Runx3 is required for oncogenic Myc upregulation in p53-deficient osteosarcoma
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Tomoko Ito | J. Toguchida | T. Komori | I. Taniuchi | M. Umeda | Kosei Ito | T. Ueno | Yuki Date | K. Omori | S. Kajikawa | Shohei Otani
[1] D. Tenen,et al. Super-enhancers for RUNX3 are required for cell proliferation in EBV-infected B cell lines. , 2021, Gene.
[2] H. Komori,et al. Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts , 2020, PLoS genetics.
[3] Kosei Ito,et al. Oncogenic RUNX3: A Link between p53 Deficiency and MYC Dysregulation , 2020, Molecules and cells.
[4] J. Bushweller. Targeting transcription factors in cancer — from undruggable to reality , 2019, Nature Reviews Cancer.
[5] D. Herranz,et al. The MYC Enhancer-ome: Long-Range Transcriptional Regulation of MYC in Cancer. , 2018, Trends in cancer.
[6] J. Dekker,et al. CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia , 2018, Cell.
[7] Howard Y. Chang,et al. Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element , 2018, Cell.
[8] Jia Gu,et al. fastp: an ultra-fast all-in-one FASTQ preprocessor , 2018, bioRxiv.
[9] A. Tanay,et al. Multiscale 3D Genome Rewiring during Mouse Neural Development , 2017, Cell.
[10] Y. Kaneda,et al. Genetic regulation of the RUNX transcription factor family has antitumor effects , 2017, The Journal of clinical investigation.
[11] Dmitriy Sonkin,et al. TP53 Variations in Human Cancers: New Lessons from the IARC TP53 Database and Genomics Data , 2016, Human mutation.
[12] Mazhar Adli,et al. Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers , 2016, EBioMedicine.
[13] Fidel Ramírez,et al. deepTools2: a next generation web server for deep-sequencing data analysis , 2016, Nucleic Acids Res..
[14] Yunlong He,et al. A RUNX2-Mediated Epigenetic Regulation of the Survival of p53 Defective Cancer Cells , 2016, PLoS genetics.
[15] C. Bonaïti‐pellié,et al. Revisiting Li-Fraumeni Syndrome From TP53 Mutation Carriers. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[16] L. Wood,et al. RUNX3 Controls a Metastatic Switch in Pancreatic Ductal Adenocarcinoma , 2015, Cell.
[17] Howard H. Yang,et al. p53 Loss Increases the Osteogenic Differentiation of Bone Marrow Stromal Cells , 2015, Stem cells.
[18] S. Takeda,et al. Loss of Osteoblast Runx3 Produces Severe Congenital Osteopenia , 2015, Molecular and Cellular Biology.
[19] Yoshiaki Ito,et al. The RUNX family: developmental regulators in cancer , 2015, Nature Reviews Cancer.
[20] Howard Y. Chang,et al. ATAC‐seq: A Method for Assaying Chromatin Accessibility Genome‐Wide , 2015, Current protocols in molecular biology.
[21] A. V. van Wijnen,et al. RUNX3 Facilitates Growth of Ewing Sarcoma Cells , 2014, Journal of cellular physiology.
[22] David M. Thomas,et al. Translational biology of osteosarcoma , 2014, Nature Reviews Cancer.
[23] L. Zender,et al. Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles , 2014, Nature.
[24] D. Felsher,et al. MYC activation is a hallmark of cancer initiation and maintenance. , 2014, Cold Spring Harbor perspectives in medicine.
[25] Li Ding,et al. Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma. , 2014, Cell reports.
[26] Karen H. Vousden,et al. Mutant p53 in Cancer: New Functions and Therapeutic Opportunities , 2014, Cancer cell.
[27] S. Gabriel,et al. Discovery and saturation analysis of cancer genes across 21 tumor types , 2014, Nature.
[28] Luke A. Gilbert,et al. CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes , 2013, Cell.
[29] Yoshiaki Ito,et al. RUNX family: Regulation and diversification of roles through interacting proteins , 2013, International journal of cancer.
[30] R. Young,et al. Transcriptional Regulation and Its Misregulation in Disease , 2013, Cell.
[31] W. Reinhold,et al. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1–CBFβ interaction , 2012, Proceedings of the National Academy of Sciences.
[32] Steven L Salzberg,et al. Fast gapped-read alignment with Bowtie 2 , 2012, Nature Methods.
[33] David S. Lapointe,et al. Genomic Promoter Occupancy of Runt-related Transcription Factor RUNX2 in Osteosarcoma Cells Identifies Genes Involved in Cell Adhesion and Motility* , 2011, The Journal of Biological Chemistry.
[34] G. Stein,et al. The Role of RUNX2 in Osteosarcoma Oncogenesis , 2010, Sarcoma.
[35] C. Glass,et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. , 2010, Molecular cell.
[36] A. Nakagawara,et al. RUNX3 Modulates DNA Damage-mediated Phosphorylation of Tumor Suppressor p53 at Ser-15 and Acts as a Co-activator for p53* , 2010, The Journal of Biological Chemistry.
[37] O. Myklebost,et al. Molecular characterization of commonly used cell lines for bone tumor research: A trans‐European EuroBoNet effort , 2010, Genes, chromosomes & cancer.
[38] M. Bouxsein,et al. Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage , 2008, Proceedings of the National Academy of Sciences.
[39] F. Alt,et al. Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. , 2008, Genes & development.
[40] D. Littman,et al. Repression of interleukin-4 in T helper type 1 cells by Runx/Cbfβ binding to the Il4 silencer , 2007, The Journal of experimental medicine.
[41] M. Salto‐Tellez,et al. RUNX3, A Novel Tumor Suppressor, Is Frequently Inactivated in Gastric Cancer by Protein Mislocalization , 2005 .
[42] D. Levanon,et al. Structure and regulated expression of mammalian RUNX genes , 2004, Oncogene.
[43] D. Littman,et al. Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development , 2002, Cell.
[44] Kenneth Chu,et al. Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC , 2002, Science.
[45] S. Itohara,et al. Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer , 2002, Cell.
[46] A. Berns,et al. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer , 2001, Nature Genetics.
[47] P. Picci,et al. C-myc and c-fos in Human Osteosarcoma: Prognostic Value of mRNA and Protein Expression , 1998, Oncology.
[48] Makoto Sato,et al. Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts , 1997, Cell.
[49] E. Wagner,et al. Osteoblasts are target cells for transformation in c-fos transgenic mice , 1993, The Journal of cell biology.
[50] S. Holden,et al. A significant proportion of patients with osteosarcoma may belong to Li-Fraumeni cancer families. , 1992, The Journal of bone and joint surgery. British volume.
[51] D. Lane,et al. Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others , 2018, Nature Reviews Clinical Oncology.
[52] N. Speck,et al. RUNX Proteins in Development and Cancer , 2017 .
[53] Yoshiaki Ito,et al. Roles of RUNX in Solid Tumors. , 2017, Advances in experimental medicine and biology.
[54] I. Wierstra,et al. The c-myc promoter: still MysterY and challenge. , 2008, Advances in cancer research.
[55] M. Salto‐Tellez,et al. RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization. , 2005, Cancer research.
[56] F. Alt,et al. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. , 2001, Immunity.