Detailed Method for Intrathecal Delivery of Gene Therapeutics by Direct Lumbar Puncture in Mice.

[1]  Xiao Li,et al.  Upregulation of NLRP3 via STAT3-dependent histone acetylation contributes to painful neuropathy induced by bortezomib , 2018, Experimental Neurology.

[2]  N. Boulis,et al.  AAV gene delivery to the spinal cord: serotypes, methods, candidate diseases, and clinical trials , 2018, Expert opinion on biological therapy.

[3]  N. Morioka,et al.  Downregulation of spinal astrocytic connexin43 leads to upregulation of interleukin‐6 and cyclooxygenase‐2 and mechanical hypersensitivity in mice , 2018, Glia.

[4]  N. Mellios,et al.  Effects of spinal non-viral interleukin-10 gene therapy formulated with d-mannose in neuropathic interleukin-10 deficient mice: Behavioral characterization, mRNA and protein analysis in pain relevant tissues , 2017, Brain, Behavior, and Immunity.

[5]  Chunsheng Hu,et al.  Gene therapy for neuropathic pain induced by spared nerve injury with naked plasmid encoding hepatocyte growth factor , 2017, The journal of gene medicine.

[6]  R. Schmidt,et al.  Synergistic effects of treating the spinal cord and brain in CLN1 disease , 2017, Proceedings of the National Academy of Sciences.

[7]  Q. Wan,et al.  Activation of the RAGE/STAT3 Pathway in the Dorsal Root Ganglion Contributes to the Persistent Pain Hypersensitivity Induced by Lumbar Disc Herniation. , 2017, Pain physician.

[8]  He Li,et al.  Activation of STAT3-mediated CXCL12 up-regulation in the dorsal root ganglion contributes to oxaliplatin-induced chronic pain , 2017, Molecular pain.

[9]  N. Morioka,et al.  Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice , 2015, Brain, Behavior, and Immunity.

[10]  G. Pasternak,et al.  Mediation of opioid analgesia by a truncated 6-transmembrane GPCR. , 2015, The Journal of clinical investigation.

[11]  P. Aebischer,et al.  SOD1 silencing in motoneurons or glia rescues neuromuscular function in ALS mice , 2015, Annals of clinical and translational neurology.

[12]  Ran Liu,et al.  Reversal of bone cancer pain by HSV-1-mediated silencing of CNTF in an afferent area of the spinal cord associated with AKT-ERK signal inhibition. , 2014, Current gene therapy.

[13]  L. Belur,et al.  Supraspinal gene transfer by intrathecal adeno-associated virus serotype 5 , 2014, Front. Neuroanat..

[14]  L. Belur,et al.  Biodistribution of adeno-associated virus serotype 9 (AAV9) vector after intrathecal and intravenous delivery in mouse , 2014, Front. Neuroanat..

[15]  M. Tominaga,et al.  Intrathecal AAV serotype 9-mediated delivery of shRNA against TRPV1 attenuates thermal hyperalgesia in a mouse model of peripheral nerve injury. , 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

[16]  C. N. Honda,et al.  Visualization of spinal afferent innervation in the mouse colon by AAV8‐mediated GFP expression , 2013, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[17]  W. Zou,et al.  Intrathecal herpes simplex virus type 1 amplicon vector-mediated human proenkephalin reduces chronic constriction injury-induced neuropathic pain in rats. , 2011, Molecular medicine reports.

[18]  L. Belur,et al.  Differential adeno-associated virus mediated gene transfer to sensory neurons following intrathecal delivery by direct lumbar puncture. , 2010, Molecular pain.

[19]  P. Aebischer,et al.  Recombinant adeno-associated virus serotype 6 (rAAV2/6)-mediated gene transfer to nociceptive neurons through different routes of delivery , 2009, Molecular pain.

[20]  J. Bastacky,et al.  Intrathecal administration of AAV vectors for the treatment of lysosomal storage in the brains of MPS I mice , 2006, Gene Therapy.

[21]  C. Fairbanks Spinal delivery of analgesics in experimental models of pain and analgesia. , 2003, Advanced drug delivery reviews.

[22]  A. Eschalier,et al.  A method to perform direct transcutaneous intrathecal injection in rats. , 1994, Journal of pharmacological and toxicological methods.

[23]  G. Wilcox,et al.  Intrathecal morphine in mice: a new technique. , 1980, European journal of pharmacology.