From Genome-Wide Association Study to Phenome-Wide Association Study: New Paradigms in Obesity Research.

[1]  J. Despres,et al.  Obesity and cardiovascular disease: friend or foe? , 2016, European heart journal.

[2]  F. Pociot,et al.  MicroRNAs as regulators of beta‐cell function and dysfunction , 2016, Diabetes/metabolism research and reviews.

[3]  G. Ferrero,et al.  (Epi)genotype–phenotype correlations in Beckwith–Wiedemann syndrome: a paradigm for genomic medicine , 2016, Clinical genetics.

[4]  C. Owen,et al.  Predicting adult obesity from childhood obesity: a systematic review and meta‐analysis , 2016, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[5]  Jean-Christophe Nebel,et al.  Nutrigenomics 2.0: The Need for Ongoing and Independent Evaluation and Synthesis of Commercial Nutrigenomics Tests' Scientific Knowledge Base for Responsible Innovation. , 2016, Omics : a journal of integrative biology.

[6]  Eugene Kolker,et al.  Precision Nutrition 4.0: A Big Data and Ethics Foresight Analysis--Convergence of Agrigenomics, Nutrigenomics, Nutriproteomics, and Nutrimetabolomics. , 2016, Omics : a journal of integrative biology.

[7]  Swneke D. Bailey,et al.  Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study , 2016, Scientific Reports.

[8]  O. Pedersen,et al.  Genome-wide association studies of human adiposity: Zooming in on synapses , 2015, Molecular and Cellular Endocrinology.

[9]  C. Sapienza,et al.  Genetic and epigenetic associations to obesity‐related appetite phenotypes among African–American children , 2015, Pediatric obesity.

[10]  Z. Jinwei,et al.  MicroRNA regulates animal adipocyte differentiation , 2015 .

[11]  Shabana,et al.  Obesity, More than a ‘Cosmetic’ Problem. Current Knowledge and Future Prospects of Human Obesity Genetics , 2015, Biochemical Genetics.

[12]  Y. Kihara,et al.  The relationship between inflammation and neoangiogenesis of epicardial adipose tissue and coronary atherosclerosis based on computed tomography analysis. , 2015, Atherosclerosis.

[13]  C. Fox,et al.  Association Between Visceral and Subcutaneous Adipose Depots and Incident Cardiovascular Disease Risk Factors , 2015, Circulation.

[14]  E. Rosen,et al.  Making Biological Sense of GWAS Data: Lessons from the FTO Locus. , 2015, Cell metabolism.

[15]  P. Stenvinkel Obesity--a disease with many aetiologies disguised in the same oversized phenotype: has the overeating theory failed? , 2015, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[16]  K. Godfrey,et al.  Genome-wide methylation analysis identifies differentially methylated CpG loci associated with severe obesity in childhood , 2015, Epigenetics.

[17]  E. Demerath,et al.  Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci. , 2015, Human molecular genetics.

[18]  C. Greenhill Epigenetics: Obesity-induced hypermethylation of adiponectin gene , 2015, Nature Reviews Endocrinology.

[19]  C. Busch,et al.  Epigenetic activities of flavonoids in the prevention and treatment of cancer , 2015, Clinical Epigenetics.

[20]  Molly A. Hall,et al.  Phenome-Wide Association Studies: Embracing Complexity for Discovery , 2015, Human Heredity.

[21]  J. Oben,et al.  Epigenetics of obesity: beyond the genome sequence , 2015, Current opinion in clinical nutrition and metabolic care.

[22]  G. Vargas-Alarcón,et al.  Adipose Tissue in Metabolic Syndrome: Onset and Progression of Atherosclerosis. , 2015, Archives of medical research.

[23]  T. Lauritzen,et al.  Abdominal Fat Distribution and Cardiovascular Risk in Men and Women With Different Levels of Glucose Tolerance. , 2015, The Journal of clinical endocrinology and metabolism.

[24]  B. Swinburn,et al.  Child and adolescent obesity: part of a bigger picture , 2015, The Lancet.

[25]  M. Ritchie,et al.  Phenome-Wide Association Studies: Leveraging Comprehensive Phenotypic and Genotypic Data for Discovery , 2015, Current Genetic Medicine Reports.

[26]  C. Martinez-Jimenez,et al.  Epigenetic crosstalk: a molecular language in human metabolic disorders. , 2015, Frontiers in bioscience.

[27]  C. di Pompéo,et al.  Body mass index and childhood obesity classification systems: A comparison of the French, International Obesity Task Force (IOTF) and World Health Organization (WHO) references. , 2015, Revue d'epidemiologie et de sante publique.

[28]  S. Allen,et al.  The Phenome-Wide Distribution of Genetic Variance , 2015, The American Naturalist.

[29]  Christine W. Duarte,et al.  Discovery of phenotypic networks from genotypic association studies with application to obesity , 2015, Int. J. Data Min. Bioinform..

