Production of the soluble form of KIT, s-KIT, abolishes stem cell factor-induced melanogenesis in human melanocytes.

[1]  D. Kardassis,et al.  Exposure of normal human melanocytes to a tumor promoting phorbol ester reverses growth suppression by transforming growth factor beta , 2008, Journal of cellular physiology.

[2]  L. Larue,et al.  Notch1 and Notch2 receptors influence progressive hair graying in a dose‐dependent manner , 2007, Developmental dynamics : an official publication of the American Association of Anatomists.

[3]  S. Nishikawa,et al.  Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells , 2006, The Journal of cell biology.

[4]  Johan Lennartsson,et al.  Normal and Oncogenic Forms of the Receptor Tyrosine Kinase Kit , 2005, Stem cells.

[5]  A. Hachiya,et al.  Biphasic expression of two paracrine melanogenic cytokines, stem cell factor and endothelin-1, in ultraviolet B-induced human melanogenesis. , 2004, The American journal of pathology.

[6]  L. Rönnstrand Signal transduction via the stem cell factor receptor/c-Kit , 2004, Cellular and Molecular Life Sciences CMLS.

[7]  Kyoung-Chan Park,et al.  Transforming growth factor-beta1 decreases melanin synthesis via delayed extracellular signal-regulated kinase activation. , 2004, The international journal of biochemistry & cell biology.

[8]  G. Imokawa,et al.  The epidermal stem cell factor is over-expressed in lentigo senilis: implication for the mechanism of hyperpigmentation. , 2004, The Journal of investigative dermatology.

[9]  M. Kawaguchi,et al.  Localization of tumour necrosis factor‐α converting enzyme in normal human skin , 2004 .

[10]  J. Peschon,et al.  Tumor Necrosis Factor-α-converting Enzyme Controls Surface Expression of c-Kit and Survival of Embryonic Stem Cell-derived Mast Cells* , 2004, Journal of Biological Chemistry.

[11]  R. Black,et al.  TACE/ADAM-17 enzymatic activity is increased in response to cellular stimulation. , 2003, Biochemical and biophysical research communications.

[12]  J. Arribas,et al.  Protein ectodomain shedding. , 2002, Chemical reviews.

[13]  J. Baselga,et al.  Metalloprotease-dependent Protransforming Growth Factor-α Ectodomain Shedding in the Absence of Tumor Necrosis Factor-α-converting Enzyme* , 2001, The Journal of Biological Chemistry.

[14]  G. Imokawa,et al.  The mechanism of epidermal hyperpigmentation in dermatofibroma is associated with stem cell factor and hepatocyte growth factor expression. , 2001, The Journal of investigative dermatology.

[15]  V. Broudy,et al.  The fifth immunoglobulin-like domain of the Kit receptor is required for proteolytic cleavage from the cell surface. , 2001, Cytokine.

[16]  M. Kashima,et al.  Serum levels of soluble stem cell factor and soluble KIT are elevated in patients with atopic dermatitis and correlate with the disease severity , 2001, The British journal of dermatology.

[17]  V. Broudy,et al.  Soluble Kit receptor blocks stem cell factor bioactivity in vitro. , 2001, Leukemia research.

[18]  A. Hachiya,et al.  The paracrine role of stem cell factor/c-kit signaling in the activation of human melanocytes in ultraviolet-B-induced pigmentation. , 2001, The Journal of investigative dermatology.

[19]  G. Imokawa,et al.  Intracellular Signaling Mechanisms Leading to Synergistic Effects of Endothelin-1 and Stem Cell Factor on Proliferation of Cultured Human Melanocytes , 2000, The Journal of Biological Chemistry.

[20]  L. Scott,et al.  Soluble stem cell factor receptor (CD117) and IL-2 receptor alpha chain (CD25) levels in the plasma of patients with mastocytosis: relationships to disease severity and bone marrow pathology. , 2000, Blood.

[21]  A. Joachimiak,et al.  Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[22]  Inoue,et al.  Modulation of melanocyte‐stimulating hormone receptor expression on normal human melanocytes: evidence for a regulatory role of ultraviolet B, interleukin‐1α, interleukin‐1β, endothelin‐1 and tumour necrosis factor‐α , 1998 .

