The Accuracy of Indonesian New Local Skin Prick Test (SPT) Allergen Extracts as Diagnostic Tool of IgE-mediated Atopic Dermatitis

Background: Skin Prick Test (SPT) is good diagnostic tool of allergic disease such as Atopic Dermatitis (AD). Imported allergen extracts are expensive and not always available in Indonesia. New local SPT allergen extracts are potential as substitute. Objective: To compare SPT results of new local and imported allergen extracts (house dust mite, chicken, egg white, cow’s milk, and shrimp), and specific IgE in AD patients. Methods: This was clinical trial of 45 non lesional AD patients. The SPT of imported allergen extracts was performed in the first week, followed by the new local and specific IgE examination in the next one week. Result: Sensitivity (Sn) of new local compared with imported allergen extracts in this study was between 15.38%-84.61%, the highest point was house dust mite extract. Specificity (Sp) was ranged from 81.48%-93.75%, the highest rank was shrimp extract. Compared with IgE results, the Sn of new local and imported house dust mite extracts was good (85.7%; 92.9%). The Sp was good for egg white and cow’s milk new local extracts (86.4%; 84.4%). Conclusion: New local allergen extracts should be considered as a substitute of the imported diagnostic tool.

[1]  N. Visitsunthorn,et al.  Food sensitization and food allergy in allergic Thai patients from a tertiary care center in Thailand. , 2019, Asian Pacific journal of allergy and immunology.

[2]  J. Baeyens,et al.  Questioning the “SPIN and SNOUT” rule in clinical testing , 2019, Archives of Physiotherapy.

[3]  N. Wagner,et al.  Sensitivity and specificity of standardised allergen extracts in skin prick test for diagnoses of IgE-mediated respiratory allergies , 2019, Clinical and Translational Allergy.

[4]  E. Pope,et al.  Diagnosis and Management of Atopic Dermatitis: A Review , 2018, Advances in skin & wound care.

[5]  D. Margolis,et al.  Epidemiology of atopic dermatitis in adults: Results from an international survey , 2018, Allergy.

[6]  J. Vaněčková,et al.  Sensitivity and specificity of specific IgE, skin prick test and atopy patch test in examination of food allergy , 2017 .

[7]  N. Visitsunthorn,et al.  Comparison between specific IgE levels and skin prick test results of local and imported American cockroach, dog, cat, dust mites and mold allergen extracts. , 2016, Asian Pacific journal of allergy and immunology.

[8]  M. Ospina,et al.  Retrospective analysis on the agreement between skin prick test and serum food specific IgE antibody results in adults with suspected food allergy , 2016, Allergy, Asthma & Clinical Immunology.

[9]  Paediatric Pulmonologist.  A guide to performing skin-prick testing in practice: tips and tricks of the trade , 2013 .

[10]  M. McHugh.  Interrater reliability: the kappa statistic , 2012, Biochemia medica.

[11]  I. Rushdan,et al.  Comparison of serum specific IgE with skin prick test in the diagnosis of allergy in Malaysia. , 2011, The Medical journal of Malaysia.

[12]  L. Strömberg.  Diagnostic accuracy of the atopy patch test and the skin‐prick test for the diagnosis of food allergy in young children with atopic eczema/dermatitis syndrome , 2002, Acta paediatrica.

[13]  Hugh A Sampson,et al.  Improving in-vitro tests for the diagnosis of food hypersensitivity , 2002, Current opinion in allergy and clinical immunology.