and C-reactive protein levels , 2006, British Journal of Psychiatry.

[4]  C. Caltagirone,et al.  Response of emotional unawareness after stroke to antidepressant treatment. , 2006, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[5]  A. Gottlieb,et al.  Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial , 2006, The Lancet.

[6]  Andrew H. Miller,et al.  Cytokines sing the blues: inflammation and the pathogenesis of depression. , 2006, Trends in immunology.

[7]  N. Rothwell,et al.  A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[8]  P. Stahel,et al.  IL-18: a key player in neuroinflammation and neurodegeneration? , 2005, Trends in Neurosciences.

[9]  N. Rothwell,et al.  Interleukin-1 and neuronal injury , 2005, Nature Reviews Immunology.

[10]  M. Wichers,et al.  Cytokines and major depression , 2005, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[11]  R. Teasell,et al.  Lesion Location and Poststroke Depression: Systematic Review of the Methodological Limitations in the Literature , 2004, Stroke.

[12]  S. Yim,et al.  Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the interleukin-1 receptor antagonist and tumor necrosis factor-α genes, but not the interleukin-1β gene , 2004, Neuroscience Letters.

[13]  N. Rothwell,et al.  Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome , 2004, BMC neurology.

[14]  H. Link,et al.  Matrix Metalloproteinase and Cytokine Profiles in Monocytes over the Course of Stroke , 2001, Journal of Clinical Immunology.

[15]  P. Tonali,et al.  Tumor necrosis factor alpha serum levels and inflammatory response in acute ischemic stroke patients , 2004, Neurological Sciences.

[16]  M. Maes,et al.  In humans, corticotropin releasing hormone antagonizes some of the negative immunoregulatory effects of serotonin. , 2003, Neuro endocrinology letters.

[17]  S. Blankenberg,et al.  Interleukin-18 and the Risk of Coronary Heart Disease in European Men: The Prospective Epidemiological Study of Myocardial Infarction (PRIME) , 2003, Circulation.

[18]  P. Musiani,et al.  IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[19]  N. Rothwell,et al.  Delayed administration of interleukin‐1 receptor antagonist protects against transient cerebral ischaemia in the rat , 2003, British journal of pharmacology.

[20]  J. Losy,et al.  Interleukin-18 in acute ischaemic stroke patients , 2003, Neurological Sciences.

[21]  À. Rovira,et al.  C-Reactive Protein Predicts Further Ischemic Events in First-Ever Transient Ischemic Attack or Stroke Patients With Intracranial Large-Artery Occlusive Disease , 2003, Stroke.

[22]  A. Grau,et al.  Inflammation and Infections as Risk Factors for Ischemic Stroke , 2003, Stroke.

[23]  L. Ferrucci,et al.  Inflammatory markers and depressed mood in older persons: results from the health, aging and body composition study , 2003, Biological Psychiatry.

[24]  O. Çalıyurt,et al.  Increased serum tumor necrosis factor-alpha levels and treatment response in major depressive disorder , 2003, Psychopharmacology.

[25]  A. Grau,et al.  Multiple Levels of Regulation of the Interleukin-6 System in Stroke , 2003, Stroke.

[26]  J. Um,et al.  Interleukin-1 gene cluster polymorphisms in cerebral infarction. , 2003, Cytokine.

[27]  N. Rothwell Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential , 2003, Brain, Behavior, and Immunity.

[28]  N. Rothwell,et al.  An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis , 2003, Journal of Neuroimmunology.

[29]  N. Rothwell,et al.  Interleukin‐18 induces expression and release of cytokines from murine glial cells: interactions with interleukin‐1β , 2003, Journal of neurochemistry.

[30]  N. Rothwell,et al.  No Role for Interleukin-18 in Acute Murine Stroke-Induced Brain Injury , 2003, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[31]  RobertoPola,et al.  Synergistic Effect of −174 G/C Polymorphism of the Interleukin-6 Gene Promoter and 469 E/K Polymorphism of the Intercellular Adhesion Molecule-1 Gene in Italian Patients With History of Ischemic Stroke , 2003 .

[32]  M. Margaglione,et al.  Relevance of Interleukin-1 Receptor Antagonist Intron-2 Polymorphism in Ischemic Stroke , 2003, Cerebrovascular Diseases.

