Tumor hypoxia--a confounding or exploitable factor in interstitial brachytherapy? Effects of tissue trauma in an experimental rat tumor model.

[1]  P. Levendag,et al.  Equivalence of hyperfractionated and continuous brachytherapy in a rat tumor model and remarkable effectiveness when preceded by external irradiation. , 2001, International journal of radiation oncology, biology, physics.

[2]  S. Roberts,et al.  Changes in oxygenation during radiotherapy in carcinoma of the cervix. , 1999, International Journal of Radiation Oncology, Biology, Physics.

[3]  D. Hedley,et al.  A comparison in individual murine tumors of techniques for measuring oxygen levels. , 1999, International journal of radiation oncology, biology, physics.

[4]  S. Wenzel,et al.  Microvascular and tumor cell alterations during continuous hyperfractionated irradiation: an electron microscopic investigation on the rat R1H rhabdomyosarcoma. , 1999, International journal of radiation oncology, biology, physics.

[5]  J. Denekamp,et al.  Superfractionation as a potential hypoxic cell radiosensitizer: prediction of an optimum dose per fraction. , 1999, International journal of radiation oncology, biology, physics.

[6]  A M Peters,et al.  Fundamentals of tracer kinetics for radiologists. , 1998, The British journal of radiology.

[7]  G M Tozer,et al.  Modification of tumor blood flow: current status and future directions. , 1998, Seminars in radiation oncology.

[8]  D. Chaplin,et al.  Microenvironmental control of gene expression: implications for tumor angiogenesis, progression, and metastasis. , 1998, Seminars in radiation oncology.

[9]  J. Brown,et al.  Exploiting tumour hypoxia and overcoming mutant p53 with tirapazamine. , 1998, British Journal of Cancer.

[10]  A. Giaccia,et al.  The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. , 1998, Cancer research.

[11]  M. Horsman,et al.  Radiobiological hypoxia in the KHT sarcoma: predictions using the Eppendorf histograph. , 1998, International journal of radiation oncology, biology, physics.

[12]  A L Baert,et al.  Non-invasive tumour perfusion measurement by dynamic CT: preliminary results. , 1997, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[13]  H. Lyng,et al.  Oxygen tension in human tumours measured with polarographic needle electrodes and its relationship to vascular density, necrosis and hypoxia. , 1997, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[14]  G. Adams,et al.  The Klaas Breur Lecture. Radiation, hypoxia and genetic stimulation: implications for future therapies. , 1997, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[15]  B. Wouters,et al.  Cells at intermediate oxygen levels can be more important than the "hypoxic fraction" in determining tumor response to fractionated radiotherapy. , 1997, Radiation research.

[16]  K. Engin.  Biological rationale and clinical experience with hyperthermia. , 1996, Controlled clinical trials.

[17]  S. Dische,et al.  Clinical results of hypoxic cell radiosensitisation from hyperbaric oxygen to accelerated radiotherapy, carbogen and nicotinamide. , 1996, The British journal of cancer. Supplement.

[18]  P. Vaupel,et al.  Relevant parameters for describing the oxygenation status of solid tumors. , 1996, Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al].

[19]  R. Hill,et al.  Comparing techniques of measuring tumor hypoxia in different murine tumors: Eppendorf pO2 Histograph, [3H]misonidazole binding and paired survival assay. , 1996, Radiation research.

[20]  J. Overgaard,et al.  Modification of Hypoxia-Induced Radioresistance in Tumors by the Use of Oxygen and Sensitizers. , 1996, Seminars in radiation oncology.

[21]  J. Babb,et al.  Polarographic needle electrode measurements of oxygen in rat prostate carcinomas: accuracy and reproducibility. , 1995, International journal of radiation oncology, biology, physics.

[22]  E. Kochs,et al.  Tumor oxygenation in a transplanted rat rhabdomyosarcoma during fractionated irradiation. , 1995, International journal of radiation oncology, biology, physics.

[23]  J. Dunn,et al.  Changes of oxygen tension in experimental tumors after a single dose of X-ray irradiation. , 1995, Cancer research.

[24]  P. O'dwyer,et al.  Apoptosis in human adenocarcinoma HT29 cells induced by exposure to hypoxia. , 1995, Journal of the National Cancer Institute.

[25]  J. Overgaard,et al.  The importance of determining necrotic fraction when studying the effect of tumour volume on tissue oxygenation. , 1995, Acta oncologica.

[26]  N. Hattori,et al.  Tumor Blood Flow Measured Using Dynamic Computed Tomography , 1994, Investigative radiology.