[30]  J. Moreno-Navarrete,et al.  Inflammation triggers specific microRNA profiles in human adipocytes and macrophages and in their supernatants , 2015, Clinical Epigenetics.

[31]  O. Pedersen,et al.  Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood. , 2015, Human molecular genetics.

[32]  Jennifer R Harris,et al.  Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat , 2015, Clinical Epigenetics.

[33]  F. Ashcroft,et al.  Pharmacological Inhibition of FTO , 2015, PloS one.

[34]  S. D. de Ferranti,et al.  Associations of total and abdominal adiposity with risk marker patterns in children at high-risk for cardiovascular disease , 2015, BMC Obesity.

[35]  Peter Arner,et al.  MicroRNA regulatory networks in human adipose tissue and obesity , 2015, Nature Reviews Endocrinology.

[36]  C. Bouchard,et al.  Are there genetic paths common to obesity, cardiovascular disease outcomes, and cardiovascular risk factors? , 2015, Circulation research.

[37]  Z. Mohamed,et al.  Obesity and genomics: role of technology in unraveling the complex genetic architecture of obesity , 2015, Human Genetics.

[38]  Subit Barua,et al.  Lifestyle, pregnancy and epigenetic effects. , 2015, Epigenomics.

[39]  J. Speakman The ‘Fat Mass and Obesity Related’ (FTO) gene: Mechanisms of Impact on Obesity and Energy Balance , 2015, Current Obesity Reports.

[40]  M. Ross,et al.  Epigenomics, gestational programming and risk of metabolic syndrome , 2015, International Journal of Obesity.

[41]  Tao Huang,et al.  Gene-environment interactions and obesity: recent developments and future directions , 2015, BMC Medical Genomics.

[42]  M. Simmonds,et al.  The use of measures of obesity in childhood for predicting obesity and the development of obesity-related diseases in adulthood: a systematic review and meta-analysis. , 2015, Health technology assessment.

[43]  Yong-ling Ye,et al.  Parental Weight Status and Offspring Cardiovascular Disease Risks: a Cross-Sectional Study of Chinese Children , 2015, Preventing chronic disease.

[44]  A. Astrup,et al.  Personalized weight loss strategies—the role of macronutrient distribution , 2014, Nature Reviews Endocrinology.

[45]  P. Portincasa,et al.  Fat, epigenome and pancreatic diseases. Interplay and common pathways from a toxic and obesogenic environment. , 2014, European journal of internal medicine.

[46]  N. Wareham,et al.  Epidemiology of diabetes , 2014, Medicine.

[47]  E. Demerath,et al.  Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference , 2014, Obesity.

[48]  Marylyn D. Ritchie,et al.  Controlling for population structure and genotyping platform bias in the eMERGE multi-institutional biobank linked to electronic health records , 2014, Front. Genet..

[49]  A. Morris,et al.  Associations of genetic variants in/near body mass index‐associated genes with type 2 diabetes: a systematic meta‐analysis , 2014, Clinical endocrinology.

[50]  K. Rajender Rao,et al.  Genetic & epigenetic approach to human obesity , 2014, The Indian journal of medical research.

[51]  V. Somers,et al.  Normal-Weight Obesity: Implications for Cardiovascular Health , 2014, Current Atherosclerosis Reports.

[52]  Li Li,et al.  Phenomics of Vascular Disease: The Systematic Approach to the Combination Therapy , 2014, Current vascular pharmacology.

[53]  A. Morris,et al.  Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci , 2014, Human molecular genetics.

[54]  V. Bollati,et al.  Nutrients Intake Is Associated with DNA Methylation of Candidate Inflammatory Genes in a Population of Obese Subjects , 2014, Nutrients.

[55]  J. Rey-Lopez,et al.  The prevalence of metabolically healthy obesity: a systematic review and critical evaluation of the definitions used , 2014, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[56]  Lucia Migliore,et al.  Obesity and diabetes: from genetics to epigenetics , 2014, Molecular Biology Reports.

[57]  M. S. Almén,et al.  Genome-wide analysis reveals DNA methylation markers that vary with both age and obesity. , 2014, Gene.

[58]  Suzette J. Bielinski,et al.  Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index , 2014, Front. Genet..

[59]  Sang-Woon Choi,et al.  Epigenetic Mechanisms Underlying the Link between Non-Alcoholic Fatty Liver Diseases and Nutrition , 2014, Nutrients.

[60]  G. Galimberti,et al.  A candidate gene association study for nine economically important traits in Italian Holstein cattle. , 2014, Animal genetics.

[61]  Nicholette D. Palmer,et al.  Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes , 2014, PLoS genetics.

[62]  K. Martin,et al.  Pharmacogenetics of obesity drug therapy. , 2014, Current molecular medicine.