[33]  R. Flore,et al.  Synergistic Effect of −174 G/C Polymorphism of the Interleukin-6 Gene Promoter and 469 E/K Polymorphism of the Intercellular Adhesion Molecule-1 Gene in Italian Patients With History of Ischemic Stroke , 2003, Stroke.

[34]  Á. Chamorro,et al.  Levels of Anti-Inflammatory Cytokines and Neurological Worsening in Acute Ischemic Stroke , 2003, Stroke.

[35]  A. Hofman,et al.  Inflammatory proteins and depression in the elderly. , 2003, Epidemiology.

[36]  M. Wichers,et al.  The psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans. , 2002, The international journal of neuropsychopharmacology.

[37]  C. Caltagirone,et al.  Predictors of cognitive level and depression severity are different in patients with left and right hemispheric stroke within the first year of illness , 2002, Journal of Neurology.

[38]  N. Castanon,et al.  Effects of antidepressants on cytokine production and actions , 2002, Brain, Behavior, and Immunity.

[39]  H. Anisman,et al.  Further evidence for the depressive effects of cytokines: Anhedonia and neurochemical changes , 2002, Brain, Behavior, and Immunity.

[40]  C. Dinarello,et al.  The IL-1 family and inflammatory diseases. , 2002, Clinical and experimental rheumatology.

[41]  S. Gangemi,et al.  Interleukin-18 and CD30 serum levels in patients with moderate-severe depression. , 2002, Mediators of inflammation.

[42]  K. Blomgren,et al.  Interleukin-18 Involvement in Hypoxic–Ischemic Brain Injury , 2002, The Journal of Neuroscience.

[43]  Á. Chamorro,et al.  A -174G/C polymorphism of the interleukin-6 gene in patients with lacunar infarction , 2002, Neuroscience Letters.

[44]  H. Okamura,et al.  Plasma Interleukin-18 Levels in Patients With Psychiatric Disorders , 2002, Journal of immunotherapy.

[45]  H. Bojar,et al.  Interleukin-12 and interleukin-18 induce indoleamine 2,3-dioxygenase (IDO) activity in human osteosarcoma cell lines independently from interferon-gamma. , 2002, Anticancer research.

[46]  N. Rothwell,et al.  Site-specific actions of interleukin-1 on excitotoxic cell death in the rat striatum , 2002, Brain Research.

[47]  G. Stoll,et al.  Interleukin-18 Expression after Focal Ischemia of the Rat Brain: Association with the Late-Stage Inflammatory Response , 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[48]  R. Dantzer,et al.  Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy , 2002, Molecular Psychiatry.

[49]  M. Maes,et al.  Immunotherapy with interferon-alpha in patients affected by chronic hepatitis C induces an intercorrelated stimulation of the cytokine network and an increase in depressive and anxiety symptoms , 2001, Psychiatry Research.

[50]  L. Joosten,et al.  Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis. , 2001, The Journal of clinical investigation.

[51]  H. Becher,et al.  Monocyte function and plasma levels of interleukin-8 in acute ischemic stroke , 2001, Journal of the Neurological Sciences.

[52]  J. Losy,et al.  Early TNF‐α levels correlate with ischaemic stroke severity , 2001 .

[53]  R. Dantzer,et al.  Association between immune activation and early depressive symptoms in cancer patients treated with interleukin-2-based therapy , 2001, Psychoneuroendocrinology.

[54]  A. Grau,et al.  Increased cytokine release by leucocytes in survivors of stroke at young age , 2001, European journal of clinical investigation.

[55]  C. Caltagirone,et al.  Alexithymic Features in Stroke: Effects of Laterality and Gender , 2001, Psychosomatic medicine.

[56]  A. Tedgui,et al.  Expression of Interleukin-18 in Human Atherosclerotic Plaques and Relation to Plaque Instability , 2001, Circulation.

[57]  M. Kaste,et al.  Magnetic resonance imaging correlates of depression after ischemic stroke. , 2001, Archives of general psychiatry.

[58]  M. Seishima,et al.  Lipopolysaccharide induction of indoleamine 2,3‐dioxygenase is mediated dominantly by an IFN‐γ‐independent mechanism , 2001, European journal of immunology.

