Effects of PentaLyte® and Voluven® hemodilution on plasma coagulation kinetics in the rabbit: role of thrombin‐fibrinogen and factor XIII‐fibrin polymer interactions

Background:  Hydroxyethyl starch (HES) administration has resulted in decreased hemostasis and fibrinogen (FI)‐thrombin‐(FIIa)‐Factor XIII (FXIII) interactions. I proposed to determine the hemostatic effect of hemodilution with PentaLyte® (6% HES, mean molecular weight 220 kDa) and Voluven® (6% HES, 130 kDa).

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