Cell signalling pathways interaction in cellular proliferation: Potential target for therapeutic interventionism

Abstract Nowadays, cellular physiology is best understood by analysing their interacting molecular components. Proteins are the major components of the cells. Different proteins are organised in the form of functional clusters, pathways or networks. These molecules are ordered in clusters of receptor molecules of extracellular signals, transducers, sensors and biological response effectors. The identification of these intracellular signalling pathways in different cellular types has required a long journey of experimental work. More than 300 intracellular signalling pathways have been identified in human cells. They participate in cell homeostasis processes for structural and functional maintenance. Some of them participate simultaneously or in a nearly consecutive progression to generate a cellular phenotypic change. In this review, an analysis is performed on the main intracellular signalling pathways that take part in the cellular proliferation process, and the potential use of some components of these pathways as target for therapeutic interventionism are also underlined.

[1]  Carles Zafón,et al.  [The mitogen-activated protein kinase (MAPK) signaling pathway in papillary thyroid cancer. From the molecular bases to clinical practice]. , 2009, Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion.

[2]  D. Morrison,et al.  MAP kinase pathways. , 2012, Cold Spring Harbor perspectives in biology.

[3]  A. Grzanka,et al.  [Involvement of Rho proteins in G1 phase cell cycle progression]. , 2013, Postepy higieny i medycyny doswiadczalnej.

[4]  Marco Foiani,et al.  Regulation of DNA repair throughout the cell cycle , 2008, Nature Reviews Molecular Cell Biology.

[5]  A. Cataldi,et al.  Cyclin-Dependent Kinase Modulators and Cancer Therapy , 2012, BioDrugs.

[6]  L. Fajas.  Re-thinking cell cycle regulators: the cross-talk with metabolism , 2013, Front. Oncol..

[7]  P. Ward,et al.  Signaling in control of cell growth and metabolism. , 2012, Cold Spring Harbor perspectives in biology.

[8]  J. Decaprio,et al.  The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression. , 2012, Genes & development.

[9]  J. Summerton,et al.  Morpholino, siRNA, and S-DNA compared: impact of structure and mechanism of action on off-target effects and sequence specificity. , 2007, Current topics in medicinal chemistry.

[10]  Yue Xiong,et al.  Signaling pathways that control cell proliferation. , 2013, Cold Spring Harbor perspectives in biology.

[11]  Rony Seger,et al.  The MAP kinase signaling cascades: a system of hundreds of components regulates a diverse array of physiological functions. , 2010, Methods in molecular biology.

[12]  Chris T. A. Evelo,et al.  WikiPathways: building research communities on biological pathways , 2011, Nucleic Acids Res..

[13]  Lei Li,et al.  Sensing, signaling, and responding to DNA damage: Organization of the checkpoint pathways in mammalian cells , 2005, Journal of cellular biochemistry.

[14]  Susumu Goto,et al.  The KEGG resource for deciphering the genome , 2004, Nucleic Acids Res..

[15]  C. Sander,et al.  Mutual exclusivity analysis identifies oncogenic network modules. , 2012, Genome research.

[16]  F. Trimarchi,et al.  Genetic alterations in the RAS/RAF/mitogen‐activated protein kinase and phosphatidylinositol 3‐kinase/Akt signaling pathways in the follicular variant of papillary thyroid carcinoma , 2010, Cancer.

[17]  J. Bertoglio,et al.  Cell cycle regulation of Rho signaling pathways , 2012, Cell cycle.

[18]  Fei Tan,et al.  The elements of human cyclin D1 promoter and regulation involved , 2011, Clinical Epigenetics.

[19]  J. Sáez.  Treatment directed to signalling molecules in patients with advanced differentiated thyroid cancer. , 2013, Anti-cancer agents in medicinal chemistry.

[20]  Gary D. Bader,et al.  Pathguide: a Pathway Resource List , 2005, Nucleic Acids Res..

[21]  Tony Pawson,et al.  Signalling change: signal transduction through the decades , 2013, Nature Reviews Molecular Cell Biology.

[22]  Wendell A. Lim,et al.  Designing customized cell signalling circuits , 2010, Nature Reviews Molecular Cell Biology.

[23]  Birgit Eisenhaber,et al.  Biomolecular pathway databases. , 2010, Methods in molecular biology.

[24]  B. Cuevas,et al.  Role of mitogen-activated protein kinase kinase kinases in signal integration , 2007, Oncogene.

[25]  Rony Seger,et al.  The MEK/ERK cascade: from signaling specificity to diverse functions. , 2007, Biochimica et biophysica acta.

[26]  F. Marelli-Berg,et al.  Molecular mechanisms of metabolic reprogramming in proliferating cells: implications for T‐cell‐mediated immunity , 2012, Immunology.

[27]  P. Ray,et al.  Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. , 2012, Cellular signalling.