Preclinical modeling of myelodysplastic syndromes

[1]  J. Gribben,et al.  Versatile humanized niche model enables study of normal and malignant human hematopoiesis , 2017, The Journal of clinical investigation.

[2]  G. Mufti,et al.  Myelodysplastic syndrome can propagate from the multipotent progenitor compartment , 2017, Haematologica.

[3]  A. Reinisch,et al.  A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells , 2016, Nature Medicine.

[4]  A. Tefferi,et al.  Myelodysplastic syndromes: Contemporary review and how we treat , 2016, American journal of hematology.

[5]  G. Mufti,et al.  SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment , 2015, Nature Communications.

[6]  S. Linnarsson,et al.  Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo. , 2014, Cancer cell.

[7]  M. Wunderlich,et al.  OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues. , 2014, Blood.

[8]  A. Trumpp,et al.  Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit. , 2014, Cell stem cell.

[9]  C Haferlach,et al.  Landscape of genetic lesions in 944 patients with myelodysplastic syndromes , 2013, Leukemia.

[10]  H. Deeg,et al.  Murine xenogeneic models of myelodysplastic syndrome: an essential role for stroma cells. , 2014, Experimental hematology.

[11]  I. Bruns,et al.  Insufficient stromal support in MDS results from molecular and functional deficits of mesenchymal stromal cells , 2013, Leukemia.

[12]  G. Mufti,et al.  Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome , 2013, Haematologica.

[13]  Luca Malcovati,et al.  Revised international prognostic scoring system for myelodysplastic syndromes. , 2012, Blood.

[14]  M. Stratton,et al.  Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. , 2011, The New England journal of medicine.

[15]  S. Sugano,et al.  Frequent pathway mutations of splicing machinery in myelodysplasia , 2011, Nature.

[16]  B. Bain,et al.  Diagnosis and classification of myelodysplastic syndrome: International Working Group on Morphology of myelodysplastic syndrome (IWGM-MDS) consensus proposals for the definition and enumeration of myeloblasts and ring sideroblasts , 2008, Haematologica.