[63]  W. D. Vega,et al.  Maternal high-fat diet alters anxiety behavior and glucocorticoid signaling in adolescent offspring , 2014, Neuroscience.

[64]  O. Devuyst Genome-Wide Methylation and Body-Mass Index , 2014, Peritoneal Dialysis International.

[65]  J. Mill,et al.  Epigenetics in health and disease: heralding the EWAS era , 2014, The Lancet.

[66]  Xia Yang,et al.  The Pathogenesis of Obesity from a Genomic and Systems Biology Perspective , 2014, The Yale journal of biology and medicine.

[67]  H. Schatten,et al.  Maternal Diabetes Mellitus and the Origin of Non-Communicable Diseases in Offspring: The Role of Epigenetics1 , 2014, Biology of reproduction.

[68]  Cassandra Willyard Heritability: The family roots of obesity , 2014, Nature.

[69]  A. S. Richardson,et al.  Moderate to vigorous physical activity interactions with genetic variants and body mass index in a large US ethnically diverse cohort , 2014, Pediatric obesity.

[70]  G. Radaelli,et al.  Epigenetic Effects of Human Breast Milk , 2014, Nutrients.

[71]  P. Froguel,et al.  Novel LEPR mutations in obese Pakistani children identified by PCR‐based enrichment and next generation sequencing , 2014, Obesity.

[72]  G. Omenn,et al.  Epigenetics: relevance and implications for public health. , 2014, Annual review of public health.

[73]  N. Cox,et al.  Obesity-associated variants within FTO form long-range functional connections with IRX3 , 2014, Nature.

[74]  J. Harrington,et al.  Nutrigenetics: Bridging Two Worlds to Understand Type 2 Diabetes , 2014, Current Diabetes Reports.

[75]  Erik Ingelsson,et al.  Genome-wide association studies of obesity and metabolic syndrome , 2014, Molecular and Cellular Endocrinology.

[76]  P. Froguel,et al.  Highly Sensitive Diagnosis of 43 Monogenic Forms of Diabetes or Obesity Through One-Step PCR-Based Enrichment in Combination With Next-Generation Sequencing , 2014, Diabetes Care.

[77]  Iftikhar J. Kullo,et al.  Return of results in the genomic medicine projects of the eMERGE network , 2014, Front. Genet..

[78]  E. Iversen,et al.  Maternal Stress, Preterm Birth, and DNA Methylation at Imprint Regulatory Sequences in Humans , 2014, Genetics & epigenetics.

[79]  D. Gauguier,et al.  Nutrigenomics of High Fat Diet Induced Obesity in Mice Suggests Relationships between Susceptibility to Fatty Liver Disease and the Proteasome , 2013, PloS one.

[80]  Melissa A. Basford,et al.  Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data , 2013, Nature Biotechnology.

[81]  Patrice Degoulet,et al.  Phenome-Wide Association Studies on a Quantitative Trait: Application to TPMT Enzyme Activity and Thiopurine Therapy in Pharmacogenomics , 2013, PLoS Comput. Biol..

[82]  Carol J. Bult,et al.  Mouse Phenome Database , 2013, Nucleic Acids Res..

[83]  R. Schwenk,et al.  Genetic and epigenetic control of metabolic health. , 2013, Molecular metabolism.

[84]  C. Rooryck,et al.  Early-onset obesity and paternal 2pter deletion encompassing the ACP1, TMEM18, and MYT1L genes , 2013, European Journal of Human Genetics.

[85]  Jing Yuan,et al.  Genome-wide association study on serum alkaline phosphatase levels in a Chinese population , 2013, BMC Genomics.

[86]  Eric Farber-Eger,et al.  Fine Mapping and Identification of BMI Loci in African Americans. , 2013, American journal of human genetics.

[87]  J. Kang Nutrigenomics and Cancer Therapy , 2013, Lifestyle Genomics.

[88]  Timothy E. Reddy,et al.  The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study. , 2013, Human molecular genetics.

[89]  A. Frazier-Wood,et al.  Epigenetics and Obesity: A Relationship Waiting to Be Explained , 2013, Human Heredity.

[90]  A. Palou,et al.  Challenges in obesity research. , 2013, Nutricion hospitalaria.

[91]  E. Demerath,et al.  Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. , 2013, Human molecular genetics.

[92]  D. Do,et al.  Genome-Wide Association Study Reveals Genetic Architecture of Eating Behavior in Pigs and Its Implications for Humans Obesity by Comparative Mapping , 2013, PloS one.

[93]  L. Ferguson Nutrigenetics, nutrigenomics and inflammatory bowel diseases , 2013, Expert review of clinical immunology.

[94]  E. Demerath,et al.  Gene-by-age effects on BMI from Birth to Adulthood: The Fels Longitudinal Study , 2013, Obesity.

[95]  T. Manolio,et al.  Genetic Variants That Confer Resistance to Malaria Are Associated with Red Blood Cell Traits in African-Americans: An Electronic Medical Record-based Genome-Wide Association Study , 2013, G3: Genes, Genomes, Genetics.

