Curcumin and Cancer

Curcumin, a polyphenol extracted from Curcuma longa in 1815, has gained attention from scientists worldwide for its biological activities (e.g., antioxidant, anti-inflammatory, antimicrobial, antiviral), among which its anticancer potential has been the most described and still remains under investigation. The present review focuses on the cell signaling pathways involved in cancer development and proliferation, and which are targeted by curcumin. Curcumin has been reported to modulate growth factors, enzymes, transcription factors, kinase, inflammatory cytokines, and proapoptotic (by upregulation) and antiapoptotic (by downregulation) proteins. This polyphenol compound, alone or combined with other agents, could represent an effective drug for cancer therapy.

[1]  Chao Pi,et al.  Recent advances of analogues of curcumin for treatment of cancer. , 2019, European journal of medicinal chemistry.

[2]  S. Koutsopoulos,et al.  Synergistic Antitumor Potency of a Self-Assembling Peptide Hydrogel for the Local Co-delivery of Doxorubicin and Curcumin in the Treatment of Head and Neck Cancer. , 2019, Molecular pharmaceutics.

[3]  R. Greil,et al.  Pharmacokinetics of liposomal curcumin (Lipocurc™) infusion: effect of co-medication in cancer patients and comparison with healthy individuals , 2018, Cancer Chemotherapy and Pharmacology.

[4]  M. Rosini,et al.  Immunomodulators Inspired by Nature: A Review on Curcumin and Echinacea , 2018, Molecules.

[5]  Yan Xu,et al.  An LC–MS/MS method for simultaneous determination of curcumin, curcumin glucuronide and curcumin sulfate in a phase II clinical trial , 2018, Journal of pharmaceutical and biomedical analysis.

[6]  M. Filetti,et al.  Effective treatment of a platinum-resistant cutaneous squamous cell carcinoma case by EGFR pathway inhibition. , 2018, Molecular and clinical oncology.

[7]  H. Suleria,et al.  Cucurmin, anticancer, & antitumor perspectives: A comprehensive review , 2018, Critical reviews in food science and nutrition.

[8]  Bo Li,et al.  The effects of Curcumin on HCT‐116 cells proliferation and apoptosis via the miR‐491/PEG10 pathway , 2018, Journal of cellular biochemistry.

[9]  A. Allegra,et al.  Curcumin ameliorates the in vitro efficacy of carfilzomib in human multiple myeloma U266 cells targeting p53 and NF-κB pathways. , 2018, Toxicology in vitro : an international journal published in association with BIBRA.

[10]  A. Giordano,et al.  Antitumoral potential, antioxidant activity and carotenoid content of two Southern Italy tomato cultivars extracts: San Marzano and Corbarino , 2018, Journal of cellular physiology.

[11]  K. Elenitoba-Johnson,et al.  New Insights into Lymphoma Pathogenesis. , 2018, Annual review of pathology.

[12]  Longchang Huang,et al.  Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/β-Catenin Pathways via miR-130a , 2017, Front. Pharmacol..

[13]  A. Sahebkar,et al.  Curcumin: A natural modulator of immune cells in systemic lupus erythematosus. , 2017, Autoimmunity reviews.

[14]  Xiaoquan Yang,et al.  Elaboration of curcumin-loaded rice bran albumin nanoparticles formulation with increased in vitro bioactivity and in vivo bioavailability , 2017 .

[15]  A. Agrawal,et al.  Exosomes for the Enhanced Tissue Bioavailability and Efficacy of Curcumin , 2017, The AAPS Journal.

[16]  Jun Xue,et al.  Curcumin suppresses proliferation and in vitro invasion of human prostate cancer stem cells by ceRNA effect of miR-145 and lncRNA-ROR. , 2017, Gene.

[17]  M. Akram,et al.  Awareness and current knowledge of breast cancer , 2017, Biological Research.

[18]  I. Jantan,et al.  Naturally occurring immunomodulators with antitumor activity: An insight on their mechanisms of action , 2017, International immunopharmacology.