[59]  E. Galloni,et al.  Temporal profile of serum anti-inflammatory and pro-inflammatory interleukins in acute ischemic stroke patients , 2001, Neurological Sciences.

[60]  M. Di Napoli,et al.  C-Reactive Protein in Ischemic Stroke: An Independent Prognostic Factor , 2001, Stroke.

[61]  A K Manatunga,et al.  Paroxetine for the prevention of depression induced by high-dose interferon alfa. , 2001, The New England journal of medicine.

[62]  AllanHouse,et al.  Mortality at 12 and 24 Months After Stroke May Be Associated With Depressive Symptoms at 1 Month , 2001 .

[63]  A. Young,et al.  Raised levels of plasma interleukin‐1β in major and postviral depression , 2001, Acta psychiatrica Scandinavica.

[64]  R. Dantzer Cytokine-Induced Sickness Behavior: Where Do We Stand? , 2001, Brain, Behavior, and Immunity.

[65]  J. Losy,et al.  Early TNF-alpha levels correlate with ischaemic stroke severity. , 2001, Acta neurologica Scandinavica.

[66]  Á. Chamorro,et al.  Proinflammatory Cytokines and Early Neurological Worsening in Ischemic Stroke , 2000, Stroke.

[67]  C. Dinarello Interleukin-18, a proinflammatory cytokine. , 2000, European cytokine network.

[68]  T. Babcock,et al.  Transcriptional activation of indoleamine dioxygenase by interleukin 1 and tumor necrosis factor alpha in interferon-treated epithelial cells. , 2000, Cytokine.

[69]  R. Dantzer,et al.  Early depressive symptoms in cancer patients receiving interleukin 2 and/or interferon alfa-2b therapy. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[70]  E. Bosmans,et al.  Plasma levels of interleukin-6, interleukin-10, and interleukin-1 receptor antagonist in depression: comparison between the acute state and after remission. , 2000, Polish journal of pharmacology.

[71]  H. Anisman,et al.  Interleukin-1β production in dysthymia before and after pharmacotherapy , 1999, Biological Psychiatry.

[72]  J. Levine,et al.  Cerebrospinal Cytokine Levels in Patients with Acute Depression , 1999, Neuropsychobiology.

[73]  P. Kivisäkk,et al.  Increased IL-1beta, IL-8, and IL-17 mRNA expression in blood mononuclear cells observed in a prospective ischemic stroke study. , 1999, Stroke.

[74]  F. Sarinella,et al.  Increased Cytokine Release from Peripheral Blood Cells after Acute Stroke , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[75]  F. Barone,et al.  Inflammatory Mediators and Stroke: New Opportunities for Novel Therapeutics , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[76]  M. Wong,et al.  The role of inflammatory mediators in the biology of major depression: central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection , 1999, Molecular Psychiatry.

[77]  K. Lees,et al.  C-reactive protein and outcome after ischemic stroke. , 1999, Stroke.

[78]  T. Joh,et al.  Cultures of astrocytes and microglia express interleukin 18. , 1999, Brain research. Molecular brain research.

[79]  H. Anisman,et al.  Interleukin-1 beta production in dysthymia before and after pharmacotherapy. , 1999, Biological psychiatry.

[80]  A. Turnbull,et al.  Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action. , 1999, Physiological reviews.

[81]  N. Rothwell,et al.  Cloning of rat brain interleukin-18 cDNA , 1998, Molecular Psychiatry.

[82]  P. Kivisäkk,et al.  Ischemic stroke is associated with a systemic increase of blood mononuclear cells expressing interleukin-8 mRNA. , 1998, Stroke.

[83]  S. Ekholm,et al.  Intrathecal release of pro‐ and anti‐inflammatory cytokines during stroke , 1997, Clinical and experimental immunology.

[84]  B. Brew,et al.  Quinolinic Acid Production by Macrophages Stimulated with IFN-γ, TNF-α, and IFN-α , 1997 .

[85]  N. Rothwell,et al.  Cytokines and acute neurodegeneration , 1997, Molecular Psychiatry.

