Supersaturation tracking for the development, optimization and control of crystallization processes

[1]  J. E. Helt,et al.  Effects of temperature on the crystallization of potassium nitrate by direct measurement of supersaturation , 1977 .

[2]  I. Jolliffe.  A Note on the Use of Principal Components in Regression , 1982 .

[3]  Dilum D. Dunuwila,et al.  ATR FTIR spectroscopy for in situ measurement of supersaturation , 1997 .

[4]  A K Smilde,et al.  Influence of temperature on vibrational spectra and consequences for the predictive ability of multivariate models. , 1998, Analytical chemistry.

[5]  F. Puel,et al.  Improving batch cooling seeded crystallization of an organic weed-killer using on-line ATR FTIR measurement of supersaturation , 2001 .

[6]  K. Roberts,et al.  Nucleation, Growth, and Pseudo-Polymorphic Behavior of Citric Acid As Monitored in Situ by Attenuated Total Reflection Fourier Transform Infrared Spectroscopy , 2001 .

[7]  B. Glennon,et al.  Characterizing the metastable zone width and solubility curve using lasentec FBRM and PVM , 2002 .

[8]  F. Puel,et al.  An Online Strategy To Increase the Average Crystal Size during Organic Batch Cooling Crystallization , 2002 .

[9]  R. Braatz,et al.  Paracetamol Crystallization Using Laser Backscattering and ATR-FTIR Spectroscopy: Metastability, Agglomeration, and Control , 2002 .

[10]  Lawrence X. Yu,et al.  Applications of process analytical technology to crystallization processes. , 2004, Advanced drug delivery reviews.

[11]  V. Liotta,et al.  Monitoring and Feedback Control of Supersaturation Using ATR-FTIR to Produce an Active Pharmaceutical Ingredient of a Desired Crystal Size , 2004 .

[12]  Richard D. Braatz,et al.  First-principles and direct design approaches for the control of pharmaceutical crystallization , 2005 .

[13]  M. W. Wood-Kaczmar,et al.  Solute concentration measurement of an important organic compound using ATR-UV spectroscopy , 2005 .

[14]  B. Glennon,et al.  Application of in Situ FBRM and ATR-FTIR to the Monitoring of the Polymorphic Transformation of d-Mannitol , 2005 .

[15]  Kati Pöllänen,et al.  A Study on Batch Cooling Crystallization of Sulphathiazole: Process Monitoring Using ATR-FTIR and Product Characterization by Automated Image Analysis , 2006 .

[16]  Reginald B. H. Tan,et al.  Seeding and constant-supersaturation control by ATR-FTIR in anti-solvent crystallization , 2006 .

[17]  R. Braatz,et al.  Direct design of pharmaceutical antisolvent crystallization through concentration control , 2006 .

[18]  Jia Wei Chew,et al.  Automated In-line Technique Using FBRM to Achieve Consistent Product Quality in Cooling Crystallization , 2007 .

[19]  B. Glennon,et al.  The Effect of Mixing on the Metastable Zone Width and Nucleation Kinetics in the Anti-Solvent Crystallization of Benzoic Acid , 2007 .

[20]  J. Chew,et al.  Comparison between Open-Loop Temperature Control and Closed-Loop Supersaturation Control for Cooling Crystallization of Glycine , 2007 .

[21]  Z. Nagy,et al.  Comparative performance of concentration and temperature controlled batch crystallizations , 2008 .

[22]  M. Mazzotti,et al.  Quantitative Application of in Situ ATR-FTIR and Raman Spectroscopy in Crystallization Processes , 2008 .

[23]  Z. Nagy,et al.  Adaptive concentration control of cooling and antisolvent crystallization with laser backscattering measurement , 2009 .

[24]  George Zhou,et al.  A Novel Crystallization Methodology To Ensure Isolation of the Most Stable Crystal Form , 2009 .

[25]  Julian Morris,et al.  On-line monitoring of batch cooling crystallization of organic compounds using ATR-FTIR spectroscopy coupled with an advanced calibration method , 2009 .

[26]  Zoltan K. Nagy,et al.  A Process Analytical Technology Based Investigation of the Polymorphic Transformations during the Antisolvent Crystallization of Sodium Benzoate from IPA/Water Mixture , 2009 .

[27]  Marco Mazzotti,et al.  Design and Optimization of a Combined Cooling/Antisolvent Crystallization Process , 2009 .

[28]  Ali N. Saleemi,et al.  The impact of direct nucleation control on crystal size distribution in pharmaceutical crystallization processes , 2009 .