[19]  R. Coletta,et al.  In vivo and in vitro effects of curcumin on head and neck carcinoma: a systematic review , 2017, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[20]  Jianbo Liu,et al.  Curcumin sensitizes prostate cancer cells to radiation partly via epigenetic activation of miR-143 and miR-143 mediated autophagy inhibition , 2017, Journal of drug targeting.

[21]  K. Tao,et al.  Effect and Mechanism of Curcumin on EZH2 - miR-101 Regulatory Feedback Loop in Multiple Myeloma. , 2017, Current pharmaceutical design.

[22]  A. Kunnumakkara,et al.  Specific Targeting of Akt Kinase Isoforms: Taking the Precise Path for Prevention and Treatment of Cancer. , 2017, Current drug targets.

[23]  J. Suo,et al.  Curcumin suppresses colon cancer cell invasion via AMPK-induced inhibition of NF-κB, uPA activator and MMP9. , 2016, Oncology letters.

[24]  Q. Tan,et al.  Catanionic lipid nanosystems improve pharmacokinetics and anti-lung cancer activity of curcumin. , 2016, Nanomedicine : nanotechnology, biology, and medicine.

[25]  J. Snyder,et al.  Inhibition of NF-κB translocation by curcumin analogs induces G0/G1 arrest and downregulates thymidylate synthase in colorectal cancer. , 2016, Cancer letters.

[26]  Yu Zhou,et al.  Curcumin Suppresses Proliferation and Migration of MDA-MB-231 Breast Cancer Cells through Autophagy-Dependent Akt Degradation , 2016, PloS one.

[27]  U. Krishnan,et al.  Combinatorial Effects of Curcumin with an Anti-Neoplastic Agent on Head and Neck Squamous Cell Carcinoma Through the Regulation of EGFR-ERK1/2 and Apoptotic Signaling Pathways. , 2016, ACS combinatorial science.

[28]  Lichuan Wu,et al.  Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathway. , 2015, Oncology reports.

[29]  Hai Jin,et al.  Curcumin inhibits cell proliferation and induces apoptosis of human non-small cell lung cancer cells through the upregulation of miR-192-5p and suppression of PI3K/Akt signaling pathway. , 2015, Oncology reports.

[30]  R. Mehrotra,et al.  Berberine and Curcumin Target Survivin and STAT3 in Gastric Cancer Cells and Synergize Actions of Standard Chemotherapeutic 5-Fluorouracil , 2015, Nutrition and cancer.

[31]  A. Fetoni,et al.  Molecular targets for anticancer redox chemotherapy and cisplatin-induced ototoxicity: the role of curcumin on pSTAT3 and Nrf-2 signalling , 2015, British Journal of Cancer.

[32]  Xin-yang Wang,et al.  Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling , 2015, International journal of oncology.

[33]  Jing-jing Hu,et al.  Curcumin induces the apoptosis of A549 cells via oxidative stress and MAPK signaling pathways. , 2015, International journal of molecular medicine.

[34]  Haofeng Xi,et al.  Curcumin induces apoptosis in pancreatic cancer cells through the induction of forkhead box O1 and inhibition of the PI3K/Akt pathway. , 2015, Molecular medicine reports.

[35]  J. Ligęza,et al.  Modulatory Effects of Curcumin and Tyrphostins (AG494 and AG1478) on Growth Regulation and Viability of LN229 Human Brain Cancer Cells , 2015, Nutrition and cancer.

[36]  R. Ramakrishna,et al.  The Effect of Curcumin (as Meriva) on Absolute Lymphocyte Count (ALC), NK Cells and T Cell Populations in Patients with Stage 0/1 Chronic Lymphocytic Leukemia , 2015 .

[37]  C. Rolfo,et al.  Curcumin inhibits in vitro and in vivo chronic myelogenous leukemia cells growth: a possible role for exosomal disposal of miR-21 , 2015, Oncotarget.

[38]  G. Petersen,et al.  Gene-by-Environment Interactions in Pancreatic Cancer: Implications for Prevention , 2015, The Yale journal of biology and medicine.

[39]  F. Buonaguro,et al.  Update on Head and Neck Cancer: Current Knowledge on Epidemiology, Risk Factors, Molecular Features and Novel Therapies , 2015, Oncology.

