Mechanisms underlying hypoxia-induced neuronal apoptosis

[1]  Philippe P Roux,et al.  p75 Neurotrophin Receptor Expression Is Induced in Apoptotic Neurons After Seizure , 1999, The Journal of Neuroscience.

[2]  G. Lundborg,et al.  Vascular Endothelial Growth Factor Has Neurotrophic Activity and Stimulates Axonal Outgrowth, Enhancing Cell Survival and Schwann Cell Proliferation in the Peripheral Nervous System , 1999, The Journal of Neuroscience.

[3]  A. Nitta,et al.  Brain‐derived neurotrophic factor prevents neuronal cell death induced by corticosterone , 1999, Journal of neuroscience research.

[4]  B. Sola,et al.  Reduction of Ischemic Damage in NGF-Transgenic Mice: Correlation with Enhancement of Antioxidant Enzyme Activities , 1999, Neurobiology of Disease.

[5]  W. R. Epa,et al.  Nerve Growth Factor Determines Survival and Death of PC12 Cells by Regulation of the bcl‐x, bax, and caspase‐3 Genes , 1999, Journal of neurochemistry.

[6]  G. Khursigara,et al.  p75 neurotrophin receptor as a modulator of survival and death decisions , 1999, Microscopy research and technique.

[7]  L. Ellerby,et al.  Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[8]  X. Wang,et al.  Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45 , 1999, Oncogene.

[9]  D. Allen,et al.  Changes in intracellular Na+ and pH in rat heart during ischemia: role of Na+/H+ exchanger. , 1999, The American journal of physiology.

[10]  D. Choi,et al.  NMDA receptor-mediated K+ efflux and neuronal apoptosis. , 1999, Science.

[11]  M. Dragunow,et al.  Neuronal death and survival in two models of hypoxic-ischemic brain damage , 1999, Brain Research Reviews.

[12]  C. Harris,et al.  GADD45 induction of a G2/M cell cycle checkpoint. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[13]  B. Corfe,et al.  Cell Damage-induced Conformational Changes of the Pro-Apoptotic Protein Bak In Vivo Precede the Onset of Apoptosis , 1999, The Journal of cell biology.

[14]  Jun-Sub Choi,et al.  Necrosis and apoptosis after retinal ischemia: involvement of NMDA-mediated excitotoxicity and p53. , 1999, Investigative ophthalmology & visual science.

[15]  M. Paiva,et al.  BDNF and NGF Afford in vitro Neuroprotection against Ethanol Combined with Acute Ischemia and Chronic Hypoglycemia , 1999, Developmental Neuroscience.

[16]  P. Gluckman,et al.  Activity and injury-dependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous system , 1999, Progress in Neurobiology.

[17]  Y. Tan,et al.  Biophysical characterization of the oligomeric state of Bax and its complex formation with Bcl-XL. , 1999, Biochemical and biophysical research communications.

[18]  J. Pickard,et al.  Delayed induction of JunB precedes CA1 neuronal death after global ischemia in the gerbil , 1999, Brain Research.

[19]  L Manzo,et al.  Neuronal cell death: a demise with different shapes. , 1999, Trends in pharmacological sciences.

[20]  M. Priault,et al.  Role of the C‐terminal domain of Bax and Bcl‐xL in their localization and function in yeast cells , 1999, FEBS letters.

[21]  S. Korsmeyer,et al.  Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death* , 1999, The Journal of Biological Chemistry.

[22]  Y. Nomura,et al.  A transient brain ischemia- and bacterial endotoxin-induced glial iNOS expression and NO-induced neuronal apoptosis. , 1998, Toxicology letters.

[23]  W. Risau,et al.  Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptors. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[24]  A. Berns,et al.  A link between cell cycle and cell death: Bax and Bcl‐2 modulate Cdk2 activation during thymocyte apoptosis , 1998, The EMBO journal.

