A novel series of cysteine-dependent, allosteric inverse agonists of the nuclear receptor RORγt.
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I. Dulubova | D. Ferguson | Liping Liu | S. Reisman | Xin Jiang | Isaac Treviño | Melean Visnick | Lyndsey McCauley | Chun-Yue I. Lee | Yiğitcan Eken | A. Wilson | Martha R Hotema | W. Wigley
[1] Ruben D. Garcia-Ordonez,et al. HDX-MS reveals structural determinants for ROR gamma hyperactivation by synthetic agonists. , 2019 .
[2] Sachchidanand,et al. Combating Autoimmune Diseases With Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ or RORc) Inhibitors: Hits and Misses. , 2018, Journal of medicinal chemistry.
[3] S. Knapp,et al. The Cysteinome of Protein Kinases as a Target in Drug Development. , 2018, Angewandte Chemie.
[4] Alan Menter,et al. Anti‐IL‐23 and Anti‐IL‐17 Biologic Agents for the Treatment of Immune‐Mediated Inflammatory Conditions , 2018, Clinical pharmacology and therapeutics.
[5] E. Thoreau,et al. Discovery of phenoxyindazoles and phenylthioindazoles as RORγ inverse agonists. , 2016, Bioorganic & medicinal chemistry letters.
[6] F. Gervasio,et al. Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. , 2016, Cell chemical biology.
[7] M. Mańczak,et al. RORC2 Genetic Variants and Serum Levels in Patients with Rheumatoid Arthritis , 2016, International journal of molecular sciences.
[8] C. Ottmann,et al. Identification of an allosteric binding site for RORγt inhibition , 2015, Nature Communications.
[9] K. Smith,et al. Assessment of murine collagen-induced arthritis by longitudinal non-invasive duplexed molecular optical imaging. , 2015, Rheumatology.
[10] T. Morio,et al. RORγt-specific transcriptional interactomic inhibition suppresses autoimmunity associated with TH17 cells , 2014, Proceedings of the National Academy of Sciences.
[11] Mark S. Sundrud,et al. Targeting Th17 cells in autoimmune diseases. , 2014, Trends in pharmacological sciences.
[12] F. Grun. Covalent Interactions of Organotins with Nuclear Receptors , 2012 .
[13] Yong Li,et al. Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma. , 2010, Molecular endocrinology.
[14] D. Littman,et al. The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt , 2008, Nature Immunology.
[15] B. Bishop,et al. Identification of catalytic cysteine, histidine, and lysine residues in Escherichia coli homoserine transsuccinylase. , 2007, Biochemistry.
[16] Jan H. Jensen,et al. Very fast empirical prediction and rationalization of protein pKa values , 2005, Proteins.
[17] N. Kamiya,et al. α,β-Unsaturated Ketone Is a Core Moiety of Natural Ligands for Covalent Binding to Peroxisome Proliferator-activated Receptor γ* , 2005, Journal of Biological Chemistry.
[18] J. Dixon,et al. Active site labeling of the Yersinia protein tyrosine phosphatase: the determination of the pKa of the active site cysteine and the function of the conserved histidine 402. , 1993, Biochemistry.