[40]  P. Preira,et al.  EGFR Inhibition by Curcumin in Cancer Cells: A Dual Mode of Action. , 2015, Biomacromolecules.

[41]  Gang Xu,et al.  [Curcumin inhibited rat colorectal carcinogenesis by activating PPAR-γ: an experimental study]. , 2015, Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.

[42]  Pınar Obakan,et al.  Inhibition of PI3K signaling triggered apoptotic potential of curcumin which is hindered by Bcl-2 through activation of autophagy in MCF-7 cells. , 2015, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[43]  F. Izzo,et al.  Dissecting the Role of Curcumin in Tumour Growth and Angiogenesis in Mouse Model of Human Breast Cancer , 2015, BioMed research international.

[44]  Jie Fan,et al.  [Curcumin induces apoptosis by PTEN/PI3K/AKT pathway in EC109 cells]. , 2015, Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.

[45]  C. Mathers,et al.  Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 , 2015, International journal of cancer.

[46]  B. Aggarwal,et al.  The Multifaceted Role of Curcumin in Cancer Prevention and Treatment , 2015, Molecules.

[47]  P. Yin,et al.  Ras/ERK signaling pathway is involved in curcumin-induced cell cycle arrest and apoptosis in human gastric carcinoma AGS cells , 2015, Journal of Asian natural products research.

[48]  Xiao-mei Zhang,et al.  Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro , 2015, Anti-cancer drugs.

[49]  Q. Rao,et al.  Role of the Wilms' tumor 1 gene in the aberrant biological behavior of leukemic cells and the related mechanisms. , 2014, Oncology reports.

[50]  G. Wang,et al.  The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway , 2014, Cancer Cell International.

[51]  E. El-Omar,et al.  Genetics of gastric cancer , 2014, Nature Reviews Gastroenterology &Hepatology.

[52]  Zihui Xu,et al.  Curcumin inhibits proliferation of breast cancer cells through Nrf2-mediated down-regulation of Fen1 expression , 2014, The Journal of Steroid Biochemistry and Molecular Biology.

[53]  Mei Lan Tan,et al.  The mTOR signalling pathway in cancer and the potential mTOR inhibitory activities of natural phytochemicals. , 2014, Asian Pacific journal of cancer prevention : APJCP.

[54]  Z. A. Abd Elmageed,et al.  Subverting ER-Stress towards Apoptosis by Nelfinavir and Curcumin Coexposure Augments Docetaxel Efficacy in Castration Resistant Prostate Cancer Cells , 2014, PloS one.

[55]  Kiattawee Choowongkomon,et al.  Computational analyses of curcuminoid analogs against kinase domain of HER2 , 2014, BMC Bioinformatics.

[56]  Zhaoqing Xi,et al.  Curcumin suppresses proliferation and invasion in non-small cell lung cancer by modulation of MTA1-mediated Wnt/β-catenin pathway , 2014, In Vitro Cellular & Developmental Biology - Animal.

[57]  Jing Wu,et al.  Curcumin induces apoptosis in SGC-7901 gastric adenocarcinoma cells via regulation of mitochondrial signaling pathways. , 2014, Asian Pacific journal of cancer prevention : APJCP.

[58]  M. Vinayak,et al.  Curcumin attenuates carcinogenesis by down regulating proinflammatory cytokine interleukin-1 (IL-1α and IL-1β) via modulation of AP-1 and NF-IL6 in lymphoma bearing mice. , 2014, International immunopharmacology.

[59]  A. Bode,et al.  Curcumin Suppresses Proliferation of Colon Cancer Cells by Targeting CDK2 , 2014, Cancer Prevention Research.

[60]  Liyan Jiang,et al.  Curcumin lowers erlotinib resistance in non-small cell lung carcinoma cells with mutated EGF receptor. , 2014, Oncology research.

[61]  M. Sayan,et al.  Curcumin: A Double Hit on Malignant Mesothelioma , 2014, Cancer Prevention Research.