[96]  F. Milagro,et al.  Dietary factors, epigenetic modifications and obesity outcomes: progresses and perspectives. , 2013, Molecular aspects of medicine.

[97]  J. DiBaise,et al.  Role of the gastroenterologist in managing obesity , 2013, Expert review of gastroenterology & hepatology.

[98]  Audrey Y. Chu,et al.  Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry , 2013, PLoS genetics.

[99]  Ryo Maekawa,et al.  Genome-Wide DNA Methylation Analysis Reveals a Potential Mechanism for the Pathogenesis and Development of Uterine Leiomyomas , 2013, PloS one.

[100]  S. Purcell,et al.  Pleiotropy in complex traits: challenges and strategies , 2013, Nature Reviews Genetics.

[101]  Melissa A. Basford,et al.  The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future , 2013, Genetics in Medicine.

[102]  Leif Groop,et al.  A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue , 2013, PLoS genetics.

[103]  J. Kang Gut Microbiota and Personalized Nutrition , 2013, Lifestyle Genomics.

[104]  Priyamvadah Kinth,et al.  Nutrigenomics research: a review , 2013, Journal of Food Science and Technology.

[105]  J. Moreno-Navarrete,et al.  Targeting the circulating microRNA signature of obesity. , 2013, Clinical chemistry.

[106]  D. Gu,et al.  Genome-wide Linkage and Regional Association Study of Obesity-related Phenotypes: The GenSalt study , 2013, Obesity.

[107]  L. Chan,et al.  Nutrigenetics and Nutrigenomics of Atherosclerosis , 2013, Current Atherosclerosis Reports.

[108]  E. Hyppönen,et al.  Parental obesity and risk factors for cardiovascular disease among their offspring in mid-life: findings from the 1958 British Birth Cohort Study , 2013, International Journal of Obesity.

[109]  Inês Barroso,et al.  Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity , 2013, Nature Genetics.

[110]  Thomas W. Mühleisen,et al.  Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture , 2013, Nature Genetics.

[111]  D. Duan Phenomics of cardiac chloride channels. , 2013, Comprehensive Physiology.

[112]  F. Karpe,et al.  MicroRNAs in adipose tissue: their role in adipogenesis and obesity , 2013, International Journal of Obesity.

[113]  C. Gieger,et al.  Gene Set of Nuclear-Encoded Mitochondrial Regulators Is Enriched for Common Inherited Variation in Obesity , 2013, PloS one.

[114]  U. Ekelund,et al.  Evaluation of common genetic variants identified by GWAS for early onset and morbid obesity in population-based samples , 2013, International Journal of Obesity.

[115]  Jong-Young Lee,et al.  Identification of a genetic locus on chromosome 4q34-35 for type 2 diabetes with overweight , 2013, Experimental & Molecular Medicine.

[116]  C. Carlson,et al.  Genetic variation associated with circulating monocyte count in the eMERGE Network. , 2013, Human molecular genetics.

[117]  S. Ozanne,et al.  Maternal diet-induced obesity and offspring cardiovascular health , 2013, Journal of Developmental Origins of Health and Disease.

[118]  Catherine M. Phillips,et al.  Nutrigenetics and Metabolic Disease: Current Status and Implications for Personalised Nutrition , 2013, Nutrients.

[119]  Dana C. Crawford,et al.  A Systematic Mapping Approach of 16q12.2/FTO and BMI in More Than 20,000 African Americans Narrows in on the Underlying Functional Variation: Results from the Population Architecture using Genomics and Epidemiology (PAGE) Study , 2013, PLoS genetics.

[120]  Marylyn D. Ritchie,et al.  Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network , 2013, PLoS genetics.

[121]  A. Martí,et al.  Statistical and Biological Gene-Lifestyle Interactions of MC4R and FTO with Diet and Physical Activity on Obesity: New Effects on Alcohol Consumption , 2012, PloS one.

[122]  R. Mayeux,et al.  Genetic Variants in the Fat and Obesity Associated (FTO) Gene and Risk of Alzheimer's Disease , 2012, PloS one.

[123]  L. Byberg,et al.  Parental influences on cardiovascular risk factors in Swedish children aged 5-14 years. , 2012, European journal of public health.

[124]  K. Lillycrop,et al.  Epigenetic mechanisms linking early nutrition to long term health. , 2012, Best practice & research. Clinical endocrinology & metabolism.

[125]  Vaneet Lotay,et al.  Can Genetic Pleiotropy Replicate Common Clinical Constellations of Cardiovascular Disease and Risk? , 2012, PloS one.

[126]  Joel Eriksson,et al.  FTO genotype is associated with phenotypic variability of body mass index , 2012, Nature.