[23]  J. A. Burch,et al.  The SCF/KIT Pathway Plays a Critical Role in the Control of Normal Human Melanocyte Homeostasis , 1998 .

[24]  M. B. Davis,et al.  Endothelin-1 is a paracrine growth factor that modulates melanogenesis of human melanocytes and participates in their responses to ultraviolet radiation. , 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[25]  S. Nishikawa,et al.  Murine Cutaneous Mastocytosis and Epidermal Melanocytosis Induced by Keratinocyte Expression of Transgenic Stem Cell Factor , 1998, The Journal of experimental medicine.

[26]  H. Kawasaki,et al.  Serum soluble c‐kit receptor and expression of c‐kit protein and mRNA in acute myeloid leukemia , 1998, European journal of haematology.

[27]  D. Gawkrodger,et al.  alpha-MSH and melanogenesis in normal human adult melanocytes. , 1998, Pigment cell research.

[28]  V. Broudy,et al.  Stem cell factor and hematopoiesis. , 1997, Blood.

[29]  G. Imokawa,et al.  The role of endothelin-1 in epidermal hyperpigmentation and signaling mechanisms of mitogenesis and melanogenesis. , 1997, Pigment cell research.

[30]  M. Asaka,et al.  Low levels of serum soluble c-kit relates to delayed engraftment after bone marrow transplantation. , 1997, Leukemia and Lymphoma.

[31]  Nicole Nelson,et al.  A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells , 1997, Nature.

[32]  J. Ortonne,et al.  Nitric oxide produced by ultraviolet-irradiated keratinocytes stimulates melanogenesis. , 1997, The Journal of clinical investigation.

[33]  A. Chakraborty,et al.  Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: regulation by ultraviolet B. , 1996, Biochimica et biophysica acta.

[34]  H. Törmä,et al.  Increased expression of inducible nitric oxide synthase in psoriatic skin and cytokine‐stimulated cultured keratinocytes , 1996, The British journal of dermatology.

[35]  S. Nishikawa,et al.  Distinct stages of melanocyte differentiation revealed by anlaysis of nonuniform pigmentation patterns. , 1996, Development.

[36]  B. Gilchrest,et al.  Proopiomelanocortin gene product regulation in keratinocytes. , 1996, The Journal of investigative dermatology.

[37]  G. Imokawa,et al.  Signalling mechanisms of endothelin-induced mitogenesis and melanogenesis in human melanocytes. , 1996, The Biochemical journal.

[38]  S. Nishikawa,et al.  Effects of monoclonal anti-c-kit antibody (ACK2) on melanocytes in newborn mice. , 1995, The Journal of investigative dermatology.

[39]  T. Suda,et al.  Soluble c‐kit molecule in serum from healthy individuals and patients with haemopoietic disorders , 1995, British journal of haematology.

[40]  B. Czarnetzki,et al.  Expression of stem cell factor in cutaneous mastocytosis , 1995, The British journal of dermatology.

[41]  G. Imokawa,et al.  Endothelin-1 as a new melanogen: coordinated expression of its gene and the tyrosinase gene in UVB-exposed human epidermis. , 1995, The Journal of investigative dermatology.

[42]  H. Atkins,et al.  Identification and characterization of a soluble c-kit receptor produced by human hematopoietic cell lines. , 1995, Blood.

[43]  M. Asaka,et al.  Soluble c‐kit levels in acute GVHD after allogeneic bone marrow transplantation , 1995, British journal of haematology.

[44]  S. Boyce,et al.  Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[45]  M. Eisenstein,et al.  The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction , 1995, Cell.

[46]  H. Serve,et al.  Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3'-kinase, and protein kinase C. , 1994, The Journal of biological chemistry.

[47]  F. Trautinger,et al.  Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes. , 1994, The Journal of clinical investigation.

[48]  V. Broudy,et al.  Human umbilical vein endothelial cells display high-affinity c-kit receptors and produce a soluble form of the c-kit receptor , 1994 .