[62]  Ning Li,et al.  Protective effect of curcumin against formaldehyde‐induced genotoxicity in A549 Cell Lines , 2013, Journal of applied toxicology : JAT.

[63]  Roopma Wadhwa,et al.  Gastric cancer—molecular and clinical dimensions , 2013, Nature Reviews Clinical Oncology.

[64]  J. Vishwanatha,et al.  Efficacy of liposomal curcumin in a human pancreatic tumor xenograft model: inhibition of tumor growth and angiogenesis. , 2013, Anticancer research.

[65]  Vicente Micol,et al.  Immunoliposome encapsulation increases cytotoxic activity and selectivity of curcumin and resveratrol against HER2 overexpressing human breast cancer cells , 2013, Breast Cancer Research and Treatment.

[66]  S. Srivastava,et al.  Pancreatic cancer chemoprevention by phytochemicals. , 2013, Cancer letters.

[67]  T. Huh,et al.  Curcumin induces apoptosis in human colorectal carcinoma (HCT-15) cells by regulating expression of Prp4 and p53 , 2013, Molecules and cells.

[68]  Guang Li,et al.  Inhibition of the PI3K/AKT-NF-κB pathway with curcumin enhanced radiation-induced apoptosis in human Burkitt's lymphoma. , 2013, Journal of pharmacological sciences.

[69]  Zhi-jun Yu,et al.  Curcumin Inhibits Proliferation and Induces Apoptosis of Human Colorectal Cancer Cells by Activating the Mitochondria Apoptotic Pathway , 2013, Phytotherapy research : PTR.

[70]  Y. Izumi,et al.  Curcumin Induces Autophagy in ACC‐MESO‐1 Cells , 2012, Phytotherapy research : PTR.

[71]  Dong-Sheng Huang,et al.  Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression. , 2012, Molecular medicine reports.

[72]  Jong-Suk Kim,et al.  Curcumin suppresses the TPA-induced invasion through inhibition of PKCα-dependent MMP-expression in MCF-7 human breast cancer cells. , 2012, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[73]  Yan Pan,et al.  Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of α1‐antitrypsin in lung cancer , 2012, Molecular oncology.

[74]  A. Zanotto-Filho,et al.  The curry spice curcumin selectively inhibits cancer cells growth in vitro and in preclinical model of glioblastoma. , 2012, The Journal of nutritional biochemistry.

[75]  V. Ghalaut,et al.  Effect of imatinib therapy with and without turmeric powder on nitric oxide levels in chronic myeloid leukemia , 2012, Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.

[76]  G. Morgia,et al.  Polyphenols: Key Issues Involved in Chemoprevention of Prostate Cancer , 2012, Oxidative medicine and cellular longevity.

[77]  Vasudha Sundram,et al.  Curcumin Attenuates β-catenin Signaling in Prostate Cancer Cells through Activation of Protein Kinase D1 , 2012, PloS one.

[78]  C. Chi,et al.  Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK Pathways , 2012, BMC Complementary and Alternative Medicine.

[79]  Ying Huang,et al.  Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation. , 2011, Biochemical pharmacology.

[80]  Yu-Tang Tung,et al.  Curcumin reduces pulmonary tumorigenesis in vascular endothelial growth factor (VEGF)-overexpressing transgenic mice. , 2011, Molecular nutrition & food research.

[81]  H. Pass,et al.  Curcumin suppresses growth of mesothelioma cells in vitro and in vivo, in part, by stimulating apoptosis , 2011, Molecular and Cellular Biochemistry.

[82]  L. C. Spolidorio,et al.  Potent anti-inflammatory effects of systemically administered curcumin modulate periodontal disease in vivo. , 2011, Journal of periodontal research.

[83]  S. Lakhani,et al.  Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes , 2010, Oncogene.

[84]  A. Shehzad,et al.  Curcumin in Cancer Chemoprevention: Molecular Targets, Pharmacokinetics, Bioavailability, and Clinical Trials , 2010, Archiv der Pharmazie.

[85]  H. Yin,et al.  Curcumin promotes apoptosis in A549/DDP multidrug-resistant human lung adenocarcinoma cells through an miRNA signaling pathway. , 2010, Biochemical and biophysical research communications.