[127]  F. Takeuchi,et al.  Common polymorphism near the MC4R gene is associated with type 2 diabetes: data from a meta-analysis of 123,373 individuals , 2012, Diabetologia.

[128]  G. Mitchell,et al.  MicroRNAs in Insulin Resistance and Obesity , 2012, Experimental diabetes research.

[129]  Guoyao Wu,et al.  Nutrition, epigenetics, and metabolic syndrome. , 2012, Antioxidants & redox signaling.

[130]  T. Hansen,et al.  Beyond the fourth wave of genome-wide obesity association studies , 2012, Nutrition & Diabetes.

[131]  H. Snieder,et al.  Gene–Lifestyle Interactions in Obesity , 2012, Current Nutrition Reports.

[132]  S. Phelan,et al.  Early Determinants of Obesity: Genetic, Epigenetic, and In Utero Influences , 2012, International journal of pediatrics.

[133]  R Fredriksson,et al.  Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted sequencing in obese and lean children , 2012, International Journal of Obesity.

[134]  A. Näär,et al.  MicroRNAs in metabolism and metabolic disorders , 2012, Nature Reviews Molecular Cell Biology.

[135]  M. Zeegers,et al.  Heritability of body mass index in pre-adolescence, young adulthood and late adulthood , 2012, European Journal of Epidemiology.

[136]  G. Chrousos,et al.  Genome wide analysis reveals association of a FTO gene variant with epigenetic changes. , 2012, Genomics.

[137]  J. Kennedy,et al.  Pharmacogenetics of antipsychotic-induced weight gain: review and clinical implications , 2012, Molecular Psychiatry.

[138]  M. Ashwell,et al.  Waist‐to‐height ratio is a better screening tool than waist circumference and BMI for adult cardiometabolic risk factors: systematic review and meta‐analysis , 2012, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[139]  J. Milner,et al.  Nutrigenomics and Cancer Prevention , 2012, Current Nutrition Reports.

[140]  M. Tester,et al.  Phenomics--technologies to relieve the phenotyping bottleneck. , 2011, Trends in plant science.

[141]  Dana C Crawford,et al.  Pitfalls of merging GWAS data: lessons learned in the eMERGE network and quality control procedures to maintain high data quality , 2011, Genetic epidemiology.

[142]  F. Agakov,et al.  Abundant pleiotropy in human complex diseases and traits. , 2011, American journal of human genetics.

[143]  B. Swinburn,et al.  The global obesity pandemic: shaped by global drivers and local environments , 2011, The Lancet.

[144]  Christopher G. Chute,et al.  Mapping clinical phenotype data elements to standardized metadata repositories and controlled terminologies: the eMERGE Network experience , 2011, J. Am. Medical Informatics Assoc..

[145]  T. Hansen,et al.  Genome wide association study identifies KCNMA1 contributing to human obesity , 2011, BMC Medical Genomics.

[146]  T. Frayling,et al.  An FTO variant is associated with Type 2 diabetes in South Asian populations after accounting for body mass index and waist circumference , 2011, Diabetic medicine : a journal of the British Diabetic Association.

[147]  S. Sebert,et al.  The Obesity Epidemic: From the Environment to Epigenetics – Not Simply a Response to Dietary Manipulation in a Thermoneutral Environment , 2011, Front. Gene..

[148]  C Kooperberg,et al.  The use of phenome‐wide association studies (PheWAS) for exploration of novel genotype‐phenotype relationships and pleiotropy discovery , 2011, Genetic epidemiology.

[149]  K. Ono MicroRNA links obesity and impaired glucose metabolism , 2011, Cell Research.

[150]  Cecilia M. Lindgren,et al.  Genetics and epigenetics of obesity , 2011, Maturitas.

[151]  W. Garver Gene-Diet Interactions in Childhood Obesity , 2011, Current genomics.

[152]  I. Farooqi Genetic, molecular and physiological insights into human obesity , 2011, European journal of clinical investigation.

[153]  J. Timmons,et al.  Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity , 2011, BMC endocrine disorders.

[154]  Jonas Wittwer,et al.  Nutrigenomics in human intervention studies: current status, lessons learned and future perspectives. , 2011, Molecular nutrition & food research.

[155]  M. García-Closas,et al.  The Obesity-Associated Polymorphisms FTO rs9939609 and MC4R rs17782313 and Endometrial Cancer Risk in Non-Hispanic White Women , 2011, PloS one.

[156]  B. Stranger,et al.  Progress and Promise of Genome-Wide Association Studies for Human Complex Trait Genetics , 2011, Genetics.

[157]  R. Sacco,et al.  Genome-wide linkage and peak-wide association study of obesity-related quantitative traits in Caribbean Hispanics , 2011, Human Genetics.

[158]  Wendy A. Wolf,et al.  The eMERGE Network: A consortium of biorepositories linked to electronic medical records data for conducting genomic studies , 2011, BMC Medical Genomics.

