The Acute Pharmacokinetics and Pharmacodynamics of Amrinone in Pediatric Patients

A mrinone is a bipyridine derivative that is used in the management of myocardial dysfunction in critically ill pediatric patients. A feature of amrinone when observed in adult studies is a relationship between improvement in cardiac index and increasing plasma concentrations of amrinone.5 Therefore, rapid attainment of a therapeutic plasma concentration is important. There is increasing evidence in both adult6 and pediatric patients,1 however, that the current recommended loading dose of amrinone7 may not result in therapeutic concentrations. This study determined the acute pharmacokinetics and pharmacodynamics of amrinone in critically ill pediatric patients and determined whether a larger loading dose would result in therapeutic amrinone concentrations and resultant hemodynamic effects.

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