Dietary acrylamide and cancer of the large bowel, kidney, and bladder: Absence of an association in a population-based study in Sweden

Recently, disturbingly high levels of acrylamide were unexpectedly detected in widely consumed food items, notably French fries, potato crisps, and bread. Much international public concern arose since acrylamide has been classified as a probable carcinogen, although based chiefly on laboratory evidence; informative human data are largely lacking. We reanalysed a population-based Swedish case–control study encompassing cases with cancer of the large bowel (N=591), bladder (N=263) and kidney (N=133), and 538 healthy controls, assessing dietary acrylamide by linking extensive food frequency data with acrylamide levels in certain food items recorded by the Swedish National Food Administration. Unconditional logistic regression was used to estimate odds ratios, adjusting for potential confounders. We found consistently a lack of an excess risk, or any convincing trend, of cancer of the bowel, bladder, or kidney in high consumers of 14 different food items with a high (range 300–1200 μg kg−1) or moderate (range 30–299 μg kg−1) acrylamide content. Likewise, when we analysed quartiles of known dietary acrylamide intake, no association was found with cancer of the bladder or kidney. Unexpectedly, an inverse trend was found for large bowel cancer (P for trend 0.01) with a 40% reduced risk in the highest compared to lowest quartile. We found reassuring evidence that dietary exposure to acrylamide in amounts typically ingested by Swedish adults in certain foods has no measurable impact on risk of three major types of cancer. It should be noted, however, that relation of risk to the acrylamide content of all foods could not be studied.

[1]  Keith A. Johnson,et al.  Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. , 1986, Toxicology and applied pharmacology.

[2]  M. Törnqvist,et al.  Hemoglobin adducts and micronucleus frequencies in mouse and rat after acrylamide or N-methylolacrylamide treatment. , 2002, Mutation research.

[3]  G. Bond,et al.  Acrylamide cohort mortality study. , 1986, British journal of industrial medicine.

[4]  G. Steineck,et al.  Vitamin A supplements, fried foods, fat and urothelial cancer. A case‐referent study in Stockholm in 1985–87 , 1990, International journal of cancer.

[5]  F. Granath,et al.  Health effects of occupational exposure to acrylamide using hemoglobin adducts as biomarkers of internal dose. , 2001, Scandinavian journal of work, environment & health.

[6]  B. Wedzicha,et al.  Food chemistry: Acrylamide is formed in the Maillard reaction , 2002, Nature.

[7]  G. Swaen,et al.  Mortality patterns among workers exposed to acrylamide. , 1989, Journal of occupational medicine. : official publication of the Industrial Medical Association.

[8]  H. Kay Environmental Health Criteria , 1980 .

[9]  Gunnar Steineck,et al.  Dietary heterocyclic amines and cancer of the colon, rectum, bladder, and kidney: a population-based study , 1999, The Lancet.

[10]  M. Törnqvist,et al.  Acrylamide: a cooking carcinogen? , 2000, Chemical research in toxicology.

[11]  A O Youk,et al.  Mortality patterns among workers exposed to acrylamide: 1994 follow up. , 1999, Occupational and environmental medicine.

[12]  R J Bull,et al.  Carcinogenic effects of acrylamide in Sencar and A/J mice. , 1984, Cancer research.

[13]  D. Bleyl,et al.  IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs vol. 1 to 42. Supplement 7. 440 Seiten. International Agency for Research on Cancer, Lyon 1987. Preis: 65, – s.Fr , 1989 .

[14]  Assessing the human intake of heterocyclic amines: limited loss of information using reduced sets of questions. , 1999, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[15]  Imre Blank,et al.  Food chemistry: Acrylamide from Maillard reaction products , 2002, Nature.