[25]  T. Chittenden,et al.  Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[26]  M Al-Rubeai,et al.  Use of intracellular pH and annexin-V flow cytometric assays to monitor apoptosis and its suppression by bcl-2 over-expression in hybridoma cell culture. , 1998, Journal of immunological methods.

[27]  M. Mattson,et al.  Ischemic and Excitotoxic Brain Injury is Enhanced in Mice Lacking the p55 Tumor Necrosis Factor Receptor , 1998, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[28]  H. Zhang,et al.  Redistribution of Bax from cytosol to membranes is induced by apoptotic stimuli and is an early step in the apoptotic pathway. , 1998, Biochemical and biophysical research communications.

[29]  H. Kim,et al.  Modulation of endoplasmic reticulum calcium pump by Bcl-2 , 1998, Oncogene.

[30]  S. Korsmeyer,et al.  Regulated Targeting of BAX to Mitochondria , 1998, The Journal of cell biology.

[31]  D. Hall,et al.  The role of the p53 protein in the selective vulnerability of the inner retina to transient ischemia. , 1998, Investigative ophthalmology & visual science.

[32]  A. Giaccia,et al.  The complexity of p53 modulation: emerging patterns from divergent signals. , 1998, Genes & development.

[33]  I. Ceballos-Picot,et al.  Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: relevance to Parkinson's disease. , 1998, Biochemical pharmacology.

[34]  A. Hsueh,et al.  BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. , 1998, Molecular endocrinology.

[35]  S. Lipton,et al.  Role of Caspases in N‐Methyl‐d‐Aspartate‐Induced Apoptosis in Cerebrocortical Neurons , 1998, Journal of neurochemistry.

[36]  Xiaodong Wang,et al.  Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors , 1998, Cell.

[37]  Junying Yuan,et al.  Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis , 1998, Cell.

[38]  B. Attali,et al.  Constitutive activation of delayed‐rectifier potassium channels by a Src family tyrosine kinase in Schwann cells , 1998, The EMBO journal.

[39]  M. Montal,et al.  Mitochondria, glutamate neurotoxicity and the death cascade. , 1998, Biochimica et biophysica acta.

[40]  Guo-Yuan Yang,et al.  Cellular localization of tumor necrosis factor alpha following focal cerebral ischemia in mice , 1998, Brain Research.

[41]  J L Cleveland,et al.  Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. , 1998, Genes & development.

[42]  Chen-Hsiung Yeh,et al.  Enhancement of Outward Potassium Current May Participate in β-Amyloid Peptide-Induced Cortical Neuronal Death , 1998, Neurobiology of Disease.

[43]  M. Tohyama,et al.  Roles of Bcl-2 and caspases in hypoxia-induced neuronal cell death: a possible neuroprotective mechanism of peptide growth factors. , 1998, Brain research. Molecular brain research.

[44]  S. Korsmeyer,et al.  Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis , 1998, The EMBO journal.

[45]  L. Oliver,et al.  Induction of a Caspase-3-like Activity by Calcium in Normal Cytosolic Extracts Triggers Nuclear Apoptosis in a Cell-free System* , 1998, The Journal of Biological Chemistry.

[46]  G. Núñez,et al.  Regulation of Bcl-xl Channel Activity by Calcium* , 1998, The Journal of Biological Chemistry.

[47]  K. Vousden,et al.  Characterization of Structural p53 Mutants Which Show Selective Defects in Apoptosis but Not Cell Cycle Arrest , 1998, Molecular and Cellular Biology.

[48]  Kevin K W Wang,et al.  Evidence for Activation of Caspase‐3‐Like Protease in Excitotoxin‐ and Hypoxia/Hypoglycemia‐Injured Neurons , 1998, Journal of neurochemistry.

[49]  R. Simon,et al.  Induction of Caspase-3-Like Protease May Mediate Delayed Neuronal Death in the Hippocampus after Transient Cerebral Ischemia , 1998, The Journal of Neuroscience.

[50]  J. Baudier,et al.  Calcium and S100B Regulation of p53-Dependent Cell Growth Arrest and Apoptosis , 1998, Molecular and Cellular Biology.

