Ethinyl Estradiol, Not Progestogens, Reduces Lamotrigine Serum Concentrations

Summary:  Purpose: To study the interaction between lamotrigine (LTG) and hormonal contraception.

[1]  J. Murty.  Maintenance of ovulation inhibition with 75 μg desogestrel-only contraceptive pill (Cerazette®) after scheduled 12-h delays in tablet intake , 2005, Journal of family planning and reproductive health care.

[2]  D. Blum,et al.  A bi-directional pharmacokinetic interaction study of lamotrigine and the Combined Oral Contraceptive (COC) pill in healthy subjects , 2005 .

[3]  D. Heger-Mahn,et al.  Maintenance of ovulation inhibition with the 75-microg desogestrel-only contraceptive pill (Cerazette) after scheduled 12-h delays in tablet intake. , 2005, Contraception.

[4]  T. Tomson.  Drug selection for the newly diagnosed patient: When is a new generation antiepileptic drug indicated? , 2004, Journal of Neurology.

[5]  F. Stanczyk.  Pharmacokinetics and Potency of Progestins used for Hormone Replacement Therapy and Contraception , 2002, Reviews in Endocrine and Metabolic Disorders.

[6]  T. Tomson,et al.  Oral contraceptives reduce lamotrigine plasma levels , 2003, Neurology.

[7]  Martha Morrell,et al.  Reproductive and Metabolic Disorders in Women with Epilepsy , 2003, Epilepsia.

[8]  P. Uldall,et al.  Lamotrigine plasma levels reduced by oral contraceptives , 2001, Epilepsy Research.

[9]  C. Timmer,et al.  Pharmacokinetics of Etonogestrel and Ethinylestradiol Released from a Combined Contraceptive Vaginal Ring , 2000, Clinical pharmacokinetics.

[10]  W. Wnuk,et al.  TOPIRAMATE DECREASES LAMOTRIGIN CONCENTRATIONS , 1999 .

[11]  R. Gerner,et al.  Lamotrigine toxicity secondary to sertraline , 1998, Seizure.

[12]  T. May,et al.  Serum concentrations of lamotrigine in epileptic patients: the influence of dose and comedication. , 1996, Therapeutic drug monitoring.