[49]  E. Huang,et al.  The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis. , 1993, Development (Cambridge, England). Supplement.

[50]  H. Langen,et al.  Mechanism of kit ligand, phorbol ester, and calcium-induced down-regulation of c-kit receptors in mast cells. , 1993, The Journal of biological chemistry.

[51]  D. Williams,et al.  Altered metabolism of mast-cell growth factor (c-kit ligand) in cutaneous mastocytosis. , 1993, The New England journal of medicine.

[52]  S. Nishikawa,et al.  Interspecies molecular chimeras of kit help define the binding site of the stem cell factor , 1993, Molecular and cellular biology.

[53]  M. Brizzi,et al.  Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor. , 1993, The Journal of biological chemistry.

[54]  R. Halaban,et al.  White mutants in mice shedding light on humans. , 1993, The Journal of investigative dermatology.

[55]  G. Imokawa,et al.  Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes. , 1992, The Journal of biological chemistry.

[56]  S. Lev,et al.  Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem cell factor. , 1992, The Journal of biological chemistry.

[57]  D. Williams,et al.  The Steel factor. , 1992, Developmental biology.

[58]  R. Spritz,et al.  Dominant negative and loss of function mutations of the c-kit (mast/stem cell growth factor receptor) proto-oncogene in human piebaldism. , 1992, American journal of human genetics.

[59]  C. Heldin,et al.  Activation of the human c‐kit product by ligand‐induced dimerization mediates circular actin reorganization and chemotaxis. , 1991, The EMBO journal.

[60]  R. Spritz,et al.  Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[61]  G. Imokawa,et al.  Effects of endothelins on signal transduction and proliferation in human melanocytes. , 1991, The Journal of biological chemistry.

[62]  S. Nishikawa,et al.  In utero manipulation of coat color formation by a monoclonal anti‐c‐kit antibody: two distinct waves of c‐kit‐dependency during melanocyte development. , 1991, The EMBO journal.

[63]  A. Reith,et al.  The murine W/c-kit and Steel loci and the control of hematopoiesis. , 1991, Seminars in hematology.

[64]  B. Hogan,et al.  Embryonic expression of a haematopoietic growth factor encoded by the SI locus and the ligand for c-kit , 1990, Nature.

[65]  Y. Yarden,et al.  Developmental expression of c-kit, a proto-oncogene encoded by the W locus. , 1990, Development.

[66]  R. Halaban,et al.  Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes , 1988, The Journal of cell biology.

[67]  G. Imokawa,et al.  Selective aberration and pigment loss in melanosomes of malignant melanoma cells in vitro by glycosylation inhibitors: premelanosomes as glycoprotein. , 1983, The Journal of investigative dermatology.

[68]  G. Imokawa,et al.  Loss of melanogenic properties in tyrosinases induced by glucosylation inhibitors within malignant melanoma cells. , 1982, Cancer research.

[69]  G. Szabó,et al.  Mitotic activity of epidermal melanocytes in UV-irradiated mouse skin. , 1978, The Journal of investigative dermatology.

[70]  M. Seiji,et al.  Transfer mechanism of melanosomes in epidermal cell culture. , 1976, The Journal of investigative dermatology.

[71]  Monika Bzowska,et al.  Structure and functions of tumor necrosis factor-alpha converting enzyme. , 2003, Acta biochimica Polonica.

[72]  D. Williams,et al.  Signaling through the interaction of membrane-restricted stem cell factor and c-kit receptor tyrosine kinase: genetic evidence for a differential role in erythropoiesis. , 1998, Blood.

[73]  J. Burn,et al.  Novel mutations and deletions of the KIT (steel factor receptor) gene in human piebaldism. , 1995, American journal of human genetics.

[74]  J. Wypych,et al.  Soluble kit receptor in human serum. , 1995, Blood.

[75]  S. Galli,et al.  The kit ligand, stem cell factor. , 1994, Advances in immunology.

[76]  M. Zamora,et al.  Cultured human keratinocytes synthesize and secrete endothelin-1. , 1993, The Journal of investigative dermatology.