[51]  H. Perlman,et al.  Bax‐mediated cell death by the Gax homeoprotein requires mitogen activation but is independent of cell cycle activity , 1998, The EMBO journal.

[52]  A. Giaccia,et al.  Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress. , 1998, Genes & development.

[53]  M. Scheid,et al.  Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[54]  P. Maher,et al.  The Regulation of Reactive Oxygen Species Production during Programmed Cell Death , 1998, The Journal of cell biology.

[55]  D. Bredesen,et al.  Bcl‐2 Protects Against Apoptosis in Neuronal Cell Line Caused by Thapsigargin‐Induced Depletion of Intracellular Calcium Stores , 1998, Journal of neurochemistry.

[56]  W. Kaiser,et al.  Inhibitor of Apoptosis Proteins Physically Interact with and Block Apoptosis Induced by Drosophila Proteins HID and GRIM , 1998, Molecular and Cellular Biology.

[57]  R. Simon,et al.  Transient Global Ischemia Triggers Expression of the DNA Damage-Inducible Gene GADD45 in the Rat Brain , 1998, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[58]  M. Moskowitz,et al.  Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia , 1998, The Journal of Neuroscience.

[59]  S. Demo,et al.  A Novel Splice Variant of the Cell Death-promoting Protein BAX* , 1998, The Journal of Biological Chemistry.

[60]  L. Colom,et al.  Role of Potassium Channels in Amyloid‐Induced Cell Death , 1998, Journal of neurochemistry.

[61]  G. Kroemer,et al.  Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins , 1998, Oncogene.

[62]  Yuanming Hu,et al.  Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[63]  G. Núñez,et al.  Mtd, a Novel Bcl-2 Family Member Activates Apoptosis in the Absence of Heterodimerization with Bcl-2 and Bcl-XL * , 1998, The Journal of Biological Chemistry.

[64]  Ken Chen,et al.  The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53 , 1998, Cell.

[65]  D. Goeddel,et al.  FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. , 1998, Science.

[66]  Yue Xiong,et al.  ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways , 1998, Cell.

[67]  V. Dixit,et al.  Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex* , 1998, The Journal of Biological Chemistry.

[68]  D. Chuang,et al.  Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[69]  M. Collins,et al.  Induction of apoptosis by valinomycin: mitochondrial permeability transition causes intracellular acidification , 1998, Cell Death and Differentiation.

[70]  G. Haddad,et al.  Differential Effects of Anoxia and Glutamate on Cultured Neocortical Neurons , 1998, Experimental Neurology.

[71]  G. Shore,et al.  Bcl-XL Cooperatively Associates with the Bap31 Complex in the Endoplasmic Reticulum, Dependent on Procaspase-8 and Ced-4 Adaptor* , 1998, The Journal of Biological Chemistry.

[72]  M. Mattson,et al.  Calcium and reactive oxygen species mediate staurosporine‐induced mitochondrial dysfunction and apoptosis in PC12 cells , 1998, Journal of neuroscience research.

[73]  John Calvin Reed,et al.  The Mitochondrial F0F1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells. , 1998, Molecular cell.

[74]  D. Bristow,et al.  N‐Methyl‐d‐Aspartate Receptor Desensitisation Is Neuroprotective by Inhibiting Glutamate‐Induced Apoptotic‐Like Death , 1998, Journal of neurochemistry.

[75]  John Calvin Reed,et al.  Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. , 1998, Molecular cell.

[76]  H. Ogura,et al.  Apoptotic Cell Death of Cultured Cerebral Cortical Neurons Induced by Withdrawal of Astroglial Trophic Support , 1998, Experimental Neurology.

[77]  Brent R. Stockwell,et al.  An Induced Proximity Model for Caspase-8 Activation* , 1998, The Journal of Biological Chemistry.

[78]  D G Kirsch,et al.  Modulation of cell death by Bcl-XL through caspase interaction. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[79]  A. Strasser,et al.  Bim: a novel member of the Bcl‐2 family that promotes apoptosis , 1998, The EMBO journal.

