Further recommended reading Reviews of animal models of ELS

Avishai-Eliner S, Brunson KL, Sandman CA, Baram TZ (2002). Stressed-out, or in (utero)? Trends Neurosci. 25: 518–524. Baram TZ, Davis EP, Obenaus A, Sandman CA, Small SL, Solodkin A, Stern H (2012). Fragmentation and unpredictability of early-life experience in mental disorders. Am J Psychiatry. 169: 907–915 Champagne FA, Francis DD, Mar A, Meaney MJ (2003). Variations in maternal care in the rat as a mediating influence for the effects of environment on development. Physiol Behav. 79: 359–371. [Early detailed analysis of maternal care behaviours in high and low LG-ABN dams.] Ivy AS, Brunson KL, Sandman C, Baram TZ (2008). Dysfunctional nurturing behavior in rat damswith limited access to nestingmaterial: a clinically relevantmodel for early-life stress.Neuroscience. 154: 1132–1142. [First data showing how limited nesting paradigm alters the pattern of maternal care.] Levine S (1957).Infantile experience and resistance to physiological stress. Science. 126: 405. [Seminal study showing how early experience alters development of stress response.] Maccari S., Morley-Fletcher S (2007). Effects of prenatal restraint stress on the Hypothalamus–pituitary–adrenal axis and related behavioural and neurobiological alterations. Psychoneuroendocrinology. 32 S1: S10–15. Maras PM, Baram TZ (2012). Sculpting the hippocampus from within: stress, spines, and CRH. Trends Neurosci. 35: 315–324. McCormick CM, Green MR (2012). From the stressed adolescent to the anxious and depressed adult: investigations in rodent models. Neuroscience. 249: 242–257. doi: 10.1016/j.neuroscience.2012.08.063. Millstein RA, Holmes A (2007). Effects of repeated maternal separation on anxietyand depression-related phenotypes in different mouse strains. Neurosci Biobehav Rev. 31: 3–17. Moriceau S, Shionoya K, Jakubs K, Sullivan RM (2009). Early-life stress disrupts attachment learning: the role of amygdala corticosterone, locus ceruleus corticotropin releasing hormone, and olfactory bulb norepinephrine. J Neurosci. 29: 15745–15755. Seay B, Hansen E, Harlow HF (1962). Mother–infant separation in monkeys. J Child Psychol Psychiatry. 3: 123–132. [Influential work demonstrating the critical role of mother–offspring bonds in development.] UNICEF (2005). State of the World’s Children: Children under Threat 2005, UNICEF, New York.

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[24]  F. Holsboer,et al.  Forebrain CRF1 Modulates Early-Life Stress-Programmed Cognitive Deficits , 2011, The Journal of Neuroscience.

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