[27]  A K Dixon,et al.  BW12C perturbs normal and tumour tissue oxygenation and blood flow in man. , 1994, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[28]  P. Olive.  Radiation-induced reoxygenation in the SCCVII murine tumour: evidence for a decrease in oxygen consumption and an increase in tumour perfusion. , 1994, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[29]  J. Brown,et al.  Reoxygenation and rehypoxiation in the SCCVII mouse tumor. , 1994, International journal of radiation oncology, biology, physics.

[30]  A G Visser,et al.  Optimization of interstitial volume implants. , 1994, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[31]  P. Levendag,et al.  Interstitial hyperthermia and interstitial radiotherapy of a rat rhabdomyosarcoma; effects of sequential treatment and consequences for clonogenic repopulation. , 1994, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[32]  G. Adams,et al.  Manipulation and exploitation of the tumour environment for therapeutic benefit. , 1994, International journal of radiation biology.

[33]  M. Lipton,et al.  Contrast Bolus Dynamic Computed Tomography for the Measurement of Solid Organ Perfusion , 1993, Investigative radiology.

[34]  J. Aldrich,et al.  Tumour blood flow: measurement and manipulation for therapeutic gain. , 1993, Cancer treatment reviews.

[35]  C. Grau,et al.  Relationship between radiobiological hypoxia and direct estimates of tumour oxygenation in a mouse tumour model. , 1993, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[36]  K. Hori,et al.  Circadian variation of tumor blood flow in rat subcutaneous tumors and its alteration by angiotensin II-induced hypertension. , 1992, Cancer research.

[37]  H. Beck-Bornholdt,et al.  Radiotherapy of the rhabdomyosarcoma R1H of the rat: recovery from radiation injury in tumour and skin. , 1992, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[38]  P. Levendag,et al.  Combined treatment with interstitial hyperthermia and interstitial radiotherapy in an animal tumor model. , 1991, International journal of radiation oncology, biology, physics.

[39]  K. Miles,et al.  Measurement of tissue perfusion by dynamic computed tomography. , 1991, The British journal of radiology.

[40]  Y. Shibamoto,et al.  Variations of the hypoxic fraction in the SCC VII tumors after single dose and during fractionated radiation therapy: assessment without anesthesia or physical restraint of mice. , 1991, International journal of radiation oncology, biology, physics.

[41]  T. Tenforde,et al.  Reoxygenation in a rat rhabdomyosarcoma tumor following X-irradiation. , 1991, International journal of radiation oncology, biology, physics.

[42]  J. Brown,et al.  Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation. , 1991, International journal of radiation oncology, biology, physics.

[43]  C. Grau,et al.  The influence of radiation dose on the magnitude and kinetics of reoxygenation in a C3H mammary carcinoma. , 1990, Radiation research.

[44]  J R Oleson,et al.  Blood perfusion measurements in human tumours: evaluation of laser Doppler methods. , 1990, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[45]  P. Okunieff,et al.  Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. , 1989, Cancer research.

[46]  H. Beck-Bornholdt,et al.  Radiotherapy of the rhabdomyosarcoma R1H of the rat: the influence of the number of fractions on tumor and skin response. , 1988, International journal of radiation oncology, biology, physics.

[47]  H. Beck-Bornholdt,et al.  Radiotherapy of the rhabdomyosarcoma R1H of the rat: kinetics of cellular inactivation by fractionated irradiation. , 1988, International journal of radiation oncology, biology, physics.

[48]  A M Peters,et al.  Noninvasive measurement of blood flow and extraction fraction. , 1987, Nuclear medicine communications.

[49]  I. Tannock,et al.  Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: potential implications for cell death in tumors. , 1986, Cancer research.

[50]  M. Dorie,et al.  Reoxygenation in the RIF-1 tumor. , 1984, International journal of radiation oncology, biology, physics.

[51]  S. Rockwell,et al.  Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data. , 1984, International journal of radiation oncology, biology, physics.

[52]  T. Tenforde,et al.  Assessment of tumour response in a rat rhabdomyosarcoma. , 1980, The British journal of cancer. Supplement.

[53]  R. Sutherland,et al.  Rate of death of hypoxic cells in multicell spheroids. , 1978, Radiation research.

[54]  J. J. Broerse,et al.  Experimental radiotherapy of a rat rhabdomyosarcoma with 15 meV neutrons and 300 kV x-rays. II. Effects of ractionated treatments, applied five times a week for several weeks. , 1970, European journal of cancer.

[55]  J. J. Broerse,et al.  Experimental radiotherapy of a rat rhabdomyosarcoma with 15 MeV neutrons and 300 kV x-rays. I. Effects of single exposures. , 1969, European journal of cancer.