Potent preclinical sensitivity to imipridone-based combination therapies in oncohistone H3K27M-mutant diffuse intrinsic pontine glioma is associated with induction of the integrated stress response, TRAIL death receptor DR5, reduced ClpX and apoptosis.
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W. El-Deiry | Lanlan Zhou | N. Tapinos | R. Lulla | V. Prabhu | Yiqun Zhang | Robyn Borsuk | Aditi Sharma | Wen-i Chang