Nuclear transport receptor karyopherin-α2 promotes malignant breast cancer phenotypes in vitro

[1]  F. Wang,et al.  Octamer 4 Small Interfering RNA Results in Cancer Stem Cell-Like Cell Apoptosis , 2012 .

[2]  Sven Diederichs,et al.  The hallmarks of cancer , 2012, RNA biology.

[3]  Yu-Sun Chang,et al.  Importin subunit alpha‐2 is identified as a potential biomarker for non‐small cell lung cancer by integration of the cancer cell secretome and tissue transcriptome , 2011, International journal of cancer.

[4]  G. Kristiansen,et al.  KPNA2 Expression Is an Independent Adverse Predictor of Biochemical Recurrence after Radical Prostatectomy , 2011, Clinical Cancer Research.

[5]  H. Kuwano,et al.  Significance of Karyopherin-α 2 (KPNA2) Expression in Esophageal Squamous Cell Carcinoma , 2010 .

[6]  N. Klugbauer,et al.  The Nuclear Import of the Small GTPase Rac1 is Mediated by the Direct Interaction with Karyopherin α2 , 2010, Traffic.

[7]  Matthias Ochs,et al.  A review of recent methods for efficiently quantifying immunogold and other nanoparticles using TEM sections through cells, tissues and organs. , 2009, Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft.

[8]  E. Dahl,et al.  Nuclear karyopherin α2 expression predicts poor survival in patients with advanced breast cancer irrespective of treatment intensity , 2008, International journal of cancer.

[9]  C Caldas,et al.  Proliferation markers and survival in early breast cancer: a systematic review and meta-analysis of 85 studies in 32,825 patients. , 2008, Breast.

[10]  E. Dahl,et al.  Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer , 2008, BMC Cancer.

[11]  A. Regev,et al.  An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors , 2008, Nature Genetics.

[12]  G. Kristiansen,et al.  The extracellular matrix protein ITIH5 is a novel prognostic marker in invasive node-negative breast cancer and its aberrant expression is caused by promoter hypermethylation , 2008, Oncogene.

[13]  G. Kristiansen,et al.  KPNA2 protein expression in invasive breast carcinoma and matched peritumoral ductal carcinoma in situ , 2007, Virchows Archiv.

[14]  I. Petersen,et al.  Comparison of gene expression data from human and mouse breast cancers: Identification of a conserved breast tumor gene set , 2007, International journal of cancer.

[15]  Ryan E. Mills,et al.  Classical Nuclear Localization Signals: Definition, Function, and Interaction with Importin α* , 2007, Journal of Biological Chemistry.

[16]  Wen-Lin Kuo,et al.  A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. , 2006, Cancer cell.

[17]  Christian Pilarsky,et al.  Molecular Profiling of Laser-Microdissected Matched Tumor and Normal Breast Tissue Identifies Karyopherin α2 as a Potential Novel Prognostic Marker in Breast Cancer , 2006, Clinical Cancer Research.

[18]  A. Clark,et al.  Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma , 2005, Cancer.

[19]  Yukinori Endo,et al.  A Rac switch regulates random versus directionally persistent cell migration , 2005, The Journal of cell biology.

[20]  S. Gelling,et al.  Systematic identification and molecular characterization of genes differentially expressed in breast and ovarian cancer , 2005, The Journal of pathology.

[21]  L. Pemberton,et al.  Karyopherins: from nuclear-transport mediators to nuclear-function regulators. , 2004, Trends in cell biology.

[22]  D. Goldfarb,et al.  Importin α: A multipurpose nuclear-transport receptor , 2004 .

[23]  Pamela A. Silver,et al.  Nuclear transport and cancer: from mechanism to intervention , 2004, Nature Reviews Cancer.

[24]  G. Borisy,et al.  Cell Migration: Integrating Signals from Front to Back , 2003, Science.

[25]  R. Tibshirani,et al.  Repeated observation of breast tumor subtypes in independent gene expression data sets , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[26]  M. Hodel,et al.  Characterization of the Auto-inhibitory Sequence within the N-terminal Domain of Importin α* , 2003, Journal of Biological Chemistry.

[27]  S. Nadler,et al.  An intracellular targeted NLS peptide inhibitor of karyopherin α:NF-κB interactions , 2003 .

[28]  Michael Karin,et al.  NF-κB in cancer: from innocent bystander to major culprit , 2002, Nature Reviews Cancer.

[29]  L. Thiberville,et al.  Inhibition of tumor growth and metastatic spreading by overexpression of inter‐alpha‐trypsin inhibitor family chains , 2002, International journal of cancer.

[30]  G. Blobel,et al.  Karyopherins and nuclear import. , 2001, Current opinion in structural biology.

[31]  G. Christofori,et al.  Cell adhesion in tumor invasion and metastasis: loss of the glue is not enough. , 2001, Biochimica et biophysica acta.

[32]  D. Helfman,et al.  Cytoskeletal changes in cell transformation and tumorigenesis. , 2001, Current opinion in genetics & development.

[33]  Christian A. Rees,et al.  Molecular portraits of human breast tumours , 2000, Nature.

[34]  Jiandong Chen,et al.  Nuclear exclusion of p53 in a subset of tumors requires MDM2 function , 2000, Oncogene.

[35]  B. Rayet,et al.  Aberrant rel/nfkb genes and activity in human cancer , 1999, Oncogene.

[36]  D. Görlich Transport into and out of the cell nucleus , 1998, The EMBO journal.

[37]  G. Curigliano,et al.  Prognostic significance of cytoplasmic p53 overexpression in colorectal cancer. An immunohistochemical analysis. , 1996, European journal of cancer.

[38]  R. Kreienberg,et al.  Subcellular localization of accumulated p53 in ovarian cancer cells. , 1996, Gynecologic oncology.

[39]  D. Lauffenburger,et al.  Cell Migration: A Physically Integrated Molecular Process , 1996, Cell.

[40]  A. Ashworth,et al.  An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1 , 1995, Science.

[41]  G. Blobel,et al.  The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex , 1995, Cell.

[42]  D. Lane,et al.  Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some, neoplasms , 1990, The Journal of pathology.

[43]  H. Kuwano,et al.  Significance of karyopherin-{alpha} 2 (KPNA2) expression in esophageal squamous cell carcinoma. , 2010, Anticancer research.

[44]  A. Hall,et al.  Cell migration: Rho GTPases lead the way. , 2004, Developmental biology.

[45]  D. Goldfarb,et al.  Importin alpha: a multipurpose nuclear-transport receptor. , 2004, Trends in cell biology.

[46]  S. Nadler,et al.  An intracellular targeted NLS peptide inhibitor of karyopherin alpha:NF-kappa B interactions. , 2003, Biochemical and biophysical research communications.

[47]  Michael Karin,et al.  NF-kappaB in cancer: from innocent bystander to major culprit. , 2002, Nature reviews. Cancer.

[48]  A. Brunet,et al.  [MAP kinase module: role in the control of cell proliferation]. , 1995, Comptes rendus des seances de la Societe de biologie et de ses filiales.