Functional magnetic resonance imaging detection of vascular reactivity in cerebral amyloid angiopathy

In addition to its role in hemorrhagic stroke, advanced cerebral amyloid angiopathy (CAA) is also associated with ischemic lesions and vascular cognitive impairment. We used functional magnetic resonance imaging (MRI) techniques to identify CAA‐associated vascular dysfunction.

[1]  H. Vinters,et al.  Cerebral amyloid angiopathy: incidence and complications in the aging brain. II. The distribution of amyloid vascular changes. , 1983, Stroke.

[2]  Steven Warach,et al.  Cerebral Microbleeds : A Field Guide to their Detection and Interpretation , 2012 .

[3]  J. Growdon,et al.  Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy. , 2006, Neurology.

[4]  George A. Carlson,et al.  Exogenous Aβ1–40 Reproduces Cerebrovascular Alterations Resulting from Amyloid Precursor Protein Overexpression in Mice , 2000, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[5]  David H. Salat,et al.  Age-associated reductions in cerebral blood flow are independent from regional atrophy , 2011, NeuroImage.

[6]  H. Vinters,et al.  Cerebral Microinfarcts Associated with Severe Cerebral β‐Amyloid Angiopathy , 2010, Brain pathology.

[7]  R. Passingham The hippocampus as a cognitive map J. O'Keefe & L. Nadel, Oxford University Press, Oxford (1978). 570 pp., £25.00 , 1979, Neuroscience.

[8]  Eric E. Smith,et al.  White Matter Alterations in Cerebral Amyloid Angiopathy Measured by Diffusion Tensor Imaging , 2006, Stroke.

[9]  M. Menéndez-González,et al.  Vasomotor Reactivity Is Similarly Impaired in Patients with Alzheimer's Disease and Patients with Amyloid Hemorrhage , 2011, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[10]  Douglas C. Noll,et al.  Vascular dynamics and BOLD fMRI: CBF level effects and analysis considerations , 2006, NeuroImage.

[11]  Hidekazu Tomimoto,et al.  SILENT ISCHEMIC INFARCTS ARE ASSOCIATED WITH HEMORRHAGE BURDEN IN CEREBRAL AMYLOID ANGIOPATHY , 2010, Neurology.

[12]  Ravi S. Menon,et al.  Neuroimaging Demonstration of Evolving Small Vessel Ischemic Injury in Cerebral Amyloid Angiopathy , 2009, Stroke.

[13]  S. Leurgans,et al.  Cerebral amyloid angiopathy pathology and cognitive domains in older persons , 2011, Annals of neurology.

[14]  Keith A. Johnson,et al.  Imaging of amyloid burden and distribution in cerebral amyloid angiopathy , 2007, Annals of neurology.

[15]  Bruce Fischl,et al.  Accurate and robust brain image alignment using boundary-based registration , 2009, NeuroImage.

[16]  André J. W. van der Kouwe,et al.  Brain morphometry with multiecho MPRAGE , 2008, NeuroImage.

[17]  Phillip B. Jones,et al.  Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy. , 2007, Brain : a journal of neurology.

[18]  G. Glover,et al.  Neuroimaging at 1.5 T and 3.0 T: Comparison of oxygenation‐sensitive magnetic resonance imaging , 2001, Magnetic resonance in medicine.

[19]  C. Rowe,et al.  11C-PIB binding is increased in patients with cerebral amyloid angiopathy–related hemorrhage , 2010, Neurology.

[20]  Eric E. Smith,et al.  Plasma β-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy , 2006, Neurology.

[21]  R. Campbell,et al.  Clinicopathologic studies of primary cerebral amyloid angiopathy. , 1979, Mayo Clinic proceedings.

[22]  J. Baron,et al.  Acute ischaemic brain lesions in intracerebral haemorrhage: multicentre cross-sectional magnetic resonance imaging study. , 2011, Brain : a journal of neurology.

[23]  Eric E. Smith,et al.  Impaired visual evoked flow velocity response in cerebral amyloid angiopathy , 2008, Neurology.

[24]  E. Englund,et al.  Cerebral Amyloid Angiopathy, White Matter Lesions and Alzheimer Encephalopathy – A Histopathological Assessment , 2002, Dementia and Geriatric Cognitive Disorders.

[25]  K. Furie,et al.  Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage. , 2000, The New England journal of medicine.

[26]  David M Holtzman,et al.  Cerebrovascular Dysfunction in Amyloid Precursor Protein Transgenic Mice: Contribution of Soluble and Insoluble Amyloid-β Peptide, Partial Restoration via γ-Secretase Inhibition , 2008, The Journal of Neuroscience.

[27]  M. D’Esposito,et al.  Alterations in the BOLD fMRI signal with ageing and disease: a challenge for neuroimaging , 2003, Nature Reviews Neuroscience.

[28]  C. Iadecola,et al.  Aβ-Induced Vascular Oxidative Stress and Attenuation of Functional Hyperemia in Mouse Somatosensory Cortex , 2004, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[29]  S. Greenberg,et al.  Clinical diagnosis of cerebral amyloid angiopathy: Validation of the Boston Criteria , 2003, Current atherosclerosis reports.

[30]  Eric E. Smith,et al.  Clinical diagnosis of cerebral amyloid angiopathy: Validation of the Boston Criteria , 2003, Current atherosclerosis reports.