Therapy of advanced squamous carcinoma of the lung. Cyclophosphamide versus “COMB”

The four‐drug combination of cyclophosphamide, vincristine, methyl CCNU and bleomycin was compared to CTX alone in a prospective randomized trial. Only one of 20 patients treated with COMB and one of 27 patients treated with CTX achieved a partial response. CTX was associated with a significantly better survival than COMB among patients who were ambulatory at onset of therapy. Survival among non‐ambulatory patients was similar with both regimens.