[159]  I. Farooqi FTO and obesity: the missing link. , 2011, Cell metabolism.

[160]  Farooq Ahmed Epigenetics: Tales of adversity , 2010, Nature.

[161]  Huidong Shi,et al.  Obesity related methylation changes in DNA of peripheral blood leukocytes , 2010, BMC medicine.

[162]  S. Omholt,et al.  Phenomics: the next challenge , 2010, Nature Reviews Genetics.

[163]  N. Schork,et al.  FTO influences on longitudinal BMI over childhood and adulthood and modulation on relationship between birth weight and longitudinal BMI , 2010, Human Genetics.

[164]  J. Wardle,et al.  Comparing maternal and paternal intergenerational transmission of obesity risk in a large population-based sample. , 2010, The American journal of clinical nutrition.

[165]  H. Heneghan,et al.  Role of microRNAs in obesity and the metabolic syndrome , 2010, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[166]  C. Bouchard,et al.  Advances in exercise, fitness, and performance genomics. , 2010, Medicine and science in sports and exercise.

[167]  H. Snieder,et al.  FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth , 2010, BMC Medical Genetics.

[168]  S. Yusuf,et al.  Anthropometric measures and glucose levels in a large multi-ethnic cohort of individuals at risk of developing type 2 diabetes , 2010, Diabetologia.

[169]  M. Sjöström,et al.  Attenuation of the effect of the FTO rs9939609 polymorphism on total and central body fat by physical activity in adolescents: the HELENA study. , 2010, Archives of pediatrics & adolescent medicine.

[170]  Marylyn D. Ritchie,et al.  PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene–disease associations , 2010, Bioinform..

[171]  G. Parati,et al.  Normal weight obesity: a risk factor for cardiometabolic dysregulation and cardiovascular mortality. , 2010, European heart journal.

[172]  J. Hebebrand,et al.  From monogenic to polygenic obesity: recent advances , 2010, European Child & Adolescent Psychiatry.

[173]  J. Moreno-Navarrete,et al.  MiRNA Expression Profile of Human Subcutaneous Adipose and during Adipocyte Differentiation , 2010, PloS one.

[174]  W. Bao,et al.  A genetic variation in the fat mass‐ and obesity‐associated gene is associated with obesity and newly diagnosed type 2 diabetes in a Chinese population , 2010, Diabetes/metabolism research and reviews.

[175]  M. Engler Nutrigenomics in cardiovascular disease: implications for the future. , 2009, Progress in cardiovascular nursing.

[176]  R. Plomin,et al.  Common disorders are quantitative traits , 2009, Nature Reviews Genetics.

[177]  D. Corella,et al.  Nutrigenomics in Cardiovascular Medicine , 2009, Circulation. Cardiovascular genetics.

[178]  Tyrone D. Cannon,et al.  Phenomics: the systematic study of phenotypes on a genome-wide scale , 2009, Neuroscience.

[179]  F. Kronenberg,et al.  Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design? , 2009, PLoS genetics.

[180]  Thomas J. H. Chen,et al.  Nutrigenomic targeting of carbohydrate craving behavior: can we manage obesity and aberrant craving behaviors with neurochemical pathway manipulation by Immunological Compatible Substances (nutrients) using a Genetic Positioning System (GPS) Map? , 2009, Medical hypotheses.

[181]  F. Milagro,et al.  Individuality and epigenetics in obesity , 2009, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[182]  S. Sookoian,et al.  Maternal Pregestational BMI Is Associated With Methylation of the PPARGC1A Promoter in Newborns , 2009, Obesity.

[183]  Yan Guo,et al.  Genome-wide association study suggested copy number variation may be associated with body mass index in the Chinese population , 2009, Journal of Human Genetics.

[184]  A. Ardekani,et al.  Nutrigenomics and Cancer , 2009, Avicenna journal of medical biotechnology.

[185]  M. Fasshauer,et al.  MicroRNA Expression in Human Omental and Subcutaneous Adipose Tissue , 2009, PloS one.

[186]  Barbara Heude,et al.  Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations , 2009, Nature Genetics.

[187]  S. R. Kulkarni,et al.  FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians , 2009, Diabetologia.

[188]  R. Hegele,et al.  Hypertriglyceridemia: phenomics and genomics , 2009, Molecular and Cellular Biochemistry.

[189]  R. Waterland Is Epigenetics an Important Link between Early Life Events and Adult Disease? , 2009, Hormone Research in Paediatrics.

[190]  C. Warden,et al.  Gene–Nutrient and Gene–Physical Activity Summary—Genetics Viewpoint , 2008, Obesity.

[191]  W. James,et al.  WHO recognition of the global obesity epidemic , 2008, International Journal of Obesity.

[192]  M. Marmot,et al.  The FTO Gene and Obesity in a Large Eastern European Population Sample: The HAPIEE Study , 2008, Obesity.

