论文信息 - Non-invasive glucose monitoring using open electromagnetic waveguides

Non-invasive glucose monitoring using open electromagnetic waveguides

This paper presents a novel approach towards non-invasive glucose measurement. The introduced concept is based on an electromagnetic (EM) wave transmission along blood vessels. Theoretical investigation of a TEM wave propagation through a aqueous glucose solution is shown. The concept was evaluated by a simplified demonstrator which consists of a dielectric covered TEM-Waveguide. A 3D field simulation of the structure has been performed with a glucose dependent Debye relaxation model. The EM waveguide was fabricated and measured with various glucose concentrations. A phase difference of 12 deg for a 500mg/dl variation in glucose concentration was measured at 20GHz.

[1] B. R. Jean,et al. A microwave frequency sensor for non-invasive blood-glucose measurement , 2008, 2008 IEEE Sensors Applications Symposium.

[2] David Whiting,et al. IDF Diabetes Atlas : sixth edition , 2013 .

[3] Joseph Wang,et al. Glucose Biosensors : 40 Years of Advances and Challenges , 2001 .

[4] R. Weigel,et al. A microwave sensing system for aqueous concentration measurements based on a microwave reflectometer , 2012, 2012 IEEE/MTT-S International Microwave Symposium Digest.

[5] Y. Nikawa,et al. Non-invasive measurement of blood-sugar level by reflection of millimeter-waves , 2006, 2006 Asia-Pacific Microwave Conference.

[6] S. S. Stuchly,et al. Analysis of a Microstrip Covered with a Lossy Dielectric , 1980 .

[7] Dietmar Kissinger,et al. A novel approach to non-invasive blood glucose measurement based on RF transmission , 2011, 2011 IEEE International Symposium on Medical Measurements and Applications.