Exploration of DNA Nanostructures for Rational Design of Vaccines

[1]  Chunhai Fan,et al.  Growth and origami folding of DNA on nanoparticles for high-efficiency molecular transport in cellular imaging and drug delivery. , 2015, Angewandte Chemie.

[2]  B. Verrier,et al.  Poly(lactic acid) and poly(lactic-co-glycolic acid) particles as versatile carrier platforms for vaccine delivery. , 2014, Nanomedicine.

[3]  G. Barber,et al.  The STING controlled cytosolic-DNA activated innate immune pathway and microbial disease. , 2014, Microbes and infection.

[4]  Ying Wang,et al.  STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. , 2014, Immunity.

[5]  T. McGaha,et al.  Cytosolic DNA sensing via the stimulator of interferon genes adaptor: Yin and Yang of immune responses to DNA , 2014, European journal of immunology.

[6]  William M. Shih,et al.  Addressing the Instability of DNA Nanostructures in Tissue Culture , 2014, ACS nano.

[7]  Jiye Shi,et al.  Single-particle tracking and modulation of cell entry pathways of a tetrahedral DNA nanostructure in live cells. , 2014, Angewandte Chemie.

[8]  T. Hanke,et al.  Safety and Tolerability of Conserved Region Vaccines Vectored by Plasmid DNA, Simian Adenovirus and Modified Vaccinia Virus Ankara Administered to Human Immunodeficiency Virus Type 1-Uninfected Adults in a Randomized, Single-Blind Phase I Trial , 2014, PloS one.

[9]  M. Carroll,et al.  Follicular dendritic cells: dynamic antigen libraries , 2014, Nature Reviews Immunology.

[10]  Qiao Jiang,et al.  DNA origami as an in vivo drug delivery vehicle for cancer therapy. , 2014, ACS nano.

[11]  Hailong Meng,et al.  CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype , 2014, Nature Immunology.

[12]  M. Slifka,et al.  How advances in immunology provide insight into improving vaccine efficacy. , 2014, Vaccine.

[13]  Dongsheng Liu,et al.  DNA nanotechnology based on i-motif structures. , 2014, Accounts of chemical research.

[14]  C. Fraser,et al.  Generation of a universal CD4 memory T cell recall peptide effective in humans, mice and non-human primates. , 2014, Vaccine.

[15]  Jonathan L. Schmid-Burgk,et al.  TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner , 2014, The Journal of Immunology.

[16]  Yuki Takahashi,et al.  Injectable, self-gelling, biodegradable, and immunomodulatory DNA hydrogel for antigen delivery. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[17]  Joel H Collier,et al.  Engaging adaptive immunity with biomaterials. , 2014, Journal of materials chemistry. B.

[18]  H. Bermudez,et al.  Design and application of multifunctional DNA nanocarriers for therapeutic delivery. , 2014, Acta biomaterialia.

[19]  Zhijian J. Chen,et al.  Innate immune sensing and signaling of cytosolic nucleic acids. , 2014, Annual review of immunology.

[20]  P. Blomberg,et al.  Safety and efficacy of DNA vaccines , 2014, Human vaccines & immunotherapeutics.

[21]  Chenming Zhang,et al.  A novel and efficient nicotine vaccine using nano-lipoplex as a delivery vehicle , 2014, Human vaccines & immunotherapeutics.

[22]  Darrell J Irvine,et al.  Engineering synthetic vaccines using cues from natural immunity. , 2013, Nature materials.

[23]  Zhijian J. Chen,et al.  Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects , 2013, Science.

[24]  D. Tarlinton,et al.  Diversity Among Memory B Cells: Origin, Consequences, and Utility , 2013, Science.

[25]  Jiye Shi,et al.  Smart Drug Delivery Nanocarriers with Self‐Assembled DNA Nanostructures , 2013, Advanced materials.

[26]  Douglas M. Smith,et al.  Applications of nanotechnology for immunology , 2013, Nature Reviews Immunology.

[27]  G. Barber,et al.  STING recognition of cytoplasmic DNA instigates cellular defense. , 2013, Molecular cell.

[28]  Anthony E. Gregory,et al.  Vaccine delivery using nanoparticles , 2013, Front. Cell. Infect. Microbiol..

[29]  Hao Yan,et al.  DNA Gridiron Nanostructures Based on Four-Arm Junctions , 2013, Science.

