Familial adenomatous polyposis‐associated and sporadic pyloric gland adenomas of the upper gastrointestinal tract share common genetic features

Familial adenomatous polyposis (FAP) is a hereditary cancer predisposition syndrome caused by a germline APC mutation. A recent study showed the enrichment of pyloric gland adenomas (PGAs) of the stomach, in addition to fundic gland polyps (FGPs) and foveolar‐type adenomas (FAs), in patients with FAP. In the present study, we analysed the genetic alterations in these FAP‐associated gastric lesions.

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