Platelet noradrenaline release in patients with familial hypercholesterolaemia

Abstract. We have examined resting and thrombin (0.3 units ml‐1) induced release of noradrenaline by washed platelets from 15 normal subjects and eight patients with heterozygous familial hypercholesterolaemia.

[1]  R. Abbate,et al.  Altered lipid composition and thromboxane A2 formation in platelets from patients affected by IIa hyperlipoproteinemia. , 1988, Thrombosis research.

[2]  J. Yudkin,et al.  Increased mean platelet volume after acute myocardial infarction relates to diabetes and to cardiac failure. , 1988, Diabetes research and clinical practice.

[3]  R. Vandongen,et al.  Distribution of free and sulfate-conjugated catecholamines in human platelets. , 1987, The American journal of physiology.

[4]  D. Betteridge,et al.  Platelet catecholamines and platelet function in normal human subjects. , 1987, Clinical science.

[5]  D. Betteridge,et al.  Stimulus-induced release of endogenous catecholamines from human washed platelets. , 1986, Clinical science.

[6]  N. Ardlie,et al.  Effect on human platelets of catecholamines at levels achieved in the circulation. , 1985, Atherosclerosis.

[7]  D. Betteridge,et al.  The distribution of catecholamines between platelets and plasma in normal human subjects. , 1985, Clinical science.

[8]  M. Pařízková,et al.  Platelet function in hyperlipoproteinaemia. , 1985, Folia haematologica.

[9]  C. Sirtori,et al.  Increased platelet sensitivity and thromboxane B2 formation in type‐II hyperlipoproteinaemic patients , 1984, European journal of clinical investigation.

[10]  J. Betteridge,et al.  Improved liquid-chromatographic determination of catecholamines in platelets. , 1984, Clinical chemistry.

[11]  H. A. Cameron,et al.  Platelet size in myocardial infarction. , 1983, British medical journal.

[12]  J. Martin,et al.  Changes in volume and density of platelets in myocardial infarction. , 1983, British medical journal.

[13]  S. Moncada,et al.  An improved method for washing of human platelets with prostacyclin. , 1983, Thrombosis research.

[14]  S. Julius,et al.  Increased platelet catecholamine content in pheochromocytoma: a diagnostic test in patients with elevated plasma catecholamines. , 1982, The New England journal of medicine.

[15]  V. Kakkar,et al.  Enhanced in vivo platelet release reaction and malondialdehyde formation in patients with hyperlipidemia. , 1981, The American journal of medicine.

[16]  L. Aledort,et al.  Platelet aggregation in relationship to plasma catecholamines in patients with hypertension. , 1979, Atherosclerosis.

[17]  G. Picotti,et al.  CONTENT AND SUBCELLULAR LOCALIZATION OF CATECHOLAMINES AND 5‐HYDROXYTRYPTAMINE IN HUMAN AND ANIMAL BLOOD PLATELETS: MONOAMINE DISTRIBUTION BETWEEN PLATELETS AND PLASMA , 1979, British journal of pharmacology.

[18]  H. J. Olverman,et al.  5‐HYDROXYTRYPTAMINE AND DOPAMINE TRANSPORT BY RAT AND HUMAN BLOOD PLATELETS , 1978, British journal of pharmacology.

[19]  N. Aoki,et al.  Potentiation by collagen or epinephrine of platelet responsiveness to aggregation. The possible role of substance(s) released from platelet membranes. , 1977, The Journal of laboratory and clinical medicine.

[20]  M. Brown,et al.  The low-density lipoprotein pathway and its relation to atherosclerosis. , 1977, Annual review of biochemistry.

[21]  Sara Romero,et al.  Effect of phentolamine on platelet aggregation in patients with pheochromocytoma. , 1975, Thrombosis research.

[22]  R. Colman,et al.  Platelet function in hyperlipoproteinemia. , 1974, The New England journal of medicine.

[23]  A. R. Green,et al.  Mechanisms by which human blood platelets accumulate glycine, gaba and amino acid precursors of putative neurotransmitters , 1972, British journal of pharmacology.

[24]  H. M. Solomon,et al.  The accumulation and metabolism of dopamine by the human platelet , 1970, Clinical pharmacology and therapeutics.

[25]  G. Born,et al.  Uptake, metabolism and release of [3H]‐adrenaline by human platelets , 1970, British journal of pharmacology.

[26]  J. Mustard,et al.  Factors influencing platelet function: adhesion, release, and aggregation. , 1970, Pharmacological reviews.

[27]  H. M. Solomon,et al.  The human platelet as a pharmacologic model for the adrenergic neuron , 1969, Clinical pharmacology and therapeutics.

[28]  J. R. O'brien.  Some Effects of Adrenaline and Anti-Adrenaline Compounds on Platelets in vitro and in vivo , 1963, Nature.

[29]  G. Born,et al.  Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal , 1962, Nature.

[30]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.