[80]  A. Levine,et al.  Nucleo‐cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein , 1998, The EMBO journal.

[81]  M. Memo,et al.  Induction of tumour‐suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids , 1998, The European journal of neuroscience.

[82]  B. Zlokovic,et al.  Circulating Antibody against Tumor Necrosis Factor–Alpha Protects Rat Brain from Reperfusion Injury , 1998, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[83]  John Calvin Reed,et al.  Differential Regulation of Bax, Bcl‐2, and Bcl‐X Proteins in Focal Cortical Ischemia in the Rat , 1998, Brain pathology.

[84]  D. Choi,et al.  Caspase Inhibition Selectively Reduces the Apoptotic Component of Oxygen-Glucose Deprivation-Induced Cortical Neuronal Cell Death , 1997, Molecular and Cellular Neuroscience.

[85]  John Calvin Reed,et al.  Heterodimerization-independent Functions of Cell Death Regulatory Proteins Bax and Bcl-2 in Yeast and Mammalian Cells* , 1997, The Journal of Biological Chemistry.

[86]  A. Hara,et al.  Expression of Bax and Bcl-2 protein in the gerbil hippocampus following transient forebrain ischemia and its modification by phencyclidine. , 1997, Neurological research.

[87]  P. Clarke,et al.  Regulation of apoptosis by BH3 domains in a cell-free system , 1997, Current Biology.

[88]  M. V. Heiden,et al.  Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria , 1997, Cell.

[89]  H. Horvitz,et al.  Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor , 1997, Nature.

[90]  S. Srinivasula,et al.  Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade , 1997, Cell.

[91]  A. Hsueh,et al.  Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[92]  P. Nicotera,et al.  Caspase-Mediated Apoptosis in Neuronal Excitotoxicity Triggered by Nitric Oxide , 1997, Molecular medicine.

[93]  J. Hurwitz,et al.  The large subunit of replication factor C is a substrate for caspase‐3 in vitro and is cleaved by a caspase‐3‐like protease during Fas‐mediated apoptosis , 1997, The EMBO journal.

[94]  K. Tracey,et al.  TUMOR NECROSIS FACTOR IS A BRAIN DAMAGING CYTOKINE IN CEREBRAL ISCHEMIA , 1997, Shock.

[95]  M. Karmazyn,et al.  A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide). , 1997, Journal of molecular and cellular cardiology.

[96]  Yoichi Taya,et al.  DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2 , 1997, Cell.

[97]  P. Branton,et al.  p28 Bap31, a Bcl-2/Bcl-XL- and Procaspase-8–associated Protein in the Endoplasmic Reticulum , 1997, The Journal of cell biology.

[98]  G Waksman,et al.  Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[99]  Jay X. Tang,et al.  Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. , 1997, Science.

[100]  G. Rosen,et al.  Cleavage of Focal Adhesion Kinase by Caspases during Apoptosis* , 1997, The Journal of Biological Chemistry.

[101]  D. Choi,et al.  Mediation of neuronal apoptosis by enhancement of outward potassium current. , 1997, Science.

[102]  P. Hainaut,et al.  Regulation of p53 by metal ions and by antioxidants: dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper , 1997, Molecular and cellular biology.

[103]  W. Earnshaw,et al.  Caspases and caspase inhibitors. , 1997, Trends in biochemical sciences.

[104]  M. Simonen,et al.  The BH3 domain of Bax is sufficient for interaction of Bax with itself and with other family members and it is required for induction of apoptosis. , 1997, European journal of biochemistry.

[105]  S. Korsmeyer,et al.  BH3 Domain of BAD Is Required for Heterodimerization with BCL-XL and Pro-apoptotic Activity* , 1997, The Journal of Biological Chemistry.

[106]  B. Chaudhuri,et al.  Release of cytochrome c and decrease of cytochrome c oxidase in Bax‐expressing yeast cells, and prevention of these effects by coexpression of Bcl‐xL , 1997, FEBS letters.

