Nanoparticle superstructures made by polymerase chain reaction: collective interactions of nanoparticles and a new principle for chiral materials.

Polymerase chain reaction (PCR) was realized on the surface of gold nanoparticles (NPs) as a tool for self-organization at nanoscale and as a step toward programmable production of sufficient quantities of functional metallic superstructures. The assembly is controlled by varying the density of the primer on the surface of gold NPs and the number of PCR cycles generating a mixture of dimers, trimers, tetramers, etc., with gradually increasing complexity. This process leads to strong chirality of the assemblies arising from the three-dimensional positioning of NPs in space which had never been observed before. A circular dichroism band of the superstructures coincides with the plasmon oscillations of the multi-NP systems of Au colloids. This new collective optical property of NPs embracing the diversity of shapes and diameters in the starting dispersions opens unique opportunities for the development of negative index materials.

[1]  Nicholas A. Kotov,et al.  Free flow electrophoresis for the separation of CdTe nanoparticles , 2009 .

[2]  Y. Gun’ko,et al.  Chiral shells and achiral cores in CdS quantum dots. , 2008, Nano letters.

[3]  Thomas Bürgi,et al.  Chiral inversion of gold nanoparticles. , 2008, Journal of the American Chemical Society.

[4]  A. Alivisatos,et al.  Isolation of discrete nanoparticle-DNA conjugates for plasmonic applications. , 2008, Nano letters.

[5]  Peidong Yang,et al.  Shape Control of Colloidal Metal Nanocrystals , 2008 .

[6]  Rosemarie Portman.  Design by DNA , 2008 .

[7]  Sung Yong Park,et al.  DNA-programmable nanoparticle crystallization , 2008, Nature.

[8]  D. Lelie,et al.  DNA-guided crystallization of colloidal nanoparticles , 2008, Nature.

[9]  John M Kelly,et al.  Chiral highly luminescent CdS quantum dots. , 2007, Chemical communications.

[10]  Alexander Baev,et al.  A quantum chemical approach to the design of chiral negative index materials. , 2007, Optics express.

[11]  M. Wegener,et al.  Negative Refractive Index at Optical Wavelengths , 2007, Science.

[12]  Gil Markovich,et al.  Chirality of silver nanoparticles synthesized on DNA. , 2006, Journal of the American Chemical Society.

[13]  A. Alivisatos,et al.  Colloidal Synthesis of Hollow Cobalt Sulfide Nanocrystals , 2006 .

[14]  V. Yannopapas.  Negative index of refraction in artificial chiral materials , 2006 .

[15]  Yingfu Li,et al.  DNA polymerization on gold nanoparticles through rolling circle amplification: towards novel scaffolds for three-dimensional periodic nanoassemblies. , 2006, Angewandte Chemie.

[16]  T. Cui,et al.  Negative refractions in uniaxially anisotropic chiral media , 2006 .

[17]  Yu-Cheng Lin,et al.  Enhancing the efficiency of a PCR using gold nanoparticles , 2005, Nucleic acids research.

[18]  Lin‐Yue Lanry Yung,et al.  Nanoparticle-DNA conjugates bearing a specific number of short DNA strands by enzymatic manipulation of nanoparticle-bound DNA. , 2005, Langmuir : the ACS journal of surfaces and colloids.

[19]  H. Yao,et al.  Large optical activity of gold nanocluster enantiomers induced by a pair of optically active penicillamines. , 2005, Journal of the American Chemical Society.

[20]  Jun Hu,et al.  Nanoparticle PCR: nanogold-assisted PCR with enhanced specificity. , 2005, Angewandte Chemie.

[21]  Sailing He,et al.  Focusing by a slab of chiral medium. , 2005, Optics express.

[22]  Chengde Mao,et al.  DNA-encoded self-assembly of gold nanoparticles into one-dimensional arrays. , 2005, Angewandte Chemie.

