Numerical stability and convergence analysis of bone remodeling model

Abstract Bone remodeling is the mechanism that regulates the relationship between bone morphology and its external mechanical loads. It is based on the fact that bone adapts itself to the mechanical conditions to which it is exposed. The first phenomenological law that qualitatively described this mechanism is generally known as Wolff’s law. During recent decades, a great number of numerically implemented mathematical laws have been proposed, but most of them have not presented a full analysis of stability and convergence. In this paper, we revisit the Stanford bone remodeling theory where a novel assumption is proposed, which considers that the reference equilibrium stimulus is dependent on the loading history. Fully discrete approximations are introduced by using the finite element method and the explicit Euler scheme. Some a priori error estimates are proved, from which the linear convergence of the algorithm is deduced under additional regularity conditions. Numerical simulations are presented to demonstrate the behavior of the solution. This modification improves the convergence of the solution, clearly leading to its numerical stability in the long-term.

[1]  J. M. Garcı́a,et al.  Modelling bone tissue fracture and healing: a review ☆ , 2004 .

[2]  L Kaczmarczyk,et al.  Efficient numerical analysis of bone remodelling. , 2011, Journal of the mechanical behavior of biomedical materials.

[3]  Gideon A. Rodan,et al.  Control of osteoblast function and regulation of bone mass , 2003, Nature.

[4]  G. Beaupré,et al.  Skeletal Function and Form: Mechanobiology of Skeletal Development, Aging, and Regeneration , 2003 .

[5]  H. Frost Skeletal structural adaptations to mechanical usage (SATMU): 2. Redefining Wolff's Law: The remodeling problem , 1990, The Anatomical record.

[6]  D. Carter Mechanical loading history and skeletal biology. , 1987, Journal of biomechanics.

[7]  Martin Rb Porosity and specific surface of bone. , 1984 .

[8]  P. Clément Approximation by finite element functions using local regularization , 1975 .

[9]  J. M. Garcı́a,et al.  Anisotropic bone remodelling model based on a continuum damage-repair theory. , 2002, Journal of biomechanics.

[10]  H. Grootenboer,et al.  The behavior of adaptive bone-remodeling simulation models. , 1992, Journal of biomechanics.

[11]  G S Beaupré,et al.  An approach for time‐dependent bone modeling and remodeling—theoretical development , 1990, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[12]  G. Bergmann,et al.  Hip contact forces and gait patterns from routine activities. , 2001, Journal of biomechanics.

[13]  Gholamreza Rouhi,et al.  A model for mechanical adaptation of trabecular bone incorporating cellular accommodation and effects of microdamage and disuse , 2009 .

[14]  H. Grootenboer,et al.  Adaptive bone-remodeling theory applied to prosthetic-design analysis. , 1987, Journal of biomechanics.

[15]  R. Glowinski,et al.  Numerical Methods for Nonlinear Variational Problems , 1985 .

[16]  H. Rodrigues,et al.  A Model of Bone Adaptation Using a Global Optimisation Criterion Based on the Trajectorial Theory of Wolff. , 1999, Computer methods in biomechanics and biomedical engineering.

[17]  R T Whalen,et al.  Influence of physical activity on the regulation of bone density. , 1988, Journal of biomechanics.

[18]  S. Pal,et al.  Probabilistic computational modeling of total knee replacement wear , 2008 .

[19]  J. C. Simo,et al.  Numerical instabilities in bone remodeling simulations: the advantages of a node-based finite element approach. , 1995, Journal of biomechanics.

[20]  Stuart J Warden,et al.  Cellular accommodation and the response of bone to mechanical loading. , 2005, Journal of biomechanics.

[21]  M. Barboteu,et al.  A CLASS OF EVOLUTIONARY VARIATIONAL INEQUALITIES WITH APPLICATIONS IN VISCOELASTICITY , 2005 .

[22]  J. Langenderfer,et al.  Probabilistic Modeling of Knee Muscle Moment Arms: Effects of Methods, Origin–Insertion, and Kinematic Variability , 2007, Annals of Biomedical Engineering.

[23]  J. C. Simo,et al.  Adaptive bone remodeling incorporating simultaneous density and anisotropy considerations. , 1997, Journal of biomechanics.

[24]  Numerical analysis and simulations of a dynamic frictionless contact problem with damage , 2006 .

[25]  José Manuel García-Aznar,et al.  Numerical analysis of a strain-adaptive bone remodelling problem , 2010 .

[26]  José Manuel García-Aznar,et al.  Numerical analysis of a diffusive strain-adaptive bone remodelling theory , 2012 .

[27]  S. Mellon,et al.  Bone and its adaptation to mechanical loading: a review , 2012 .

[28]  Ellen Kuhl,et al.  Stress concentrations in fractured compact bone simulated with a special class of anisotropic gradient elasticity , 2010 .

[29]  Meir Shillor,et al.  Quasistatic evolution of damage in an elastic body: numerical analysis and computational experiments , 2007 .

[30]  Yves Rémond,et al.  A second gradient continuum model accounting for some effects of micro-structure on reconstructed bone remodelling , 2012 .