[86]  T. Udagawa,et al.  Tumor-stromal cell interactions and opportunities for therapeutic intervention. , 2010, Current opinion in pharmacology.

[87]  A. Mantovani,et al.  Molecular pathways linking inflammation and cancer. , 2010, Current molecular medicine.

[88]  M. Kwak,et al.  Targeting NRF2 signaling for cancer chemoprevention. , 2010, Toxicology and applied pharmacology.

[89]  M. K. Lee,et al.  Curcumin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. , 2009, Anticancer research.

[90]  Q. Liu,et al.  Curcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NFkappaB, cyclinD and MMP-1 transcription. , 2009, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[91]  M. Cheng,et al.  Curcumin suppresses proliferation and invasion in human gastric cancer cells by down-regulation of PAK1 activity and cyclin D1 expression , 2009, Cancer biology & therapy.

[92]  G. Sethi,et al.  Potential pharmacological control of the NF-κB pathway. , 2009, Trends in pharmacological sciences.

[93]  Yinghe Hu,et al.  Curcumin induces apoptosis and inhibits growth of human Burkitt’s lymphoma in xenograft mouse model , 2009, Molecules and cells.

[94]  L. Bergmann,et al.  Wilms' tumour gene 1 (WT1) as a target in curcumin treatment of pancreatic cancer cells. , 2009, European journal of cancer.

[95]  T. Shanafelt,et al.  Curcumin Inhibits Prosurvival Pathways in Chronic Lymphocytic Leukemia B Cells and May Overcome Their Stromal Protection in Combination with EGCG , 2009, Clinical Cancer Research.

[96]  T. Hsia,et al.  Effects of curcumin on N-bis(2-hydroxypropyl) nitrosamine (DHPN)-induced lung and liver tumorigenesis in BALB/c mice in vivo. , 2008, In vivo.

[97]  P. Limtrakul,et al.  Effect of pure curcumin, demethoxycurcumin, and bisdemethoxycurcumin on WT1 gene expression in leukemic cell lines , 2008, Cancer Chemotherapy and Pharmacology.

[98]  B. Aggarwal,et al.  Curcumin and cancer: an "old-age" disease with an "age-old" solution. , 2008, Cancer letters.

[99]  Razelle Kurzrock,et al.  Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer , 2008, Clinical Cancer Research.

[100]  S. Joyal,et al.  A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95®CG (Biocurcumax™), A Novel Bioenhanced Preparation of Curcumin , 2008, Indian journal of pharmaceutical sciences.

[101]  J. Milner,et al.  Diet, Autophagy, and Cancer: A Review , 2008, Cancer Epidemiology Biomarkers & Prevention.

[102]  G. D’Souza,et al.  Epidemiology of head and neck cancer , 2008 .

[103]  K. Coombes,et al.  Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells , 2008, Molecular Cancer Therapeutics.

[104]  R. Rosengren,et al.  The combination of epigallocatechin gallate and curcumin suppresses ERα‐breast cancer cell growth in vitro and in vivo , 2007, International journal of cancer.

[105]  N. Shinton.  WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues , 2007 .

[106]  Michael L. Wang,et al.  Curcumin Downregulates NF-kB and Related Genes in Patients with Multiple Myeloma: Results of a Phase I/II Study. , 2007 .

[107]  Wei-dong Cao,et al.  Curcumin induces G2/M cell cycle arrest in a p53-dependent manner and upregulates ING4 expression in human glioma , 2007, Journal of Neuro-Oncology.

[108]  B. Aggarwal,et al.  Targeting Signal‐Transducer‐and‐Activator‐of‐Transcription‐3 for Prevention and Therapy of Cancer , 2006, Annals of the New York Academy of Sciences.

[109]  J. Greif,et al.  Inhibition of pancreatic and lung adenocarcinoma cell survival by curcumin is associated with increased apoptosis, down-regulation of COX-2 and EGFR and inhibition of Erk1/2 activity. , 2006, Anticancer research.

