Enantioselectivity of bunitrolol 4-hydroxylation is reversed by the change of an amino acid residue from valine to methionine at position 374 of cytochrome P450-2D6.
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T. Ishikawa | S. Narimatsu | N. Shimada | S. Ohmori | Y. Yabusaki | T. Horie | M. Kitada | R. Kato | S. Ono | M. Tsutsui | T. Ichioka