[107]  D. Lane,et al.  p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding , 1997, Oncogene.

[108]  S. Berger,et al.  CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein. , 1997, Cancer research.

[109]  Wei Gu,et al.  Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain , 1997, Cell.

[110]  W I Wood,et al.  Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. , 1997, Science.

[111]  R. Gentz,et al.  An antagonist decoy receptor and a death domain-containing receptor for TRAIL. , 1997, Science.

[112]  N. Thornberry,et al.  Caspases: killer proteases. , 1997, Trends in biochemical sciences.

[113]  K. Bhalla,et al.  Overexpression of Bcl-X(L) inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis. , 1997, Cancer research.

[114]  P. Beart,et al.  Apoptosis Induced via AMPA‐Selective Glutamate Receptors in Cultured Murine Cortical Neurons , 1997, Journal of neurochemistry.

[115]  R. Sapolsky,et al.  Herpes Simplex Viral Vectors Expressing Bcl-2 Are Neuroprotective When Delivered After a Stroke , 1997, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[116]  H. Manev,et al.  Characterization of Zinc-Induced Neuronal Death in Primary Cultures of Rat Cerebellar Granule Cells , 1997, Experimental Neurology.

[117]  R. Weichselbaum,et al.  Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[118]  R. Monette,et al.  Glutamate-treated rat cortical neuronal cultures die in a way different from the classical apoptosis induced by staurosporine. , 1997, Experimental cell research.

[119]  C. Kurschner,et al.  Modulation of Cell Death in Yeast by the Bcl-2 Family of Proteins* , 1997, The Journal of Biological Chemistry.

[120]  G M Bokoch,et al.  Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. , 1997, Science.

[121]  E. Ma,et al.  Anoxia regulates gene expression in the central nervous system of Drosophila melanogaster. , 1997, Brain research. Molecular brain research.

[122]  M. Seldin,et al.  Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene. , 1997, Journal of immunology.

[123]  Stephen N. Jones,et al.  Regulation of p53 stability by Mdm2 , 1997, Nature.

[124]  J C Reed,et al.  Channel formation by antiapoptotic protein Bcl-2. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[125]  Y. Hsu,et al.  Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[126]  P. Krammer,et al.  Interleukin 1β-converting Enzyme Related Proteases/Caspases Are Involved in TRAIL-induced Apoptosis of Myeloma and Leukemia Cells , 1997, The Journal of cell biology.

[127]  T. Curran,et al.  Identification of redox/repair protein Ref-1 as a potent activator of p53. , 1997, Genes & development.

[128]  R. Meadows,et al.  Structure of Bcl-xL-Bak Peptide Complex: Recognition Between Regulators of Apoptosis , 1997, Science.

[129]  A. Levine p53, the Cellular Gatekeeper for Growth and Division , 1997, Cell.

[130]  S. Nagata,et al.  Apoptosis by Death Factor , 1997, Cell.

[131]  C. Portera-Cailliau,et al.  Excitotoxic neuronal death in the immature brain is an apoptosis‐necrosis morphological continuum , 1997, The Journal of comparative neurology.

[132]  John Calvin Reed,et al.  Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe. , 1997, Molecular biology of the cell.

[133]  G. Evan,et al.  Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak , 1997, The Journal of cell biology.

[134]  A. Strasser,et al.  The cell death inhibitor Bcl‐2 and its homologues influence control of cell cycle entry. , 1996, The EMBO journal.

[135]  C. Milliman,et al.  BID: a novel BH3 domain-only death agonist. , 1996, Genes & development.

[136]  John Calvin Reed,et al.  Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria , 1996, Cell.

[137]  Elizabeth Yang,et al.  Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL , 1996, Cell.

[138]  D. Choi,et al.  Ischemia-induced neuronal apoptosis , 1996, Current Opinion in Neurobiology.