[30]  D. Munn,et al.  Indoleamine 2,3 dioxygenase and metabolic control of immune responses. , 2013, Trends in immunology.

[31]  K. Janda,et al.  Enhancing nicotine vaccine immunogenicity with liposomes. , 2013, Bioorganic & medicinal chemistry letters.

[32]  Zhijian J. Chen,et al.  Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA , 2013, Science.

[33]  Ick Chan Kwon,et al.  Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells. , 2013, Chemical communications.

[34]  Michael Famulok,et al.  I-motif-programmed functionalization of DNA nanocircles. , 2013, Journal of the American Chemical Society.

[35]  T. Liedl,et al.  Nucleic acid nanostructures for biomedical applications. , 2013, Nanomedicine.

[36]  M. Jenkins,et al.  Heterogeneity in the differentiation and function of memory B cells. , 2012, Trends in immunology.

[37]  G. Barber,et al.  STING manifests self DNA-dependent inflammatory disease , 2012, Proceedings of the National Academy of Sciences.

[38]  Hao Yan,et al.  Robust DNA-functionalized core/shell quantum dots with fluorescent emission spanning from UV-vis to near-IR and compatible with DNA-directed self-assembly. , 2012, Journal of the American Chemical Society.

[39]  Y. Takakura,et al.  Self-assembling CpG DNA nanoparticles for efficient antigen delivery and immunostimulation. , 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[40]  Jeffrey A Hubbell,et al.  Engineering Approaches to Immunotherapy , 2012, Science Translational Medicine.

[41]  Hao Yan,et al.  A DNA nanostructure platform for directed assembly of synthetic vaccines. , 2012, Nano letters.

[42]  Hao Yan,et al.  DNA origami as a carrier for circumvention of drug resistance. , 2012, Journal of the American Chemical Society.

[43]  K. Ishii,et al.  Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination , 2012, Nature Reviews Immunology.

[44]  Tomoki Shiomi,et al.  Design and development of nanosized DNA assemblies in polypod-like structures as efficient vehicles for immunostimulatory CpG motifs to immune cells. , 2012, ACS nano.

[45]  Daniel G. Anderson,et al.  Molecularly Self-Assembled Nucleic Acid Nanoparticles for Targeted In Vivo siRNA Delivery , 2012, Nature nanotechnology.

[46]  M. Bachmann,et al.  Innate Immunity Mediates Follicular Transport of Particulate but Not Soluble Protein Antigen , 2012, The Journal of Immunology.

[47]  Wen Jiang,et al.  DNA-directed three-dimensional protein organization. , 2012, Angewandte Chemie.

[48]  D. Rawlings,et al.  Integration of B cell responses through Toll-like receptors and antigen receptors , 2012, Nature Reviews Immunology.

[49]  D. Choubey DNA-responsive inflammasomes and their regulators in autoimmunity. , 2012, Clinical immunology.

[50]  Dongsheng Liu,et al.  DNA pillars constructed from an i-motif stem and duplex branches. , 2012, Small.

[51]  D. Irvine,et al.  Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction , 2012, Proceedings of the National Academy of Sciences.

[52]  Nathaniel S Wang,et al.  Molecular programming of B cell memory , 2011, Nature Reviews Immunology.

[53]  T. Clay,et al.  CpG Oligodeoxynucleotides as TLR9 Agonists , 2012, BioDrugs.

[54]  Jin-Ho Ahn,et al.  Design, assembly, and activity of antisense DNA nanostructures. , 2011, Small.

[55]  Hao Yan,et al.  Challenges and opportunities for structural DNA nanotechnology. , 2011, Nature nanotechnology.

[56]  Tim Liedl,et al.  Cellular immunostimulation by CpG-sequence-coated DNA origami structures. , 2011, ACS nano.

[57]  H. Pei,et al.  Self-assembled multivalent DNA nanostructures for noninvasive intracellular delivery of immunostimulatory CpG oligonucleotides. , 2011, ACS nano.

[58]  D. Irvine,et al.  In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles , 2011, Proceedings of the National Academy of Sciences.

[59]  G. Barber Cytoplasmic DNA innate immune pathways , 2011, Immunological Reviews.

[60]  Hao Yan,et al.  Targeted cell-cell interactions by DNA nanoscaffold-templated multivalent bispecific aptamers. , 2011, Small.

[61]  Hao Yan,et al.  DNA Origami with Complex Curvatures in Three-Dimensional Space , 2011, Science.

