Cellular mechanotransduction: stiffness does matter.

Extracellular-matrix stiffness regulates cell behaviour even when decoupled from ligand density and tethering.

[1]  S. Sen,et al.  Matrix Elasticity Directs Stem Cell Lineage Specification , 2006, Cell.

[2]  Ravi A. Desai,et al.  Mechanical regulation of cell function with geometrically modulated elastomeric substrates , 2010, Nature Methods.

[3]  Yu Suk Choi,et al.  Interplay of Matrix Stiffness and Protein Tethering in Stem Cell Differentiation , 2014, Nature materials.

[4]  Sanjay Kumar,et al.  Independent regulation of tumor cell migration by matrix stiffness and confinement , 2012, Proceedings of the National Academy of Sciences.

[5]  Kevin W. Eliceiri,et al.  Matrix density-induced mechanoregulation of breast cell phenotype, signaling, and gene expression through a FAK-ERK linkage , 2009, Oncogene.

[6]  Cynthia A. Reinhart-King,et al.  Tensional homeostasis and the malignant phenotype. , 2005, Cancer cell.

[7]  D. G. T. Strange,et al.  Extracellular-matrix tethering regulates stem-cell fate. , 2012, Nature materials.

[8]  Amit Pathak,et al.  Biophysical regulation of tumor cell invasion: moving beyond matrix stiffness. , 2011, Integrative biology : quantitative biosciences from nano to macro.

[9]  Sanjay Kumar,et al.  The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells. , 2009, Cancer research.

[10]  Y. Wang,et al.  Cell locomotion and focal adhesions are regulated by substrate flexibility. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[11]  Albert J. Keung,et al.  Rho GTPases Mediate the Mechanosensitive Lineage Commitment of Neural Stem Cells , 2011, Stem cells.

[12]  David J Mooney,et al.  Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium. , 2014, Nature materials.