[139]  G. Linette,et al.  Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[140]  John Calvin Reed,et al.  Altered expression of Bcl-2, Bcl-X, Bax, and c-Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats. , 1996, Brain Research. Molecular Brain Research.

[141]  K. Vousden,et al.  Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function , 1996, Molecular and cellular biology.

[142]  H. Hatanaka,et al.  Free radical-independent protection by nerve growth factor and Bcl-2 of PC12 cells from hydrogen peroxide-triggered apoptosis. , 1996, Journal of biochemistry.

[143]  A. Eastman,et al.  The Involvement of Protein Phosphatases in the Activation of ICE/CED-3 Protease, Intracellular Acidification, DNA Digestion, and Apoptosis* , 1996, The Journal of Biological Chemistry.

[144]  John Calvin Reed,et al.  Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[145]  N. Thornberry,et al.  The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis , 1996, Nature Structural Biology.

[146]  J. Li,et al.  BCL-2 and MCL-1 expression in Chinese hamster ovary cells inhibits intracellular acidification and apoptosis induced by staurosporine. , 1996, Experimental cell research.

[147]  D. Goeddel,et al.  TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. , 1996, Immunity.

[148]  S. Terakawa,et al.  Nuclear disintegration as a leading step of glutamate excitotoxicity in brain neurons , 1996, Journal of neuroscience research.

[149]  A. Chinnaiyan,et al.  FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis (*) , 1996, The Journal of Biological Chemistry.

[150]  Hong-Bing Shu,et al.  TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways , 1996, Cell.

[151]  G. Steinberg,et al.  Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[152]  Mike Rothe,et al.  The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins , 1995, Cell.

[153]  R. Hata,et al.  Localization of Fas antigen mRNA induced in postischemic murine forebrain by in situ hybridization. , 1995, Brain research. Molecular brain research.

[154]  D. Bredesen,et al.  Bcl‐2 Protects Neural Cells from Cyanide/Aglycemia‐Induced Lipid Oxidation, Mitochondrial Injury, and Loss of Viability , 1995, Journal of neurochemistry.

[155]  C A Smith,et al.  Identification and characterization of a new member of the TNF family that induces apoptosis. , 1995, Immunity.

[156]  P. O'Connor,et al.  Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA. , 1995, Oncogene.

[157]  T. Chittenden,et al.  A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. , 1995, The EMBO journal.

[158]  D. Choi,et al.  Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro , 1995, Neuroscience.

[159]  G. Linette,et al.  Bcl-XL and Bcl-2 repress a common pathway of cell death , 1995, The Journal of experimental medicine.

[160]  D. Haber,et al.  The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis. , 1995, Genes & development.

[161]  M. Geschwind,et al.  Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia. , 1995, Stroke.

[162]  Z. Oltvai,et al.  Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[163]  C Haanen,et al.  A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. , 1995, Journal of immunological methods.

[164]  D. Mukhopadhyay,et al.  Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation , 1995, Nature.

[165]  C. Thompson,et al.  bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[166]  A. Privat,et al.  Presence of the long and the short forms of Bcl-X in several human and murine tissues. , 1995, Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie.

[167]  Matthew J. Brauer,et al.  Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak , 1995, Nature.

[168]  G. Evan,et al.  Induction of apoptosis by the Bcl-2 homologue Bak , 1995, Nature.

[169]  F. Mollinedo,et al.  Intracellular Alkalinization Suppresses Lovastatin-induced Apoptosis in HL-60 Cells through the Inactivation of a pH-dependent Endonuclease (*) , 1995, The Journal of Biological Chemistry.

[170]  S. Nagata,et al.  The Fas death factor , 1995, Science.

[171]  M. Dragunow,et al.  Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous system. , 1995, Pharmacological reviews.

[172]  John Calvin Reed,et al.  Tumor suppressor p53 is a direct transcriptional activator of the human bax gene , 1995, Cell.

[173]  P. O'Connor,et al.  Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. , 1994, Science.

[174]  B. Zhivotovsky,et al.  Nuclear calcium transport and the role of calcium in apoptosis. , 1994, Cell calcium.