[110]  Jun Cao,et al.  Mitochondrial and nuclear DNA damage induced by curcumin in human hepatoma G2 cells. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[111]  A. Kong,et al.  Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin. , 2006, Carcinogenesis.

[112]  Razelle Kurzrock,et al.  Liposome‐encapsulated curcumin , 2005, Cancer.

[113]  Yufeng Shi,et al.  Curcumin-induced histone hypoacetylation: the role of reactive oxygen species. , 2005, Biochemical pharmacology.

[114]  B. Aggarwal,et al.  Nuclear factor‐κB and IκB kinase are constitutively active in human pancreatic cells, and their down‐regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis , 2004, Cancer.

[115]  M. Pirmohamed,et al.  Phase I Clinical Trial of Oral Curcumin , 2004, Clinical Cancer Research.

[116]  R. Nusse,et al.  The Wnt signaling pathway in development and disease. , 2004, Annual review of cell and developmental biology.

[117]  B. Aggarwal,et al.  Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells 1 , 2003, The Journal of Immunology.

[118]  Jiuhong Kang,et al.  Nickel-induced histone hypoacetylation: the role of reactive oxygen species. , 2003, Toxicological sciences : an official journal of the Society of Toxicology.

[119]  Zhen-zhou Shen,et al.  Curcumin exerts multiple suppressive effects on human breast carcinoma cells , 2002, International journal of cancer.

[120]  B. Aggarwal,et al.  Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines , 2001, Oncogene.

[121]  C. Boland,et al.  Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells. , 2001, Cancer letters.

[122]  Y. Yarden.  The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. , 2001, European journal of cancer.

[123]  S. Han,et al.  Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, c-myc, bcl-XL, NF-kappa B, and p53. , 1999, Clinical immunology.

[124]  Jen-kun Lin,et al.  Curcumin Inhibits SK-Hep-1 Hepatocellular Carcinoma Cell Invasion in vitro and Suppresses Matrix Metalloproteinase-9 Secretion , 1998, Oncology.

[125]  B. Aggarwal,et al.  Activation of Transcription Factor NF-κB Is Suppressed by Curcumin (Diferuloylmethane) (*) , 1995, The Journal of Biological Chemistry.

[126]  P. Blitzer,et al.  Epidemiology of head and neck cancer. , 1988, Seminars in oncology.

[127]  D. Generali,et al.  Curcumin as an Adjunct Therapy and microRNA Modulator in Breast Cancer. , 2018, Current pharmaceutical design.

[128]  L. Pearce.  Haematological cancers. , 2016, Nursing standard (Royal College of Nursing (Great Britain) : 1987).

[129]  A. Jemal,et al.  Cancer statistics, 2016 , 2016, CA: a cancer journal for clinicians.

[130]  Jaetae Lee,et al.  Curcumin in various cancers , 2013, BioFactors.

[131]  B. Aggarwal,et al.  Curcumin and liver cancer: a review. , 2012, Current pharmaceutical biotechnology.

[132]  Zhang-qun Ye 叶章群,et al.  Anti-tumor activity of curcumin against androgen-independent prostate cancer cells via inhibition of NF-κB and AP-1 pathway in vitro , 2011, Journal of Huazhong University of Science and Technology [Medical Sciences].

[133]  G. Kuttan,et al.  Antitumor, anti-invasion, and antimetastatic effects of curcumin. , 2007, Advances in experimental medicine and biology.

[134]  P. Limtrakul,et al.  Inhibitory effect of curcumin onWT1 gene expression in patient leukemic cells , 2006, Archives of pharmacal research.

[135]  P. Limtrakul,et al.  Inhibitory effect of curcumin onMDR1 gene expression in patient leukemic cells , 2006, Archives of pharmacal research.

[136]  Y. Yarden,et al.  Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors. , 2000, Advances in cancer research.

[137]  B. Aggarwal,et al.  Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]. , 1995, The Journal of biological chemistry.

[138]  D. Woodfield.  Hepatocellular carcinoma. , 1986, The New Zealand medical journal.

[139]  N. Dubrawsky.  Cancer statistics , 1989, CA: a cancer journal for clinicians.