A directive antenna array applicator for focused electromagnetic hyperthermia treatment of breast cancer

A hyperthermia applicator is designed for the treatment of breast cancer with 24 directive microstrip spiral antennas forming a hemispherical array at 434 MHz. All individual antennas are directed towards a target region and their phases are adapted to focus all the fields at the targeted region. The measurements are performed by submerging uniform liquid solutions inside the applicator which completely stand inside distilled water. By exposing uniform liquid solutions to focused waves we observed temperature distribution with respect to time.

[1]  Paolo F Maccarini,et al.  Improved hyperthermia treatment control using SAR/temperature simulation and PRFS magnetic resonance thermal imaging , 2011, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[2]  D Machin,et al.  Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. International Collaborative Hyperthermia Group. , 1996, International journal of radiation oncology, biology, physics.

[3]  E. Korkmaz,et al.  Electromagnetic modeling of a female breast hyperthermia applicator , 2013, 2013 IEEE Antennas and Propagation Society International Symposium (APSURSI).

[4]  Vlayka Liotcheva,et al.  A phase I/II study of neoadjuvant liposomal doxorubicin, paclitaxel, and hyperthermia in locally advanced breast cancer , 2010, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[5]  Mahta Moghaddam,et al.  A Preclinical System Prototype for Focused Microwave Thermal Therapy of the Breast , 2012, IEEE Transactions on Biomedical Engineering.

[6]  Kung-Shan Cheng,et al.  Effective learning strategies for real-time image-guided adaptive control of multiple-source hyperthermia applicators. , 2010, Medical physics.

[7]  E. Neufeld,et al.  The HYPERcollar: A novel applicator for hyperthermia in the head and neck , 2007 .

[8]  P. Wust,et al.  The cellular and molecular basis of hyperthermia. , 2002, Critical reviews in oncology/hematology.

[9]  S. Watanabe,et al.  Dielectric properties of tissue-equivalent liquids and their effects on specific absorption rate , 2004, IEEE Transactions on Electromagnetic Compatibility.

[10]  B. Turetken,et al.  Design of compact microstrip antennas embedded in water bolus for hyperthermia applications , 2012, Proceedings of the 2012 IEEE International Symposium on Antennas and Propagation.

[11]  Erdal Korkmaz,et al.  A Compact Microstrip Spiral Antenna Embedded in Water Bolus for Hyperthermia Applications , 2013 .

[12]  E. Topsakal,et al.  Characterization and Testing of a Skin Mimicking Material for Implantable Antennas Operating at ISM Band (2.4 GHz-2.48 GHz) , 2008, IEEE Antennas and Wireless Propagation Letters.

[13]  R. W. Lau,et al.  The dielectric properties of biological tissues: II. Measurements in the frequency range 10 Hz to 20 GHz. , 1996, Physics in medicine and biology.

[14]  Gerard C. van Rhoon,et al.  Introduction: Non-invasive thermometry for thermotherapy , 2005, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[15]  Kavitha Arunachalam,et al.  Conformal microwave array (CMA) applicators for hyperthermia of diffuse chest wall recurrence , 2010, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[16]  J. Zee.  Heating the patient : a promising approach ? , 2002 .

[17]  B. Turetken,et al.  Development of a hyperthermia applicator with compact microstrip antennas , 2012, Proceedings of the 2012 IEEE International Symposium on Antennas and Propagation.

[18]  G. Houston,et al.  Laboratory prototype for experimental validation of MR-guided radiofrequency head and neck hyperthermia , 2014, Physics in medicine and biology.