[175]  M. Zoratti,et al.  Electrophysiology of the inner mitochondrial membrane , 1994, Journal of bioenergetics and biomembranes.

[176]  John Calvin Reed,et al.  Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[177]  Andrew J. Bannister,et al.  c-Fos-induced activation of a TATA-box-containing promoter involves direct contact with TATA-box-binding protein , 1994, Molecular and cellular biology.

[178]  T. Graeber,et al.  Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status , 1994, Molecular and cellular biology.

[179]  G. Dubyak,et al.  Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[180]  A. Ishida,et al.  Increase in bcl-2 oncoprotein and the tolerance to ischemia-induced neuronal death in the gerbil hippocampus , 1994, Neuroscience Research.

[181]  W. Snider,et al.  Functions of the neurotrophins during nervous system development: What the knockouts are teaching us , 1994, Cell.

[182]  Z. Oltvai,et al.  BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax , 1994, Nature.

[183]  J. Woodgett,et al.  The stress-activated protein kinase subfamily of c-Jun kinases , 1994, Nature.

[184]  M. Mattson,et al.  NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults , 1994, Brain Research.

[185]  M. Linnik,et al.  Evidence Supporting a Role for Programmed Cell Death in Focal Cerebral Ischemia in Rats , 1993, Stroke.

[186]  Shai Shaham,et al.  The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme , 1993, Cell.

[187]  P. Meers,et al.  Calcium-dependent annexin V binding to phospholipids: stoichiometry, specificity, and the role of negative charge. , 1993, Biochemistry.

[188]  G. Haddad,et al.  Mechanisms of anoxia-induced depolarization in brainstem neurons: in vitro current and voltage clamp studies in the adult rat , 1993, Brain Research.

[189]  S. Varon,et al.  Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[190]  D. Bredesen,et al.  bcl-2 inhibits death of central neural cells induced by multiple agents. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[191]  M. Dyer,et al.  Ultrastructural localization of bcl-2 protein. , 1992, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[192]  S. Ben‐Sasson,et al.  Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation , 1992, The Journal of cell biology.

[193]  A. Levine,et al.  Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[194]  B. Price,et al.  Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins. , 1992, Cancer research.

[195]  D. Meek,et al.  Phosphorylation of the p53 tumour-suppressor protein at three N-terminal sites by a novel casein kinase I-like enzyme. , 1992, Oncogene.

[196]  Tom L. Blundell,et al.  Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product , 1992, Cell.

[197]  M. Mattson,et al.  NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis , 1991, Neuron.

[198]  R. Bravo,et al.  Expression of different Jun and Fos proteins during the G0-to-G1 transition in mouse fibroblasts: in vitro and in vivo associations , 1991, Molecular and cellular biology.

[199]  R. Bravo,et al.  c-JUN, JUN B, and JUN D differ in their binding affinities to AP-1 and CRE consensus sequences: effect of FOS proteins. , 1991, Oncogene.

[200]  H. Thoenen,et al.  Effect of ciliary neurotrophic factor (CNTF) on motoneuron survival , 1991, Journal of Cell Science.

[201]  C. Anderson,et al.  Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen , 1990, Molecular and cellular biology.

[202]  A. Graybiel,et al.  Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[203]  E. Johnson,et al.  Nerve growth factor regulates sympathetic ganglion cell morphology and survival in the adult mouse , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[204]  M. Greenberg,et al.  The regulation and function of c-fos and other immediate early genes in the nervous system , 1990, Neuron.

[205]  J. Minna,et al.  jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun , 1989, Cell.

[206]  M. Karin,et al.  Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun , 1989, Cell.

[207]  T. Hunter,et al.  The c-fos protein interacts with c-Jun AP-1 to stimulate transcription of AP-1 responsive genes , 1988, Cell.

[208]  M. Sheng,et al.  Calcium and growth factor pathways of c-fos transcriptional activation require distinct upstream regulatory sequences , 1988, Molecular and cellular biology.

