The in vitro effect of hydroxychloroquine on skin morphology and transglutaminase *

Background Antimalarials are some of the most notorious drugs which may induce psoriasis, with 25% of all reported cases being associated with them. Antimalarials do not induce psoriasis de novo, but trigger subclinical psoriasis. In a previous report, we suggested that antimalarials exert their effect by interfering with the epidermal transglutaminase (TGase) activity.

[1]  R. Wolf,et al.  Is transglutaminase the mediator between antimalarial drugs and psoriasis? , 1997, International journal of dermatology.

[2]  V. Ruocco,et al.  Are acantholysis and transglutaminase inhibition related phenomena? , 1996, Dermatology.

[3]  V. Ruocco,et al.  Drug-induced pemphigus. II. Pathomechanisms and experimental investigations. , 1993, Clinics in dermatology.

[4]  P. Elias,et al.  Barrier function regulates epidermal lipid and DNA synthesis , 1993, The British journal of dermatology.

[5]  P. Elias,et al.  From basket weave to barrier. Unifying concepts for the pathogenesis of the disorders of cornification. , 1993, Archives of dermatology.

[6]  D. Hohl,et al.  Analysis of the cornified cell envelope in lamellar ichthyosis. , 1993, Archives of dermatology.

[7]  V. Ruocco,et al.  ENALAPRIL: A POWERFUL IN VITRO NON‐THIOL ACANTHOLYTIC AGENT , 1992, International journal of dermatology.

[8]  P. Elias,et al.  The lovastatin-treated rodent: a new model of barrier disruption and epidermal hyperplasia. , 1991, The Journal of investigative dermatology.

[9]  M. Frick.  Exacerbation of psoriasis. , 1989, Archives of dermatology.

[10]  P. Elias,et al.  Exacerbation of psoriasis by the hypolipidemic agent, gemfibrozil. , 1988, Archives of dermatology.

[11]  V. Ruocco,et al.  In vitro acantholysis by captopril and thiopronine. , 1988, Dermatologica.

[12]  N. Parenteau,et al.  Induction of keratinocyte type-I transglutaminase in epithelial cells of the rat. , 1986, Differentiation; research in biological diversity.

[13]  E. Orenberg,et al.  Drugs in exacerbation of psoriasis. , 1986, Journal of the American Academy of Dermatology.

[14]  R. Rice,et al.  Keratinocyte-specific transglutaminase of cultured human epidermal cells: Relation to cross-linked envelope formation and terminal differentiation , 1985, Cell.

[15]  R. Potter.  Pathogenesis of psoriasis. , 1983, Journal of the American Academy of Dermatology.

[16]  L. Lorand,et al.  Specificity of guinea pig liver transglutaminase for amine substrates. , 1979, Biochemistry.

[17]  J. E. Folk,et al.  Molecular and catalytic properties of transglutaminases. , 1973, Advances in enzymology and related areas of molecular biology.