[193]  B. Godard,et al.  Nutrigenomics and personalized diet: from molecule to intervention and nutri-ethics. , 2008, Omics : a journal of integrative biology.

[194]  E. Rampersaud,et al.  Physical activity and the association of common FTO gene variants with body mass index and obesity. , 2008, Archives of internal medicine.

[195]  C. Sen,et al.  Nutrigenomic basis of beneficial effects of chromium(III) on obesity and diabetes , 2008, Molecular and Cellular Biochemistry.

[196]  Philippe Froguel,et al.  Common genetic variation near MC4R is associated with waist circumference and insulin resistance , 2008, Nature Genetics.

[197]  A. Bird,et al.  DNA methylation landscapes: provocative insights from epigenomics , 2008, Nature Reviews Genetics.

[198]  Subhajyoti De,et al.  Common variants near MC4R are associated with fat mass, weight and risk of obesity , 2008, Nature Genetics.

[199]  R. Hegele,et al.  Genetics of metabolic syndrome: Is there a role for phenomics? , 2008, Current atherosclerosis reports.

[200]  L. Groop,et al.  Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study) , 2008, Diabetologia.

[201]  M. Camilleri,et al.  Pharmacogenetics: potential role in the treatment of diabetes and obesity , 2008, Expert opinion on pharmacotherapy.

[202]  J. Lovegrove,et al.  Nutrigenetics and CVD: what does the future hold? , 2008, Proceedings of the Nutrition Society.

[203]  W. Chung,et al.  Regulation of Fto/Ftm gene expression in mice and humans. , 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

[204]  R. Tracy ‘Deep phenotyping’: characterizing populations in the era of genomics and systems biology , 2008, Current opinion in lipidology.

[205]  A. Tahrani,et al.  Body volume index: time to replace body mass index? , 2008 .

[206]  Yoshiji Yamada,et al.  Genetic factors for human obesity , 2008, Cellular and Molecular Life Sciences.

[207]  M. Malavolti,et al.  Metabolic syndrome: a child is not a small adult. , 2008, International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity.

[208]  R. Bilder Phenomics: Building Scaffolds for Biological Hypotheses in the Post-Genomic Era , 2008, Biological Psychiatry.

[209]  G. Gaetano,et al.  Nutrigenomics: a case for the common soil between cardiovascular disease and cancer , 2008, Genes & Nutrition.

[210]  J. Hebebrand,et al.  Polygenic Obesity in Humans , 2008, Obesity Facts.

[211]  T. Hansen,et al.  Low Physical Activity Accentuates the Effect of the FTO rs9939609 Polymorphism on Body Fat Accumulation , 2008, Diabetes.

[212]  R. Jirtle,et al.  Environmental epigenomics in human health and disease , 2008, Environmental and molecular mutagenesis.

[213]  F. Hu,et al.  Variants in the Fat Mass–and Obesity-Associated (FTO) Gene Are Not Associated With Obesity in a Chinese Han Population , 2008, Diabetes.

[214]  Harald Grallert,et al.  Genome Wide Association (GWA) Study for Early Onset Extreme Obesity Supports the Role of Fat Mass and Obesity Associated Gene (FTO) Variants , 2007, PloS one.

[215]  James Strait,et al.  Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits , 2007, PLoS genetics.

[216]  A. Bird Perceptions of epigenetics , 2007, Nature.

[217]  R. Jirtle,et al.  Epigenetic gene regulation: linking early developmental environment to adult disease. , 2007, Reproductive toxicology.

[218]  C. Davis Nutrigenomics and the prevention of colon cancer. , 2007, Pharmacogenomics.

[219]  B. Caballero,et al.  Epidemic of childhood obesity: implications for kidney disease. , 2006, Advances in chronic kidney disease.

[220]  Karine Clément,et al.  Genetics of human obesity. , 2006, The Proceedings of the Nutrition Society.

[221]  E. Ur,et al.  The obesity epidemic and its cardiovascular consequences , 2006, Current opinion in cardiology.

[222]  G. Faulkner,et al.  Pharmacologic and Nonpharmacologic Strategies for Weight Gain and Metabolic Disturbance in Patients Treated with Antipsychotic Medications , 2006, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[223]  S. Chinn,et al.  Definitions of childhood obesity: current practice , 2006, European Journal of Clinical Nutrition.

[224]  P. Dubbert,et al.  Overweight and obesity: prevalence, consequences, and causes of a growing public health problem. , 2006, The American journal of the medical sciences.

[225]  M. Horlick,et al.  Body mass index and body fatness in childhood , 2005, Current opinion in clinical nutrition and metabolic care.

[226]  J. Manson,et al.  Body mass index and mortality among US male physicians. , 2004, Annals of epidemiology.

[227]  P. James,et al.  Obesity: the worldwide epidemic. , 2004, Clinics in dermatology.