[209]  R. Lindsay,et al.  Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[210]  R. Levi‐montalcini,et al.  The nerve growth factor 35 years later. , 1987, Science.

[211]  E. Shooter,et al.  Gene transfer and molecular cloning of the rat nerve growth factor receptor , 1987, Nature.

[212]  D. Choi Ionic dependence of glutamate neurotoxicity , 1987, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[213]  M. Chao,et al.  Expression and structure of the human NGF receptor , 1986, Cell.

[214]  M. Greenberg,et al.  Stimulation of neuronal acetylcholine receptors induces rapid gene transcription. , 1986, Science.

[215]  E. Pettersen,et al.  Regulation of protein metabolism of human cells during and after acute hypoxia. , 1986, Cancer research.

[216]  Y. Tsujimoto,et al.  Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[217]  M. Greenberg,et al.  Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells. , 1985, The Journal of biological chemistry.

[218]  J. Sklar,et al.  Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[219]  G. Grisetti,et al.  Further Reading , 1984, IEEE Spectrum.

[220]  S. Penman,et al.  Regulation of protein synthesis in HeLa cells: translation at elevated temperatures. , 1969, Journal of molecular biology.

[221]  H. Perlman,et al.  An elevated bax/bcl-2 ratio corresponds with the onset of prostate epithelial cell apoptosis , 1999, Cell Death and Differentiation.

[222]  P. Gaehtgens,et al.  Bcl-Xl- and Bax-alpha-mediated regulation of apoptosis of human neutrophils via caspase-3. , 1999, Blood.

[223]  A. Bruskin,et al.  Identification and characterization of baxepsilon, a novel bax variant missing the BH2 and the transmembrane domains. , 1999, Biochemical and Biophysical Research Communications - BBRC.

[224]  L. Zhou,et al.  Distinct cell killing properties of the Drosophila reaper, head involution defective, and grim genes , 1999, Cell Death and Differentiation.

[225]  C Gélinas,et al.  The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis. , 1999, Genes & development.

[226]  John Calvin Reed,et al.  Bcl‐2, Raf‐1 and mitochondrial regulation of apoptosis , 1998, BioFactors.

[227]  D. Chao,et al.  BCL-2 family: regulators of cell death. , 1998, Annual review of immunology.

[228]  N. Futrell,et al.  Gene expression of IL-10 in relationship to TNF-alpha, IL-1beta and IL-2 in the rat brain following middle cerebral artery occlusion. , 1997, Journal of the neurological sciences.

[229]  D. Stephenson,et al.  Global cerebral ischemia activates nuclear factor-kappa B prior to evidence of DNA fragmentation. , 1997, Brain research. Molecular brain research.

[230]  E. Preston,et al.  Increases in DNA lesions and the DNA damage indicator Gadd45 following transient cerebral ischemia. , 1997, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[231]  D. Bredesen,et al.  Expression of bcl-2 inhibits cellular radical generation. , 1996, Free radical research.

[232]  M. Mattson,et al.  Endogenous neuroprotection factors and traumatic brain injury: mechanisms of action and implications for therapy. , 1994, Journal of neurotrauma.

[233]  D. Lane,et al.  Regulation of the cryptic sequence-specific DNA-binding function of p53 by protein kinases. , 1994, Cold Spring Harbor symposia on quantitative biology.

[234]  L. Tartaglia,et al.  Two TNF receptors. , 1992, Immunology today.

[235]  T. Curran,et al.  Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. , 1991, Annual review of neuroscience.

[236]  A. Wyllie Cell death: a new classification separating apoptosis from necrosis , 1981 .

[237]  P. Patterson,et al.  ROLE OF NERVE GROWTH FACTOR IN THE DEVELOPMENT OF RAT SYMPATHETIC NEURONS IN VITRO , 1977 .

[238]  L. Rubin,et al.  Blocking Cytochrome c Activity within Intact Neurons Inhibits Apoptosis , 1998, The Journal of cell biology.