Evaluation of the Potential of Elastography Technique for Detecting Different Tumors' Genera

Elastography is a promising imaging technique that produces images termed elastograms which map the strain experienced by tissue elements subjected to a quasi-static compression. In this paper, we represent analytic expressions modeling the strain field for an inclusion and its background when a circular homogeneous inclusion attached to a homogeneous infinite medium which is subjected to a remote uniform uniaxial compression, and base on this model, we discuss on the potential of elastography technique in differentiating various tumors' genera. We also represent some experimental results that imitate our results. Both the analytic relationships and the experimental results confirm that it is not reliable to make distinction between certain types of tumors through assessment of elastograms.

[1]  T. Hall.  AAPM/RSNA physics tutorial for residents: topics in US: beyond the basics: elasticity imaging with US. , 2003, Radiographics : a review publication of the Radiological Society of North America, Inc.

[2]  A. Gefen,et al.  Mechanics of the normal woman's breast. , 2007, Technology and health care : official journal of the European Society for Engineering and Medicine.

[3]  Michael F. Insana,et al.  Viscoelastic Imaging of Breast Tumor Microenvironment With Ultrasound , 2004, Journal of Mammary Gland Biology and Neoplasia.

[4]  Brett E. Bouma,et al.  Tissue Elasticity Estimation with Optical Coherence Elastography: Toward Mechanical Characterization of In Vivo Soft Tissue , 2005, Annals of Biomedical Engineering.

[5]  J Ophir,et al.  Fundamental limitations on the contrast-transfer efficiency in elastography: an analytic study. , 1996, Ultrasound in medicine & biology.

[6]  T A Krouskop,et al.  Nonlinear stress-strain relationships in tissue and their effect on the contrast-to-noise ratio in elastograms. , 2000, Ultrasound in medicine & biology.

[7]  D. Plewes,et al.  An inverse problem solution for measuring the elastic modulus of intact ex vivo breast tissue tumours , 2007, Physics in medicine and biology.

[8]  D. Plewes,et al.  Elastic moduli of normal and pathological human breast tissues: an inversion-technique-based investigation of 169 samples , 2007, Physics in medicine and biology.

[9]  Ruikang K. Wang,et al.  OCT-based elastography for large and small deformations. , 2006, Optics express.

[10]  J. Schmitt,et al.  OCT elastography: imaging microscopic deformation and strain of tissue. , 1998, Optics express.

[11]  Jonathan Ophir,et al.  Elastography: Imaging the elastic properties of soft tissues with ultrasound , 2002, Journal of Medical Ultrasonics.

[12]  A. Amano,et al.  Magnetic resonance elastography: in vivo measurements of elasticity for human tissue , 2004, International Conference on Informatics Research for Development of Knowledge Society Infrastructure, 2004. ICKS 2004..

[13]  Abbas Samani,et al.  Measuring the elastic modulus of ex vivo small tissue samples. , 2003, Physics in medicine and biology.

[14]  Vinay Kumar,et al.  A numerical study of finite element calculations for incompressible materials under applied boundary displacements , 2006 .

[15]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.