[228]  R. Hegele Phenomics, lipodystrophy, and the metabolic syndrome. , 2004, Trends in cardiovascular medicine.

[229]  C. Pichard,et al.  Body composition measurements: interpretation finally made easy for clinical use , 2003, Current opinion in clinical nutrition and metabolic care.

[230]  C. Sabatti,et al.  The Human Phenome Project , 2003, Nature Genetics.

[231]  J. Manson,et al.  Obesity, Diabetes, and Coronary Risk in Women , 2002, Journal of cardiovascular risk.

[232]  R. Gerlai Phenomics: fiction or the future? , 2002, Trends in Neurosciences.

[233]  W. Weiss Pharmacotherapy for obesity. , 2002, The New England journal of medicine.

[234]  C. Bouchard,et al.  The effect of sex, age and race on estimating percentage body fat from body mass index: The Heritage Family Study , 2002, International Journal of Obesity.

[235]  E. Snyder,et al.  The human obesity gene map: the 2001 update. , 2002, Obesity research.

[236]  G. Bray,et al.  Clinical evaluation of the overweight patient , 2000, Endocrine.

[237]  G. Plourde Treating obesity. Lost cause or new opportunity? , 2000, Canadian family physician Medecin de famille canadien.

[238]  M. Neale,et al.  Genetic and Environmental Factors in Relative Body Weight and Human Adiposity , 1997, Behavior genetics.

[239]  M D Willard,et al.  Obesity: types and treatments. , 1991, American family physician.

[240]  M. Subramanian,et al.  MicroRNAs in obesity-associated disorders. , 2016, Archives of biochemistry and biophysics.

[241]  Dana C. Crawford,et al.  The detection and characterization of pleiotropy: discovery, progress, and promise , 2016, Briefings Bioinform..

[242]  A. Krook,et al.  Maternal obesity legacy: exercise it away! , 2015, Diabetologia.

[243]  Sanjeeva Srivastava,et al.  Personalized medicine beyond genomics: alternative futures in big data—proteomics, environtome and the social proteome , 2015, Journal of Neural Transmission.

[244]  S. O’Rahilly,et al.  20 YEARS OF LEPTIN Human disorders of leptin action , 2014 .

[245]  A. Luca,et al.  Obesity--a risk factor for cardiovascular diseases. , 2013, Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi.

[246]  Xiao-jing Xu,et al.  Genome wide association study of obesity. , 2013 .

[247]  Michael D. Williams Adipose-derived mesenchymal cell derivation, characterization and differentiation for potential use in cell replacement therapy for diabetes , 2013 .

[248]  F. Milagro,et al.  Epigenetics of obesity and weight loss. , 2013, Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion.

[249]  Honghao Zhou,et al.  Genome wide association study of obesity. , 2013, Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.

[250]  R. Dumitrescu,et al.  Nutrigenomics: implications for breast and colon cancer prevention. , 2012, Methods in molecular biology.

[251]  Tanya M. Teslovich,et al.  Association analyses of 249 , 796 individuals reveal 18 new loci associated with body mass index , 2012 .

[252]  A. Xu,et al.  MicroRNAs and type 2 diabetes/obesity. , 2012, Journal of genetics and genomics = Yi chuan xue bao.

[253]  P. Pérez-Martínez,et al.  Nutrigenetics of the lipoprotein metabolism. , 2012, Molecular nutrition & food research.

[254]  A. Martí,et al.  Evidences on three relevant obesogenes: MC4R, FTO and PPARγ. Approaches for personalized nutrition. , 2011, Molecular nutrition & food research.

[255]  A. Martí,et al.  Nutrigenetics: a tool to provide personalized nutritional therapy to the obese. , 2010, World review of nutrition and dietetics.

[256]  Christian Gieger,et al.  Six new loci associated with body mass index highlight a neuronal influence on body weight regulation , 2009, Nature Genetics.

[257]  Ellen Kampman,et al.  Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity , 2009, Nature Genetics.

[258]  I. Farooqi,et al.  Monogenic human obesity. , 2008, Frontiers of hormone research.

[259]  M. Beydoun,et al.  The obesity epidemic in the United States--gender, age, socioeconomic, racial/ethnic, and geographic characteristics: a systematic review and meta-regression analysis. , 2007, Epidemiologic reviews.

[260]  S. O’Rahilly,et al.  Monogenic obesity in humans. , 2005, Annual review of medicine.

[261]  L. Tapsell,et al.  Lifestyle-gene-drug interactions in relation to the metabolic syndrome. , 2005, World review of nutrition and dietetics.

[262]  M. Alemany The etiologic basis for the classification of obesity. , 1989, Progress in food & nutrition science.

[263]  M. Jarvelin,et al.  References and Notes Supporting Online Material Materials and Methods Som Text Figs. S1 to S7 References a Common Variant in the Fto Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity , 2022 .

[264]  Edinburgh Research Explorer Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution , 2022 .