[62]  R. Maul,et al.  Different B Cell Populations Mediate Early and Late Memory During an Endogenous Immune Response , 2011, Science.

[63]  D. Meldrum,et al.  Stability of DNA origami nanoarrays in cell lysate. , 2011, Nano letters.

[64]  Hao Yan,et al.  Encapsulation of gold nanoparticles in a DNA origami cage. , 2011, Angewandte Chemie.

[65]  S. Akira,et al.  Pathogen Recognition by the Innate Immune System , 2011, International reviews of immunology.

[66]  John Steel,et al.  Programming the magnitude and persistence of antibody responses with innate immunity , 2010, Nature.

[67]  Dan Luo,et al.  Biodegradable CpG DNA hydrogels for sustained delivery of doxorubicin and immunostimulatory signals in tumor-bearing mice. , 2011, Biomaterials.

[68]  Martin F. Bachmann,et al.  Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns , 2010, Nature Reviews Immunology.

[69]  Hao Yan,et al.  Folding and cutting DNA into reconfigurable topological nanostructures. , 2010, Nature nanotechnology.

[70]  R. Noelle,et al.  The immortality of humoral immunity , 2010, Immunological reviews.

[71]  N. Seeman Nanomaterials based on DNA. , 2010, Annual review of biochemistry.

[72]  Y. Takakura,et al.  DNA-based nano-sized systems for pharmaceutical and biomedical applications. , 2010, Advanced drug delivery reviews.

[73]  Dan Luo,et al.  DNA nanomedicine: Engineering DNA as a polymer for therapeutic and diagnostic applications☆ , 2010, Advanced Drug Delivery Reviews.

[74]  Jung-Won Keum,et al.  Enhanced resistance of DNA nanostructures to enzymatic digestion. , 2009, Chemical communications.

[75]  Shawn M. Douglas,et al.  Folding DNA into Twisted and Curved Nanoscale Shapes , 2009, Science.

[76]  D. Muruve,et al.  The innate immune response to DNA. , 2009, Seminars in immunology.

[77]  Adam H. Marblestone,et al.  Rapid prototyping of 3D DNA-origami shapes with caDNAno , 2009, Nucleic acids research.

[78]  Shawn M. Douglas,et al.  Self-assembly of DNA into nanoscale three-dimensional shapes , 2009, Nature.

[79]  A. Krieg,et al.  Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists. , 2009, Advanced drug delivery reviews.

[80]  Hao Yan,et al.  Designer DNA nanoarchitectures. , 2009, Biochemistry.

[81]  Hao Yan,et al.  Tiamat: A Three-Dimensional Editing Tool for Complex DNA Structures , 2009, DNA.

[82]  Hao Yan,et al.  Self-assembled DNA nanostructures for distance-dependent multivalent ligand-protein binding. , 2008, Nature nanotechnology.

[83]  Hao Yan,et al.  Self-Assembled Water-Soluble Nucleic Acid Probe Tiles for Label-Free RNA Hybridization Assays , 2008, Science.

[84]  P. Puccetti On watching the watchers: IDO and type I/II IFN , 2007, European journal of immunology.

[85]  K. Ishii,et al.  Innate immune recognition of, and regulation by, DNA. , 2006, Trends in immunology.

[86]  Hao Yan,et al.  Self-assembled signaling aptamer DNA arrays for protein detection. , 2006, Angewandte Chemie.

[87]  P. Rothemund Folding DNA to create nanoscale shapes and patterns , 2006, Nature.

[88]  H. Yoshida,et al.  Lethal anemia caused by interferon-β produced in mouse embryos carrying undigested DNA , 2005, Nature Immunology.

[89]  K. Yasutomo,et al.  DNaseI in pathogenesis of systemic lupus erythematosus. , 2004, Clinical immunology.

[90]  B. Monks,et al.  TLR9 signals after translocating from the ER to CpG DNA in the lysosome , 2004, Nature Immunology.

[91]  Yan Liu,et al.  DNA-Templated Self-Assembly of Protein Arrays and Highly Conductive Nanowires , 2003, Science.

[92]  U. Grohmann,et al.  Tolerance, DCs and tryptophan: much ado about IDO. , 2003, Trends in immunology.

[93]  N. Seeman DNA in a material world , 2003, Nature.

[94]  N. Seeman Nucleic acid junctions and lattices. , 1982, Journal of theoretical biology.