ECG Signal Denoising using Wavelet for the VLP effective detection on FPGA

The presence of Ventricular Late Potentials (VLP) in an Electrocardiographic signal (ECG) is associated with possible sudden cardiac death, caused by malignant arrhythmia. An effective VLP detection is strongly influenced by the signal noise, thus the ECG needs to be denoised before VLP detection. The objective of this paper is to define a denoising algorithm for enhancing VLP detection in ECGs, useful for implementation on a Field Programmable Gate Array device (FPGA). The method described uses wavelet denoising, implemented as subband coding. The drawbacks of this method are heavy linear distortions undergone by the analyzed signal. This disadvantage is overcome by using an equalization filter for canceling the introduced distortions. The algorithm is defined using MATLAB, then its hardware implementation is designed and simulated in Altera's Quartus software. The synthesized hardware is then verified on the evaluation board DE1-SoC by Terasic, mounting a Cyclone V Intel - Altera FPGA chip. On board processed results and theoretical results are consistent, validating the effectiveness of the designed hardware. Results show that such design could be used for upgrading ECG devices reliability in the field of heart diseases prevention.

[1]  Michael Unser,et al.  A review of wavelets in biomedical applications , 1996, Proc. IEEE.

[2]  R Lazzara,et al.  Recording from the body surface of arrhythmogenic ventricular activity during the S-T segment. , 1978, The American journal of cardiology.

[3]  N. Thakor,et al.  Ventricular late potentials characterization in time-frequency domain by means of a wavelet transform , 1994, IEEE Transactions on Biomedical Engineering.

[4]  Agostino Giorgio,et al.  A Method for Ventricular Late Potentials Detection Using Time-Frequency Representation and Wavelet Denoising , 2012, ISRN cardiology.

[5]  Martin Vetterli,et al.  Wavelets and filter banks: theory and design , 1992, IEEE Trans. Signal Process..

[6]  P. Lander,et al.  The analysis of ventricular late potentials using orthogonal recordings , 1988, IEEE Transactions on Biomedical Engineering.

[7]  Y Li,et al.  Differences of Ventricular Late Potential between Acute STEMI and NSTEMI Patients. , 2013, The West Indian medical journal.

[8]  V Hombach,et al.  Standards for analysis of ventricular late potentials using high-resolution or signal-averaged electrocardiography: a statement by a task force committee of the European Society of Cardiology, the American Heart Association, and the American College of Cardiology. , 1991, Journal of the American College of Cardiology.

[9]  Mang I Vai,et al.  Beat-to-beat ECG ventricular late potentials variance detection by filter bank and wavelet transform as beat-sequence filter , 2004, IEEE Transactions on Biomedical Engineering.

[10]  Tadashi Fujino,et al.  Comparison of Late Potentials for 24 Hours Between Brugada Syndrome and Arrhythmogenic Right Ventricular Cardiomyopathy Using a Novel Signal-Averaging System Based on Holter ECG , 2012, Circulation. Arrhythmia and electrophysiology.

[11]  Satria Mandala,et al.  ECG Parameters for Malignant Ventricular Arrhythmias: A Comprehensive Review , 2017, Journal of medical and biological engineering.

[12]  Jurandir Nadal,et al.  Authors reply to comments on "Line patterns in the mosaic electric properties of human skin-a cross correlation study" , 2003 .

[13]  M Borggrefe,et al.  Recent advances in the identification of patients at risk of ventricular tachyarrhythmias: role of ventricular late potentials. , 1987, Circulation.

[14]  A. Mousa,et al.  Neural network detection of ventricular late potentials in ECG signals using wavelet transform extracted parameters , 2001, 2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society.