[86]  B. Brew,et al.  Quinolinic acid production by macrophages stimulated with IFN-gamma, TNF-alpha, and IFN-alpha. , 1997, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[87]  Y. Kim,et al.  Serial measurement of interleukin-6, transforming growth factor-beta, and S-100 protein in patients with acute stroke. , 1996, Stroke.

[88]  J. Krupiński,et al.  Increased Expression of TGF-β1 in Brain Tissue After Ischemic Stroke in Humans , 1996 .

[89]  J. Krupiński,et al.  Increased expression of TGF-beta 1 in brain tissue after ischemic stroke in humans. , 1996, Stroke.

[90]  R G Robinson,et al.  Lesion location and poststroke depression. , 1996, The Journal of neuropsychiatry and clinical neurosciences.

[91]  E. Bosmans,et al.  Increased serum interleukin-1-receptor-antagonist concentrations in major depression. , 1995, Journal of affective disorders.

[92]  ChristianBlomstrand,et al.  Early Intrathecal Production of Interleukin-6 Predicts the Size of Brain Lesion in Stroke , 1995 .

[93]  B. Hu,et al.  Interleukin-1 enhances indoleamine 2,3-dioxygenase activity by increasing specific mRNA expression in human mononuclear phagocytes. , 1995, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[94]  B. Coull,et al.  Interleukin‐6 and interleukin‐1 receptor antagonist in acute stroke , 1995, Annals of neurology.

[95]  V. Arolt,et al.  Cytokine Production and Serum Proteins in Depression , 1995, Scandinavian journal of immunology.

[96]  R. Dantzer,et al.  Synergy between tumor necrosis factor α and interleukin-1 in the induction of sickness behavior in mice , 1994, Psychoneuroendocrinology.

[97]  R. Robinson,et al.  Longitudinal Assessment of Depression and Cognitive Impairment Following Stroke , 1994, The Journal of nervous and mental disease.

[98]  H. Meltzer,et al.  Interleukin-1 beta: a putative mediator of HPA axis hyperactivity in major depression? , 1993, The American journal of psychiatry.

[99]  K. Asplund,et al.  Major Depression in Stroke Patients: A 3‐Year Longitudinal Study , 1993, Stroke.

[100]  C. Wallesch,et al.  Depression in acute and chronic aphasia: symptoms, pathoanatomical-clinical correlations and functional implications. , 1993, Journal of neurology, neurosurgery, and psychiatry.

[101]  R. Robinson,et al.  Association of depression with 10-year poststroke mortality. , 1993, The American journal of psychiatry.

[102]  C. Wallesch,et al.  Depressive changes in stroke patients. , 1993, Disability and rehabilitation.

[103]  R. Robinson,et al.  Reduction of CSF monoamine metabolites in poststroke depression: a preliminary report. , 1992, The Journal of neuropsychiatry and clinical neurosciences.

[104]  R G Robinson,et al.  The impact of poststroke depression on recovery in activities of daily living over a 2-year follow-up. , 1990, Archives of neurology.

[105]  R. Robinson,et al.  Lateralization of dementia of depression in stroke patients. , 1989, The American journal of psychiatry.

[106]  H. Mayberg,et al.  PET imaging of cortical S2 serotonin receptors after stroke: lateralized changes and relationship to depression. , 1988, The American journal of psychiatry.

[107]  R. Robinson,et al.  Post-stroke depression and lesion location. , 1988, Stroke.

[108]  R G Robinson,et al.  Comparison of cortical and subcortical lesions in the production of poststroke mood disorders. , 1987, Brain : a journal of neurology.

[109]  R. Robinson,et al.  Mood change following left hemispheric brain injury , 1981, Annals of neurology.

[110]  D. Reis,et al.  Reversible changes in the activities and amounts of tyrosine hydroxylase in dopamine neurons of the substantia nigra in response to axonal injury as studied by immunochemical and immunocytochemical methods , 1978, Brain Research.

[111]  F. Bloom,et al.  Pharmacological treatment following experimental cerebral infarction: implications for understanding psychological symptoms of human stroke. , 1977, Biological psychiatry.

[112]  Saul H. Fisher Psychiatric considerations of cerebral vascular disease. , 1961, The American journal of cardiology.

[113]  A. Meyer THE ANATOMICAL FACTS AND CLINICAL VARIETIES OF TRAUMATIC INSANITY , 1904 .