Quantitative-trait locus for specific language and reading deficits on chromosome 6p.

Reading disability (RD), or dyslexia, is a complex cognitive disorder manifested by difficulties in learning to read, in otherwise normal individuals. Individuals with RD manifest deficits in several reading and language skills. Previous research has suggested the existence of a quantitative-trait locus (QTL) for RD on the short arm of chromosome 6. In the present study, RD subjects' performance in several measures of word recognition and component skills of orthographic coding, phonological decoding, and phoneme awareness were individually subjected to QTL analysis, with a new sample of 126 sib pairs, by means of a multipoint mapping method and eight informative DNA markers on chromosome 6 (D6S461, D6S276, D6S105, D6S306, D6S258, D6S439, D6S291, and D6S1019). The results indicate significant linkage across a distance of at least 5 cM for deficits in orthographic (LOD = 3.10) and phonological (LOD = 2.42) skills, confirming previous findings.

[1]  R M Idury,et al.  A simple method for automated allele binning in microsatellite markers. , 1997, Genome research.

[2]  M. Carrington,et al.  Heterogeneity in rates of recombination in the 6-Mb region telomeric to the human major histocompatibility complex. , 1997, Genomics.

[3]  S. Xu,et al.  Using the expectation or the distribution of the identity by descent for mapping quantitative trait loci under the random model. , 1996, American journal of human genetics.

[4]  D W Fulker,et al.  An improved multipoint sib-pair analysis of quantitative traits , 1996, Behavior genetics.

[5]  A. Roter,et al.  An approach to high-throughput genotyping. , 1996, Genome research.

[6]  M. Burt,et al.  A 4.5-megabase YAC contig and physical map over the hemochromatosis gene region. , 1996, Genomics.

[7]  E. Lander,et al.  Complete multipoint sib-pair analysis of qualitative and quantitative traits. , 1995, American journal of human genetics.

[8]  D W Fulker,et al.  Quantitative trait locus for reading disability: correction. , 1995, Science.

[9]  N Risch,et al.  Extreme discordant sib pairs for mapping quantitative trait loci in humans. , 1995, Science.

[10]  D. Share.  Phonological recoding and self-teaching: sine qua non of reading acquisition , 1995, Cognition.

[11]  L. Cardon,et al.  Multipoint interval mapping of quantitative trait loci, using sib pairs. , 1995, American journal of human genetics.

[12]  D W Fulker,et al.  Quantitative trait locus for reading disability on chromosome 6. , 1994, Science.

[13]  H. Lubs,et al.  Suggestive linkage of developmental dyslexia to chromosome 1p34-p36 , 1993, The Lancet.

[14]  M. Bruck.  Persistence of dyslexics' phonological awareness deficits. , 1992 .

[15]  M. Snowling,et al.  The Nonword Reading Deficit in Developmental Dyslexia: A Review. , 1992 .

[16]  B. Pennington,et al.  Screening for multiple genes influencing dyslexia , 1991 .

[17]  L. Cardon,et al.  Multiple regression analysis of sib-pair data on reading to detect quantitative trait loci , 1991 .

[18]  G. Carey,et al.  Linkage analysis of quantitative traits: increased power by using selected samples. , 1991, American journal of human genetics.

[19]  D. Fulker,et al.  Specific Deficits in Component Reading and Language Skills , 1989, Journal of learning disabilities.

[20]  K. Stanovich.  Explaining the Differences Between the Dyslexic and the Garden-Variety Poor Reader , 1988, Journal of learning disabilities.

[21]  D. Fulker,et al.  Multiple regression analysis of twin data: etiology of deviant scores versus individual differences. , 1988, Acta geneticae medicae et gemellologiae.

[22]  D. Fulker,et al.  Multiple regression analysis of twin data , 1985, Behavior genetics.

[23]  G. E. MacKinnon,et al.  Reading Research Advances in Theory and Practice , 1985 .

[24]  B. Pennington,et al.  Specific reading disability: identification of an inherited form through linkage analysis. , 1983, Science.

[25]  R. Elston,et al.  The investigation of linkage between a quantitative trait and a marker locus , 1972, Behavior genetics.

[26]  J. Lamb,et al.  A quantitative-trait locus on chromosome 6p influences different aspects of developmental dyslexia. , 1999, American journal of human genetics.

[27]  B. F. Pennington.  Using genetics to dissect cognition. , 1997, American journal of human genetics.

[28]  E L Grigorenko,et al.  Susceptibility loci for distinct components of developmental dyslexia on chromosomes 6 and 15. , 1997, American journal of human genetics.

[29]  E. Wijsman,et al.  Genetic analysis of simulated oligogenic traits in nuclear and extended pedigrees: Summary of GAW10 contributions , 1997, Genetic epidemiology.

[30]  J. Defries.  Colorado Learning Disabilities Research Center , 1997 .

[31]  G. Lyon,et al.  Toward a definition of dyslexia , 1995, Annals of dyslexia.

[32]  R. Olson,et al.  Computer-based phonological awareness and reading instruction , 1995, Annals of dyslexia.

[33]  Joseph K. Torgesen,et al.  Development of Reading-Related Phonological Processing Abilities: New Evidence of Bidirectional Causality from a Latent Variable Longitudinal Study. , 1994 .

[34]  Richard K. Olson,et al.  Genes, Environment, and the Development of Orthographic Skills , 1994 .

[35]  G. Reid Lyon,et al.  Frames of reference for the assessment of learning disabilities : new views on measurement issues , 1994 .

[36]  Richard K. Olson,et al.  Measurement of word recognition, orthographic, and phonological skills. , 1994 .

[37]  Maggie Bruck,et al.  Persistence of dyslexics' phonological deficits. , 1992 .

[38]  B. Pennington,et al.  Spelling errors and reading fluency in compensated adult dyslexics , 1991, Annals of dyslexia.