[23]  Hebai Shen,et al.  Polymerase chain reaction of nanoparticle-bound primers , 2005 .

[24]  U. Chettiar,et al.  Negative index of refraction in optical metamaterials. , 2005, Optics letters.

[25]  T. Mackay.  Plane waves with negative phase velocity in isotropic chiral mediums , 2004, physics/0412131.

[26]  J. Pendry.  A Chiral Route to Negative Refraction , 2004, Science.

[27]  Itamar Willner,et al.  Integrated nanoparticle-biomolecule hybrid systems: synthesis, properties, and applications. , 2004, Angewandte Chemie.

[28]  H. Kojima,et al.  Interparticle spacing control in the superlattices of carboxylic acid-capped gold nanoparticles by hydrogen-bonding mediation. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[29]  Christine M. Micheel,et al.  Directed assembly of discrete gold nanoparticle groupings using branched DNA scaffolds , 2004 .

[30]  Yi Zhang,et al.  Positioning isolation and biochemical analysis of single DNA molecules based on nanomanipulation and single-molecule PCR. , 2004, Journal of the American Chemical Society.

[31]  A Paul Alivisatos,et al.  Discrete nanostructures of quantum dots/Au with DNA. , 2004, Journal of the American Chemical Society.

[32]  L. Liz‐Marzán,et al.  The Assembly of Coated Nanocrystals , 2003 .

[33]  Charles R Cantor,et al.  A high-throughput gene expression analysis technique using competitive PCR and matrix-assisted laser desorption ionization time-of-flight MS , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[34]  Christof M. Niemeyer,et al.  Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. , 2001, Angewandte Chemie.

[35]  Chad A Mirkin,et al.  Directed Assembly of Periodic Materials from Protein and Oligonucleotide-Modified Nanoparticle Building Blocks. , 2001, Angewandte Chemie.

[36]  C. P. Morris,et al.  Solid-phase amplification for detection of C282y and H63D hemochromatosis (HFE) gene mutations. , 2001, Clinical chemistry.

[37]  C. Mirkin,et al.  DNA-modified core-shell Ag/Au nanoparticles. , 2001, Journal of the American Chemical Society.

[38]  C. Mirkin,et al.  A fluorescence-based method for determining the surface coverage and hybridization efficiency of thiol-capped oligonucleotides bound to gold thin films and nanoparticles. , 2000, Analytical chemistry.

[39]  Robert L. Letsinger,et al.  The DNA-Mediated Formation of Supramolecular Mono- and Multilayered Nanoparticle Structures , 2000 .

[40]  George C Schatz,et al.  What controls the melting properties of DNA-linked gold nanoparticle assemblies? , 2000, Journal of the American Chemical Society.

[41]  R. Whetten,et al.  Giant Gold−Glutathione Cluster Compounds: Intense Optical Activity in Metal-Based Transitions , 2000 .

[42]  Chad A. Mirkin,et al.  Programmed Materials Synthesis with DNA. , 1999, Chemical reviews.

[43]  Christof M. Niemeyer,et al.  Progress in “engineering up” nanotechnology devices utilizing DNA as a construction material , 1999 .

[44]  M. Brust,et al.  Self-Assembled Gold Nanoparticle Thin Films with Nonmetallic Optical and Electronic Properties , 1998 .

[45]  T. Mallouk,et al.  Layer-by-Layer Assembly of Thin Film Zener Diodes from Conducting Polymers and CdSe Nanoparticles , 1998 .

[46]  P. Schultz,et al.  Organization of 'nanocrystal molecules' using DNA , 1996, Nature.

[47]  J. Storhoff,et al.  A DNA-based method for rationally assembling nanoparticles into macroscopic materials , 1996, Nature.

[48]  K. Mullis,et al.  Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. , 1988, Science.

[49]  V. Shalaev.  Optical negative-index metamaterials , 2007 .

[50]  Taihua Li,et al.  Circular dichroism study of chiral biomolecules conjugated nanoparticles , 2004 .